Category: 6413-10-1

Studies on catalytic synthesis of fructone with modified fly ash was written by Liu, Xianxiang;Yin, Dulin;Yang, Yongjun;Zuo, Chuanpeng;Wang, Jihui. And the article was included in Riyong Huaxuepin Kexue in 2009.Category: dioxole The following contents are mentioned in the article:

The synthesis of fructone from Et acetoacetate and ethylene glycol using fly ash modified by ammonium persulfate as solid acid catalyst was investigated. Various reaction parameters such as reaction time, ratio of Et acetoacetate to ethylene glycol, catalyst amount and water-carrying reagent amount were studied. The optimum reaction conditions were as follows: the molar ratio of Et acetoacetate to ethylene glycol 1:1.8, the quantity of catalyst 1.5 weight% by weight of Et acetoacetate, amount of cyclohexane 15 mL, and the reaction time 3 h. Under this optimum condition, the yield of fructone reaches 95.9%. The exptl. results showed that fly ash modified by ammonium persulfate was an excellent catalyst for synthesis of fructone. Compared with other acid catalysts, the sulfonated activated carbon has higher activity, less used quantity and reusability. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Category: dioxole).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Catalytic synthesis of 2-methyl-2-ethyl acetoacetate-1,3-dioxolane with iodine was written by Yang, Shuijin;Tong, Wenlong. And the article was included in Jingxi Shiyou Huagong Jinzhan in 2008.Reference of 6413-10-1 The following contents are mentioned in the article:

In this paper, 2-methyl-2-Et acetoacetate-1, 3-dioxolane was synthesized from Et acetoacetate and ethylene glycol using I₂ as catalyst. The effects of molar ratio of Et acetoacetate to ethylene, the catalyst dosage and reaction time on the yield of 2-methyl-2-Et acetoacetate-1,3-dioxolane were investigated. Comparison of catalytic activity of different catalysts was made. Exptl. result showed that yield of 2-methyl-2-Et acetoacetate-1,3-dioxolane could reach 73.2 % under the conditions as follows: molar ratio of Et acetoacetate to ethylene 1:1.8, the dosage of catalyst 0.3 % based on feed stocks, cyclohexane as carrying-water reagent, and the reaction time 1.0 h. The catalyst had a fairly high catalytic activity for the ketalization reaction, and had the characteristics in short reaction time, less catalyst dosage and high yield. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Reference of 6413-10-1).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Reference of 6413-10-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Enantioselective microbial hydrolysis of dissymmetrical cyclic carbonates with disubstitution was written by Nogawa, Masaki;Sugawara, Satomi;Iizuka, Rie;Shimojo, Megumi;Ohta, Hiromichi;Hatanaka, Minoru;Matsumoto, Kazutsugu. And the article was included in Tetrahedron in 2006.Product Details of 6413-10-1 The following contents are mentioned in the article:

Enantioselective microbial hydrolysis of C₁ and C₂ dissym. cyclic carbonates with disubstitution (Me and another groups) has been developed. Pseudomonas diminuta (FU0090), a bacterium, efficiently catalyzes the hydrolysis of five-membered cyclic carbonates. While the trans-substrates are hydrolyzed with low enantioselectivities and/or reactivities, the microbe hydrolyzes the cis-substrates with very high enantioselectivities to afford the corresponding almost optically pure anti-(2R,3S)-diols. On the other hand, six-membered trans-cyclic carbonates are enantioselectively hydrolyzed to afford the corresponding optically active syn-(2R,4R)-diols, although the hydrolysis of the cis-substrates gives racemic compounds In all cases, the enzyme prefers the (R)-enantiomer for the carbon atom bearing a Me group. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Product Details of 6413-10-1).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Product Details of 6413-10-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Catalytic synthesis of fructone by a new solid sulfonic acid sulfonated activated carbon was written by Xu, Qiong;Yin, Dulin;Zhong, Wenzhou;Peng, Chuanzhi;Wang, Jihui. And the article was included in Xiangliao Xiangjing Huazhuangpin in 2007.Reference of 6413-10-1 The following contents are mentioned in the article:

Synthesis of fructone from Et acetoacetate and ethylene glycol using sulfonated activated carbon as solid acid catalyst was investigated. Various reaction parameters such as ratio of Et acetoacetate to ethylene glycol, catalyst amount, reaction time and water-carrying reagent amount were studied. The optimum reaction conditions were: the molar ratio of Et acetoacetate to ethylene glycol was 1:1.8, the quantity of catalyst was equal to 2% Et acetaoacetate, amount of cyclohexane was 20mL, and the reaction time was 3 h. The yield of fructone reached 93.1%, and its selectivity was nearly 100% under the optimum condition. The sulfonated activated carbon was an excellent catalyst for synthesis of fructone. Compared with other acid catalysts, the sulfonated activated carbon has higher activity, less usage and no pollution. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Reference of 6413-10-1).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Reference of 6413-10-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Study on catalytic synthesis of fructone was written by Deng, Bin;Zhang, Aihua;Xu, Anwu. And the article was included in Shangqiu Shifan Xueyuan Xuebao in 2009.Reference of 6413-10-1 The following contents are mentioned in the article:

Microwave irradiation was used in the catalytic synthesis of fructone from Et acetoacetate and ethanol using nanometer Y₂O₃ as a catalyst. The influence of microwave irradiation power, microwave irradiation time, mole ratio of ethanol to Et acetoacetate, and the dosage of the catalyst on the reaction was investigated. The optimum reaction conditions determined through orthogonal design were as follows: microwave irradiation power was 400 W, microwave irradiation time 9 min, the mole ratio of ethanol to Et acetoacetate was 1.2 : 1 and the dosage of the catalyst was 2.0 g. Under the optimum reaction conditions the yield of fructone was above 95 %. In summary, the microwave technique promotes the synthesis of fructone with high yield and convenient operation and has extensive utilization. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Reference of 6413-10-1).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Reference of 6413-10-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Ammonium salts catalyzed acetalization reactions in green ethereal solvents was written by Azzena, Ugo;Carraro, Massimo;Corrias, Martina;Crisafulli, Rosella;De Luca, Lidia;Gaspa, Silvia;Nuvoli, Luca;Pintus, Salvatore;Pisano, Luisa;Polese, Riccardo;Sanna, Michela;Satta, Giuseppe;Senes, Nina;Urtis, Luigi;Garroni, Sebastiano. And the article was included in Catalysts in 2020.Name: Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate The following contents are mentioned in the article:

Cyclopentyl Me ether and 2-methyltetrahydrofuran, low impact ethereal solvents forming a pos. azeotrope with water, were successfully employed as solvents in the synthesis of a variety of acetals carried out under Dean-Stark conditions in the presence of heterogeneous acidic catalysts. Under these conditions, ammonium salts, either as such or supported on SiO₂, performed better or equally well than widely employed homogeneous and heterogeneous acidic catalysts such as p-toluenesulfonic acid, Amberlyst 15, or Montmorillonite K10. Several examples highlight the advantage of tuning the relative acidities of ammonium salts by appropriately selecting the counterion. Within one of these examples, our protocol clearly outweighs the classic p-toluenesulfonic acid/toluene protocol in terms of chemoselectivity. Silica-supported catalysts were characterized by SEM, TEM, and FTIR spectroscopies, as well as by N₂ physisorption. Such a characterization reveals an even distribution of ammonium salts on silica, thus confirming the formation of expected catalytic supports. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Name: Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Name: Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

A Comparative Human Health Risk Assessment of p-Dichlorobenzene-Based Toilet Rimblock Products Versus Fragrance/Surfactant-Based Alternatives was written by Aronson, Dallas B.;Bosch, Stephen;Gray, D. Anthony;Howard, Philip H.;Guiney, Patrick D.. And the article was included in Journal of Toxicology and Environmental Health in 2007.Synthetic Route of C8H14O4 The following contents are mentioned in the article:

Consumer human health risks from using 1 of 2 types of toilet rimblock products, a p-dichlorobenzene-based rimblock or 2 newer fragrance/surfactant-based alternatives, were assessed. Rimblock products, designed for consumer use worldwide, function by releasing volatile compounds into indoor air with subsequent exposure presumed to be mainly via inhalation. Using the THERdbASE exposure model and exptl. determined emission data, indoor air concentrations and daily intake values were determined for both types of rimblock products. Modeled exposure concentrations from a representative p-dichlorobenzene rimblock product were 1 order of magnitude higher than those from the alternative rimblock products due to its nearly pure composition and high sublimation rate. Lifetime exposure to p-dichlorobenzene or the subset of fragrance components with available reference dose values was not expected to lead to non-cancer-based adverse health effects based on exposure concentrations estimated using the THERdbASE model. A similar comparison of cancer-based effects was not possible since insufficient data were available for the fragrance components. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Synthetic Route of C8H14O4).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Synthetic Route of C8H14O4

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis of fructone and its derivatives by using acidic ionic liquid as catalyst was written by Yi, Feng-ping;Zhang, Xuan;Pan, Xian-hua;Chen, Shi-hong. And the article was included in Huaxue Shiji in 2011.Quality Control of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate The following contents are mentioned in the article:

The acid functional ionic liquid 1-(4-sulfobutyl)-3-methylpyrazinium tetrafluoroborate (abbreviated as [4-sulfbmpyrazine][BF₄]), was prepared Fructone and its derivatives I(R¹ = H, Me, R² = MeO, EtO) and II(R = EtO, MeO) were prepared by the reaction of Et acetoacetate and diol in the presence of [4-sulfbmpyrazine][BF₄] as acidic catalyst. And the proper technol. conditions were identified as follows by orthogonal experiments The proper reaction conditions of fructone is a ratio of mol n(Et acetoacetate):n(ethylene glycol) = 0.10:0.15, the reaction time of 6 h, the amount of catalyst of 0.5 g and the amount of cyclohexane as carrying-water reagent of 40 mL. The yield could reach 95.4%. Six kinds of derivatives of fructone are synthesized using acidic functional ionic liquid as catalyst. The catalyst had a fairly high catalytic activity and high yield. The acidic functional ionic liquid could be recovered and reused for at least five times without the loss of efficiency. It provided a new and green way for the synthesis of Fructone and its derivatives This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Quality Control of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Quality Control of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Condensation on the silica-supported cerium (IV) sulfate solid acid catalyst was written by Ren, Liguo;Zhang, Xiaoli;Gao, Wenyi. And the article was included in Xitu in 2012.Reference of 6413-10-1 The following contents are mentioned in the article:

Silica-supported cerium (IV) sulfate [Ce(SO₄)₂/SiO₂] solid acid catalyst was prepared by sol-gel and impregnation methods. The catalytic activities for condensation of Et acetoacetate with 1,3-butandiol were evaluated with the same condition. The effects of the calcination temperature of the catalyst, mass fraction of cerium (IV) sulfate, molar ratio of Et acetoacetate to 1,3-butandiol, mass fraction of Ce(SO₄)₂/SiO₂ and reaction time were discussed in detail. It showed that Ce(SO₄)₂/SiO₂ solid acid was more active than cerium (IV) sulfate tetrahydrate. The yield of fructone was more than 95.5% under the condensation conditions of calcination temperature of catalyst 500 degree, mass fraction of cerium (IV) sulfate 15.0%, molar ratio of Et acetoacetate to 1,3-butandiol 1:1.2, mass fraction of Ce(SO₄)₂/SiO₂ in Et acetoacetate 7.5% and reaction time 120 min. The experiments also revealed that the Ce(SO₄)₂/SiO₂ catalyst had good repetitious and reproducible stability. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Reference of 6413-10-1).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Reference of 6413-10-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Design, synthesis and biological evaluation of multifunctional tacrine-curcumin hybrids as new cholinesterase inhibitors with metal ions-chelating and neuroprotective property was written by Liu, Zhikun;Fang, Lei;Zhang, Huan;Gou, Shaohua;Chen, Li. And the article was included in Bioorganic & Medicinal Chemistry in 2017.Recommanded Product: Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate The following contents are mentioned in the article:

Total sixteen tacrine-curcumin hybrid compounds were designed and synthesized for the purpose of searching for multifunctional anti-Alzheimer agents. In vitro studies showed that these hybrid compounds showed good cholinesterase inhibitory activity. Particularly, the potency of K_3-2 is even beyond tacrine. Some of the compounds exhibited different selectivity on acetylcholinesterase or butyrylcholinesterase due to the structural difference. Thus, the structure and activity relationship is summarized and further discussed based on mol. modeling studies. The ORAC and MTT assays indicated that the hybrid compounds possessed pronounced antioxidant activity and could effectively protect PC12 cells from the H₂O₂/Aβ42-induced toxicity. Moreover, the hybrid compounds also showed pos. metal ions-chelating ability in vitro, suggesting a potential to halt ion-induced Aβ aggregation. All the obtained results demonstrated that the tacrine-curcumin hybrid compounds, in particular compound K_3-2, can be considered as potential therapeutic agents for Alzheimer’s disease. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Recommanded Product: Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Recommanded Product: Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem