Category: 607-91-0

Anticariogenic Activity of Three Essential Oils from Brazilian Piperaceae was written by Carvalho, Eni S.;Ayres, Vanessa F. S.;Oliveira, Midia R.;Correa, Geone M.;Takeara, Renata;Guimaraes, Anderson C.;Santiago, Mariana B.;Oliveira, Thais A. S.;Martins, Carlos H. G.;Crotti, Antonio E. M.;Silva, Eliane O.. And the article was included in Pharmaceuticals in 2022.Related Products of 607-91-0 This article mentions the following:

The current trend toward using natural food additives, cosmetics, and medicines has motivated industries to substitute synthetic compounds for natural products. Essential oils (EOs) from medicinal plants are a well-known source of chem. compounds that display several interesting biol. activities, including antimicrobial action. In this study, we investigated the antibacterial activity of EOs extracted from three Piperaceae species collected in the Brazilian Amazon region against a representative panel of cariogenic bacteria. The min. inhibitory concentration (MIC) of the essential oils extracted from Peperomia pellucida (PP-EO), Piper marginatum (PM-EO), and Piper callosum (PC-EO) was determined against Streptococcus mutans, S. mitis, S. sanguinis, S. salivarius, S. sobrinus, Enterococcus faecalis, and Lactobacillus casei by using the microplate microdilution method. PM-EO, PC-EO, and PP-EO displayed antibacterial activity against all the tested cariogenic bacteria. PM-EO displayed the best inhibitory activity, with MIC values ranging from 50 to 500μg/mL. The lowest MIC values were obtained for PM-EO against S. mitis (MIC = 75μg/mL), Lactobacillus casei (MIC = 50μg/mL), and S. mutans (MIC = 50μg/mL). Gas chromatog. mass spectrometry (GC-MS) anal. allowed the chem. composition of all the EOs to be identified. The main constituents of PM-EO, PC-EO, and PP-EO were 3,4-(methylenedioxy)propiophenone, α-pinene, and dillapiole, resp. Finally, the compounds that were exclusively detected in PM-EO are highlighted. Our results suggest that PM-EO may be used in products for treating dental caries and periodontal diseases. In the experiment, the researchers used many compounds, for example, 6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0Related Products of 607-91-0).

6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Related Products of 607-91-0

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Comprehensive Comparison of Two Color Varieties of Perillae Folium by GC-MS-Based Metabolomic Approach was written by Chen, Jiabao;Zhang, Dan;Wang, Qian;Yang, Aitong;Zheng, Yuguang;Wang, Lei. And the article was included in Molecules in 2022.Application of 607-91-0 This article mentions the following:

Perillae Folium (PF), the leaf of Perilla frutescens (L.) Britt, is extensively used as culinary vegetable in many countries. It can be divided into two major varietal forms based on leaf color variation, including purple PF (Perilla frutescens var. arguta) and green PF (P. frutescens var. frutescens). The aroma of purple and green PF is discrepant. To figure out the divergence of chem. composition in purple and green PF, gas chromatog.-tandem mass spectrometry (GC-MS) was applied to analyze compounds in purple and green PF. A total of 54 compounds were identified and relatively quantified. Multivariate statistical methods, including principal component anal. (PCA), orthogonal partial least-squares discrimination anal. (OPLS-DA) and clustering anal. (CA), were used to screen the chem. markers for discrimination of purple and green PF. Seven compounds that accumulated discrepantly in green and purple PF were characterized as chem. markers for the discrimination of the purple and green PF. Among these 7 marker compounds, limonene, shisool and perillaldehyde that from the same branch of the terpenoid biosynthetic pathway were with relatively higher contents in purple PF, while perilla ketone, isoegomaketone, tocopheryl and squalene on other branch pathways were higher in green PF. The results of the present study are expected to provide theor. support for the development and utilization of PF resources. In the experiment, the researchers used many compounds, for example, 6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0Application of 607-91-0).

6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Application of 607-91-0

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Cloning of the cytochrome P450 enzyme from Perilla frutescens involved in nothoapiole biosynthesis was written by Baba, Mariko;Ito, Michiho. And the article was included in Journal of Natural Medicines in 2021.Recommanded Product: 6-Allyl-4-methoxybenzo[d][1,3]dioxole This article mentions the following:

Phenylpropanoid volatile components are found in various plants and are useful in medicines, health foods, and fragrances. While the pharmacol. actions and toxicities of these compounds have been investigated, there are few reports of the cloning of genes that encode biosynthetic enzymes involved in substituent formation at diverse positions and numbers Previously, using the expressed sequence tag (EST) libraries of pure perilla strains that have been maintained for over 30 years for their oil type, we characterized the P 450 enzyme that produces an intermediate for dillapiole by adding a hydroxy group to myristicin. In this study, we selected a P 450 enzyme involved in nothoapiole biosynthesis from the EST library. Heterologous expression of this enzyme in yeast showed that it is a hydroxylase that synthesizes an intermediate to produce nothoapiole from apiole and dillapiole. The enzyme has high amino acid sequence similarity with a previously cloned enzyme and is categorized into the CYP71D subfamily. Furthermore, we investigated the presence or absence of essential oil components and intermediates believed to be involved in nothoapiole biosynthesis by component anal. of perilla essential oil using GC-MS to help elucidate the biosynthetic pathway of nothoapiole. Only a small number of plant species contain nothoapiole as their principal component and thus few studies have reported the biosynthetic genes involved or the drug efficacy and toxicity of nothoapiole. The present study will aid in understanding the biosynthesis of phenylpropanoid volatile compounds, thereby contributing to further research on potentially useful compounds such as nothoapiole. In the experiment, the researchers used many compounds, for example, 6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0Recommanded Product: 6-Allyl-4-methoxybenzo[d][1,3]dioxole).

6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Recommanded Product: 6-Allyl-4-methoxybenzo[d][1,3]dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Selective fluorescence labeling of myristicin using Mizoroki-Heck coupling reaction. Application to nutmeg powder, oil, and human plasma samples was written by Fukuda, Takayuki;Iwata, Hikaru;Kishikawa, Naoya;El-Maghrabey, Mahmoud H.;Ohyama, Kaname;Kawakami, Shigeru;Wada, Mitsuhiro;Kuroda, Naotaka. And the article was included in Journal of Chromatography A in 2022.Related Products of 607-91-0 This article mentions the following:

Myristicin [5-allyl-1-methoxy-2,3-(methylenedioxy)benzene] is the major constituent of the seasoning nutmeg oil and powder. Sometimes myristicin is abused via its ingestion at high doses to cause hallucination. In these high doses, myristicin could cause severe adverse health effects, including convulsion, delirium, and palpitation. Hence there is a strong need for a sensitive method for its anal., such as fluorescence determination Myristicin has a very weak fluorescence and also lacks derivatizable groups like the carboxylic, hydroxyl, or amino group in its structure, which makes its fluorescence derivatization challenging. In this research, we developed a fluorescence labeling method for myristicin based on the Mizoroki-Heck coupling reaction of its terminal alkene with a fluorescent aryl iodide derivative, 4-(4,5-diphenyl-1H-imidazol-2-yl)iodobenzene (DIB-I). Then, we developed an HPLC fluorescence detection method for the determination of myristicin utilizing this labeling reaction. The developed method showed a good linear response for myristicin (r = 0.995) in the range of 0.01-10 μmol/L with excellent sensitivity down to the detection limit of 2.9 nmol/L (9.6 fmol/injection). Finally, the developed method could be successfully applied to determine myristicin content in nutmeg powder, oil samples, and human plasma with simple extraction methods and good recoveries ranging from 89.3 to 106%. In the experiment, the researchers used many compounds, for example, 6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0Related Products of 607-91-0).

6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Related Products of 607-91-0

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Application of growth promoting hormones alters the composition and antioxidant potential of dill essential oil under salt stress was written by Ghassemi-Golezani, Kazem;Nikpour-Rashidabad, Neda;Samea-Andabjadid, Samira. And the article was included in Scientific Reports in 2022.SDS of cas: 607-91-0 This article mentions the following:

The performance of dill plant may be affected by adverse environments such as salinity. Thus, this research was designed to evaluate changes in chem. composition and antioxidant activity of seed essential oil of dill (Anethum graveolens L.) in response to salinity (0, 5, 10 and 15 dS/m) and 1 mM of each hormonal treatments (gibberellic acid, salicylic acid, and cytokinin). Salicylic acid (SA) reduced Na+ content of roots and leaves by 15.4%, 30.9% and 12.4%, 24.3%, but enhanced K+ content by 29.8%, 51.6% and 76.6%, 73.4% under moderate and severe salinities, resp. Essential oil yield was enhanced with progressing seed filling, despite decreasing essential oil percentage. Percentage of essential oil was increased under low and moderate salinities. Hormonal treatments, particularly SA enhanced seed mass and essential oil percentage, leading to enhanced essential oil yield. The amounts of most constituents were enhanced under moderate salinity. Foliar spray of SA and CK (cytokinin) increased almost all essential oil components, except dill ether and dill apiole, while the GA3 (gibberellic acid) treatment reduced most of the constituents. The α-fenchol was only induced by salt stress. The β-pinene, 1-terpineol, cryptone, oxypeucedanin hydrate, α-thujene and P-α-dimethylstyrene were also specifically synthesized in SA treated plants under salinity. The highest TPC (total phenolic content) and antioxidant activity were recorded for essential oil of SA treated plants at mass maturity under moderate salinity. In general, the SA spray was the most effective treatment for improving essential oil quantity and quality of dill plants. In the experiment, the researchers used many compounds, for example, 6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0SDS of cas: 607-91-0).

6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.SDS of cas: 607-91-0

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Seasonal variation of the composition of essential oils from Piper cernuum Vell and Piper rivinoides Kunth, ADMET study, DFT calculations, molecular docking and dynamics studies of major components as potent inhibitors of the heterodimer methyltransferase complex NSP16-NSP10 SARS COV-2 protein was written by Alves Borges Leal, Antonio Linkoln;Fonseca Bezerra, Camila;Ferreira e Silva, Andressa Kelly;Everson da Silva, Luiz;Bezerra, Lucas Lima;Almeida-Neto, Francisco Wagner;Marinho, Emanuelle Machado;Celedonio Fernandes, Carla Freire;Nunes da Rocha, Matheus;Marinho, Marcia Machado;Coutinho, Henrique D. M.;Barreto, Humberto Medeiros;Rafaela Freitas Dotto, Ana;Amaral, Wanderlei do;Santos, Helcio Silva dos;Lima-Neto, Pedro de;Marinho, Emmanuel Silva. And the article was included in Journal of Biomolecular Structure and Dynamics.Formula: C11H12O3 This article mentions the following:

Coronavirus disease (COVID-19) has the virus that causes the SARS-CoV-2 severe acute respiratory syndrome, which has reached a pandemic proportion, with thousands of deaths worldwide already registered. In this context, the present study aimed to evaluate the influence of seasonality on the yield and chem. composition of the essential oils of Piper cernuum and Piper rivinoides as well as to evaluate the anti-SARS-CoV-2 potential of the major components of each oil by mol. docking and quantum chem. calculation (D. Functional Theory method), being possible indicate that the winter and autumn periods, the seasons of the year where it is possible to obtain the highest percentage of Piper cernuum and Piper rivinoides oils, resp. Regarding the anti-SARS-Cov-2 potential, the present work showed that the dihydroagarofuran present in Piper cernuum, presented a strong interaction with amino acid residues from Mpro, presenting a potential similar to Remdesivir, a drug for clin. use. Regarding methyltransferase, dihydroagarofuran (Piper cernuum) and myristicin (Piper rivinoids) showed better affinity, with important interactions at the active site of the inhibitor Sinefugin, suggesting a potential inhibitory effect of the heterodimer methyltransferase complex NSP16-NSP10 SARS Cov-2. Mol. docking and mol. dynamics studies represent an initial step, being indicative for future in vitro studies of dihydroagarofuran and myristicin, as possible pharmacol. tools for COVID-19. In the experiment, the researchers used many compounds, for example, 6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0Formula: C11H12O3).

6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Formula: C11H12O3

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Analysis of volatile components in Asarum heterotropoides by HS-SPME/GC-MS was written by Wang, Feng;Li, Nan;Li, Xue;Zhong, Lingyan;Huang, Zetian;Hu, Ping. And the article was included in Riyong Huaxue Gongye in 2021.Quality Control of 6-Allyl-4-methoxybenzo[d][1,3]dioxole This article mentions the following:

Asarum is a kind of commonly used traditional Chinese medicine, and volatile oil is the main material basis for its efficacy. In traditional studies, the volatile oil is extracted by steam distillation and analyzed by GC-MS. Although the extraction method is easy to operate and has low cost, it is time-consuming, large sample consumption, high extraction temperature and easy thermal decomposition of active components. Moreover, xylene is often added in this method to promote the stratification of volatile oil, which brings great interference to the subsequent GC-MS anal. and component identification of volatile oil. Therefore, Solid Phase microextraction (SPME) technol. that integrates extraction, purification, enrichment, and sampling functions was used to analyze the volatile oil of Asarum for the first time. The HS-SPME/GC-MS method was established to analyze Asarum heterotropoides, and the volatile components were identified by the NIST spectral library search and retention index. A total of 68 components were identified from the volatile oil of Asarum heterotropoides from 6 origins. The relative content of Me eugenol was the highest among the volatile components with peak area percentages ranging from 17.20% to 33.80%. The application of HS-SPME/GC-MS method to the study of the volatile components in Asarum heterotropoides can reflect the overall differences, and the method is simple and rapid, providing new ideas for the quality evaluation of Asarum heterotropoides. In the experiment, the researchers used many compounds, for example, 6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0Quality Control of 6-Allyl-4-methoxybenzo[d][1,3]dioxole).

6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Quality Control of 6-Allyl-4-methoxybenzo[d][1,3]dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Anticariogenic Activity of Three Essential Oils from Brazilian Piperaceae was written by Carvalho, Eni S.;Ayres, Vanessa F. S.;Oliveira, Midia R.;Correa, Geone M.;Takeara, Renata;Guimaraes, Anderson C.;Santiago, Mariana B.;Oliveira, Thais A. S.;Martins, Carlos H. G.;Crotti, Antonio E. M.;Silva, Eliane O.. And the article was included in Pharmaceuticals in 2022.Related Products of 607-91-0 This article mentions the following:

The current trend toward using natural food additives, cosmetics, and medicines has motivated industries to substitute synthetic compounds for natural products. Essential oils (EOs) from medicinal plants are a well-known source of chem. compounds that display several interesting biol. activities, including antimicrobial action. In this study, we investigated the antibacterial activity of EOs extracted from three Piperaceae species collected in the Brazilian Amazon region against a representative panel of cariogenic bacteria. The min. inhibitory concentration (MIC) of the essential oils extracted from Peperomia pellucida (PP-EO), Piper marginatum (PM-EO), and Piper callosum (PC-EO) was determined against Streptococcus mutans, S. mitis, S. sanguinis, S. salivarius, S. sobrinus, Enterococcus faecalis, and Lactobacillus casei by using the microplate microdilution method. PM-EO, PC-EO, and PP-EO displayed antibacterial activity against all the tested cariogenic bacteria. PM-EO displayed the best inhibitory activity, with MIC values ranging from 50 to 500μg/mL. The lowest MIC values were obtained for PM-EO against S. mitis (MIC = 75μg/mL), Lactobacillus casei (MIC = 50μg/mL), and S. mutans (MIC = 50μg/mL). Gas chromatog. mass spectrometry (GC-MS) anal. allowed the chem. composition of all the EOs to be identified. The main constituents of PM-EO, PC-EO, and PP-EO were 3,4-(methylenedioxy)propiophenone, α-pinene, and dillapiole, resp. Finally, the compounds that were exclusively detected in PM-EO are highlighted. Our results suggest that PM-EO may be used in products for treating dental caries and periodontal diseases. In the experiment, the researchers used many compounds, for example, 6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0Related Products of 607-91-0).

6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Related Products of 607-91-0

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Authenticating wild Piper species (peppers) originating from islands in the Indian Ocean on the basis of morphological, genetic and chemical characteristics was written by Weil, Mathieu;Leong PockTsy, Jean Michel;Razafimandimby, Harizoly. And the article was included in Phytochemistry (Elsevier) in 2021.Application of 607-91-0 This article mentions the following:

As demand for pepper is rising to unprecedented levels, gaps in our knowledge are underlined by our inability to reliably distinguish the different species, in particular in the south-western Indian Ocean; this hampers the possibility of developing their economic potential and protect them efficiently. The aim of this study was to characterize two species of Piper (piperaceae) from Madagascar and one from Reunion Island via a multidisciplinary approach combining botany, genetics and chem. and to propose authentication keys. Morphometric analyses were carried out on 22 quant. and qual. descriptors of the leaf and infructescence. Genetic analyses were conducted through DNA extraction, amplification by PCR and sequencing. Chem. analyses used spectrophotometric and chromatog. methods to determine concentrations in piperine and essential oil and describe the chemotypes of the sampled individuals. Our tri-disciplinary approach showed that the three peppers studied are very different from Piper nigrum L. Reunionese Piper borbonense and M3 Malagasy pepper clearly differ from the M1 Malagasy morphotype. Piper borbonense and M3 pepper appear to be closely related; a distinction could possibly be made at the variety (var.) or form (fa.) level on the basis of morphometry and according to piperine content for chem. In the experiment, the researchers used many compounds, for example, 6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0Application of 607-91-0).

6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Application of 607-91-0

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Selective fluorescence labeling of myristicin using Mizoroki-Heck coupling reaction. Application to nutmeg powder, oil, and human plasma samples was written by Fukuda, Takayuki;Iwata, Hikaru;Kishikawa, Naoya;El-Maghrabey, Mahmoud H.;Ohyama, Kaname;Kawakami, Shigeru;Wada, Mitsuhiro;Kuroda, Naotaka. And the article was included in Journal of Chromatography A in 2022.Related Products of 607-91-0 This article mentions the following:

Myristicin [5-allyl-1-methoxy-2,3-(methylenedioxy)benzene] is the major constituent of the seasoning nutmeg oil and powder. Sometimes myristicin is abused via its ingestion at high doses to cause hallucination. In these high doses, myristicin could cause severe adverse health effects, including convulsion, delirium, and palpitation. Hence there is a strong need for a sensitive method for its anal., such as fluorescence determination Myristicin has a very weak fluorescence and also lacks derivatizable groups like the carboxylic, hydroxyl, or amino group in its structure, which makes its fluorescence derivatization challenging. In this research, we developed a fluorescence labeling method for myristicin based on the Mizoroki-Heck coupling reaction of its terminal alkene with a fluorescent aryl iodide derivative, 4-(4,5-diphenyl-1H-imidazol-2-yl)iodobenzene (DIB-I). Then, we developed an HPLC fluorescence detection method for the determination of myristicin utilizing this labeling reaction. The developed method showed a good linear response for myristicin (r = 0.995) in the range of 0.01-10 μmol/L with excellent sensitivity down to the detection limit of 2.9 nmol/L (9.6 fmol/injection). Finally, the developed method could be successfully applied to determine myristicin content in nutmeg powder, oil samples, and human plasma with simple extraction methods and good recoveries ranging from 89.3 to 106%. In the experiment, the researchers used many compounds, for example, 6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0Related Products of 607-91-0).

6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Related Products of 607-91-0

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem