Category: 6413-10-1

Synthesis of fructone over dealuminated USY supported heteropoly acid and its salt catalysts was written by Zhang, Fumin;Yuan, Chaoshu;Wang, Jun;Kong, Yan;Zhu, Haiyang;Wang, Chunyan. And the article was included in Journal of Molecular Catalysis A: Chemical in 2006.Computed Properties of C8H14O4 The following contents are mentioned in the article:

12-Phosphotungstic acid (PW) and cesium salt of PW supported on dealuminated ultra-stable Y zeolite (DUSY) with various loadings were prepared by impregnation method, and their physicochem. properties were characterized by X-ray powder diffraction (XRD), N₂ adsorption, solid state ³¹P and ²⁹Si MAS NMR, Hammett indicator and SEM techniques. Their catalytic performances were evaluated in the liquid-phase acetalization of Et acetoacetate with ethylene glycol to fructone. The catalytic stability was tested using water treatment, in which the concentration of heteropoly compound was measured by UV-visual spectrophotometer. A high catalytic activity was found over the supported heteropoly compound catalysts. However, for the supported PW catalysts, a severe leaching of heteropoly anions into water was observed, leading to their poor reusability. By contrast, the Cs salt of PW catalyst supported on DUSY exhibited very high catalytic activity with high water-tolerance and reusability. The conversion of Et acetoacetate of 98.7% with the selectivity of fructone above 97% could be obtained over the DUSY supported sample containing 30% of Cs_2.5H_0.5PW₁₂O₄₀ by weight at the optimal reaction conditions, and a considerable catalytic activity still could be achieved after five times of reaction cycle. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Computed Properties of C8H14O4).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Computed Properties of C8H14O4

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Bronsted acidic cellulose-PO₃H: An efficient catalyst for the chemoselective synthesis of fructones and trans-esterification via condensation of acetoacetic esters with alcohols and diols was written by Naikwadi, Dhanaji R.;Singh, Amravati S.;Biradar, Ankush V.. And the article was included in Molecular Catalysis in 2021.Name: Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate The following contents are mentioned in the article:

Cellulose is the most abundant organic source and has expedient a great deal of interest as renewable and emerged as sustainable feedstock. The functionalization of cellulose as designed catalytic system intriguing furnished to the production of fine chems. Herein, we synthesized an environmental friendly solid acid catalyst by functionalizing cellulose with phosphoric acid (PO₃H). The successful functionalization of cellulose with PO₃H was confirmed by ³¹P NMR, ICP-OES, FE-SEM, and XPS anal. ICP-OES revealed the presence of phosphorus content of ~1.0 weight % on the catalyst’s surface while elemental mapping by FESEM and XPS shows a uniform distribution of phosphorus over the material. The synthesized solid acid catalyst was utilized for condensation of diols with acetoacetic esters in solvent-free conditions to synthesize fine chems. The present approach not only circumvented the one-step protection and other products but more fascinatingly provided trans-esterification of acetoacetic esters with diols and n-alcs. The catalyst was successfully used for chemoselective protection on Et acetoacetate with 1,2 diols to essential fructone mol. with ~100% conversion and 99% selectivity. The results suggested that the catalyst has the advantage over com. solid acid heterogeneous and homogeneous catalysts. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Name: Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Name: Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Identification of agonists for a group of human odorant receptors was written by Gonzalez-Kristeller, Daniela C.;do Nascimento, Joao B. P.;Galante, Pedro A. F.;Malnic, Bettina. And the article was included in Frontiers in Pharmacology in 2015.Recommanded Product: Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate The following contents are mentioned in the article:

Olfaction plays a critical role in several aspects of the human life. Odorants are detected by hundreds of odorant receptors (ORs) which belong to the superfamily of G protein-coupled receptors. These receptors are expressed in the olfactory sensory neurons of the nose. The information provided by the activation of different combinations of Ors in the nose is transmitted to the brain, leading to odorant perception and emotional and behavioral responses. There are ∼400 itact human ORs, and to date only a small percentage of these receptors (∼10%) have known agonists. The determination of the specificity of the human Ors will contribute to a better understanding of how odorants are discriminated by the olfactory system. In this work, we aimed to identify human specific ORs, i.e., Ors that are present in humans but absent from other species, and their corresponding agonists. To do this, we first selected 22 OR gene sequences from the human genome with no counter parts in the mouse, rat or dog genomes. Then we use a heterologous expression system to screen a subset of these human Ors against a panel of odorants of biol. relevance, including foodborne aroma volatiles. We found that different types of odorants are able to activate some of these previously uncharacterized human ORs. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Recommanded Product: Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Recommanded Product: Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Potential hazard of volatile organic compounds contained in household spray products was written by Rahman, Mahmudur Md;Kim, Ki-Hyun. And the article was included in Atmospheric Environment in 2014.Application of 6413-10-1 The following contents are mentioned in the article:

To assess the exposure levels of hazardous volatile pollutants released from common household spray products, a total of 10 spray products consisting of six body spray and four air spray products have been investigated. The body spray products included insect repellents (two different products), medicated patch, deodorant, hair spray, and humectant, whereas the air spray products included two different insecticides (mosquito and/or cockroach), antibacterial spray, and air freshener. The main objective of this study was to measure concentrations of 15 model volatile organic compounds (VOCs) using GC/MS coupled with a thermal desorber. In addition, up to 34 ‘compounds lacking authentic standards or surrogates (CLASS)’ were also quantified based on the effective carbon number (ECN) theory. According to our anal., the most common indoor pollutants like benzene, toluene, styrene, Me Et ketone, and Bu acetate have been detected frequently in the majority of spray products with the concentration range of 5.3-125 mg L^-1. If one assumes that the amount of spray products released into air reaches the 0.3 mL level for a given space size of 5 m³, the risk factor is expected to exceed the carcinogenic risk level set for benzene (10^-5) by the U. S. EPA. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Application of 6413-10-1).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Application of 6413-10-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Analysis of volatile compounds in meat of cultivated puffer fish (Takifugu obscurus) by simultaneous distillation and extraction (SDE) combined with GC-MS was written by Wu, Rong;Tao, Ning-ping;Liu, Yuan;Wang, Xi-chang. And the article was included in Shipin Yu Fajiao Gongye in 2012.Safety of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate The following contents are mentioned in the article:

The volatile compounds in meat of cultivated puffer fish (Takifugu obscurus) were extracted by simultaneous distillation and extraction (SDE) with dichloromethane and di-Et ether, resp. GC-MS was used for qual. anal. of volatile components. The quantities of volatiles were determined with 2, 4, 6-trimethylpyridine as the internal standard Principal component anal. (PCA) was used in analyzing the differences and similarities. The results indicated that the volatile compounds obtained using di-Et ether extraction were mainly contributed from tetradecanal (4963.71 ng/g), octadecanal (1171.51 ng/g), (Z)-13-Octadecenal (2007.21 ng/g), Et acetate (1148.44 ng/g), n-hexadecanoic acid (4639.90 ng/g). A total of 57 compounds were identified. The major volatile compounds with dichloromethane extraction were hexadecanal (2381.77 ng/g), 2, 3-butanedione (1267.40 ng/g), n-hexadecanoic acid (545.08 ng/g). A total of 78 compounds were acquired. Dichloromethane extraction was better on qual. aspects, while di-Et ether extracts has advantages in the quant. aspects. A total of 96 compounds with two solvents were identified, including aldehydes (29), ketones (11), alcs. (16), N-containing or S-containing compounds and aromatics (22), esters (7), acids (3), alkanes (8). This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Safety of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Safety of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Catalytic synthesis of acetals and ketals with iodine was written by Yang, Shuijin;Tong, Wenlong. And the article was included in Xiangliao Xiangjing Huazhuangpin in 2006.Synthetic Route of C8H14O4 The following contents are mentioned in the article:

Catalytic activities of Iodine in synthesizing 2-methyl-2-ethoxycarbonylmethyl-1,3-dioxolane, 2,4-dimethyl-2-ethoxycarbonylmethyl-1,3-dioxolane, cyclohexanone ethylene ketal, cyclohexanone 1,2-propanediol ketal, butanone ethylene ketal, butanone 1,2-propanediol ketal, 2-phenyl-1,3-dioxolane, 4-methyl-2-phenyl-1,3-dioxolane, 2-propyl-1,3-dioxolane, 4-methyl-2-propyl-1,3-dioxolane were reported. It was demonstrated that Iodine was an excellent catalyst. Various factors concerned in these reactions were investigated. The optimum conditions were found, that was, the molar ratio of aldehyde/ketone to glycol was 1/1.3, the mass ratio of the catalyst used to the reactant s was 0.4%, and the reaction time was 40-60 min. Under these conditions, the yield of 2-methyl-2-ethoxycarbonylmethyl-1,3-dioxolane was 63.8%, and 2,4-dimethyl-2-ethoxycarbonylmethyl-1,3-dioxolane was 70.7%, the yield of cyclohexanone ethylene ketal was 85.9%, and cyclohexanone 1,2-propanediol ketal was 88.8%, the yield of butanone ethylene ketal was 45.2%, and butanone 1,2-propanediol ketal was 86.9%, the yield of 2-phenyl-1,3-dioxolane was 80.3%, and 4-methyl-2-phenyl-1,3-dioxolane was 86.3%, the yield of 2-propyl-1,3-dioxolane was 83.6%, and 4-methyl-2-propyl-1,3-dioxolane was 91.2%. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Synthetic Route of C8H14O4).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Synthetic Route of C8H14O4

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Amidation Reactions from the Direct Coupling of Metal Carboxylate Salts with Amines was written by Goodreid, Jordan D.;Duspara, Petar A.;Bosch, Caroline;Batey, Robert A.. And the article was included in Journal of Organic Chemistry in 2014.Related Products of 6413-10-1 The following contents are mentioned in the article:

A general method for the synthesis of amides involving the direct coupling of alkali metal carboxylate salts with amines is described. Amidation of a wide variety of carboxylate salts with either free amines or their ammonium hydrochloride salts can be achieved using HBTU as a coupling agent in combination with Huenig’s base. The reaction is highly efficient and is generally complete in as little as 1-2 h, giving the products in good to excellent yields. The protocol is valuable for the coupling of carboxylates for which the corresponding carboxylic acids or acyl chlorides are unstable, less conveniently manipulated/isolated, or are not com. available. For example, the coupling of amines and α-amino acids with lithium 5-bromo-1H-pyrrole-2-carboxylate, whose corresponding acid that is prone to decarboxylation, allowed for the synthesis of 5-bromo-1H-pyrrole-2-carboxamides, which are analogs of the pyrrole-2-aminoimidazole marine alkaloids. The protocol can be combined with other reactions in a sequenced fashion, as exemplified by the synthesis of acetylenic amides, in a one-pot procedure, via the coupling of a lithium carboxylate salt formed initially by the addition of carbon dioxide to a lithiated terminal alkyne. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Related Products of 6413-10-1).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Related Products of 6413-10-1

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Total synthesis and anti-inflammatory evaluation of violacin A and its analogues was written by Liu, Qingyin;Mu, Yu;An, Qi;Xun, Jiali;Ma, Jian;Wu, Wenxi;Xu, Minjuan;Xu, Jun;Han, Li;Huang, Xueshi. And the article was included in Bioorganic Chemistry in 2020.Application In Synthesis of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate The following contents are mentioned in the article:

A concise total synthesis of an exceedingly potent anti-inflammatory agent violacin A (I) as well as the preparation of thirty analogs of this lead from com. available orcinol are described. Highlights of our synthetic efforts involve Friedel-Crafts acylation, the regioselective etherification and esterification of phenolic hydroxyl groups, and Baker-Venkataraman rearrangement to form basic skeleton of violacin A. The deprotection reaction with Pd-catalytic was involved to avoid the elimination of the hemiacetal hydroxyl at C2. In addition, all synthetic compounds were screened for anti-inflammatory activity against nitric oxide (NO) production using lipopolysaccharide (LPS)-induced Raw264.7 cells. A range of violacin A derivatives II – V [R = Me, (un)substituted benzyl] exhibited stronger anti-inflammatory effect than that of violacin A. Notably, halogeno-benzyloxy substituent at C-7 were favorable for anti-inflammatory activities of violacin A derivatives Addnl., Western blot results indicated halogeno-benzyloxy derivatives inhibited pro-inflammatory cytokines releases correlated with the suppression of NF-κB signaling pathway. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Application In Synthesis of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Application In Synthesis of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Catalytic behavior of SBA-15 supported heteropoly compounds in synthesis of fructone was written by Zhang, Fu-min;Yuan, Chao-shu;Wang, Jun. And the article was included in Gaoxiao Huaxue Gongcheng Xuebao in 2006.Formula: C8H14O4 The following contents are mentioned in the article:

Catalysts of 12-tungstophosphoric acid (PW), cesium salt of PW and potassium salt of PW supported on mesoporous silica SBA-15 with different loadings were prepared by impregnation, resp. Their catalytic behaviors were investigated via the acetalization of Et acetoacetate with ethylene glycol to synthesize fructone. The phys. and chem. properties of the catalysts prepared were characterized by N₂ adsorption, Hammett indicator and FT-IR. The catalytic stability of the catalysts was evaluated by water treatment test, in which the concentration of the heteropoly compound leaking into the water was measured by UV-visual spectrophotometer. It is found that the catalysts have no activity in the synthesis of fructone when the loading of PW on SBA-15 is lower than 30% and the loading of Cs salt or K salt of PW on SBA-15 is lower than 20%. During repeatedly using, the deactivation of the catalysts prepared is closely associated with the leakage of active heteropoly species into the polar solvent. Since in the polar reaction system, the cesium salts of PW are water-tolerant, it causes the catalyst of supported cesium salts of PW on SBA-15 has higher catalytic stability. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Formula: C8H14O4).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Formula: C8H14O4

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Preparation and testing of ceasium Bronsted ion-exchanged Al-SBA-15 supported heteropoly acid as heterogeneous catalyst in the fructone fragrancy synthesis was written by Tran, Quang Vinh;Truong, Thi Hanh;Hung, Tran Quang;Doan, Huan V.;Pham, Xuan Nui;Le, Nam Thi Hoai;Bach, Long Giang;Nguyen, Van Tuyen. And the article was included in Journal of Porous Materials in 2020.Safety of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate The following contents are mentioned in the article:

Here we report a new ceasium Bronsted ion-exchanged Al-SBA-15 (Cs/AS15) supported heteropoly acid (HPA) H₃PW₁₂O₄₀ (HPA-Cs/AS15) material which can be prepared and used as heterogeneous catalyst for the fructone fragrancy synthesis. It was demonstrated that Cs⁺ was more effective than NH₄⁺ as counter cation of ion-exchanged AS15 support for preparing HPA/AS15 catalyst with higher acidity and HPA leaching stability. HPA-Cs/AS15 material showed high acidity with the maximum NH₃ desorption peak appeared at 759.6°C in the NH₃-TPD spectrum, stronger than pure HPA (635.7°C) and the ammonium Bronsted ion-exchanged Al-SBA-15 supported HPA (HPA-NH₄/AS15) (559.1°C) materials. The HPA leaching stability test showed that the HPA content of HPA-Cs/AS15 catalyst reduced only by 2.55% after five washing times, much less than that of HPA-NH₄/AS15 catalyst (49.22%). The higher acidity helped improve the HPA-Cs/AS15 catalyst performance in the fructone fragrancy synthesis. The Et acetoacetate conversion over this catalyst was 94.82%, better than those over HPA-NH₄/AS15 (93.49%) and pure HPA (89.52%) catalysts, although HPA-Cs/AS15 catalyst had lower HPA content (23.16 wt%) than HPA-NH₄/AS15 (24.28 wt%). In addition, it was shown that the reaction conditions such as Et acetoacetate:ethanediol reactant molar ratio of 1:1.5, ethanediol used as the diol reactant, and toluene used as the solvent, the fructone fragrancy synthesis reaction over HPA-Cs/AS15 catalyst reached the highest Et acetoacetate conversion (95.58%). The toluene’s boiling temperature of 110.6°C can promote the dispersion and contact abilities of the reactants with HPA mols. presented inside the pores of HPA-Cs/AS15 catalyst. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Safety of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate).

Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Safety of Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem