Category: 57-50-1

Chemical Research Letters, April 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. Formula: C12H22O1157-50-1, Name is Sucrose, SMILES is O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@H]1O[C@@]2(CO)[C@H]([C@@H]([C@@H](CO)O2)O)O, belongs to dioxole compound. In a article, author is Wu, CD, introduce new discover of the category.

Structure-activity relationships of N-2-aryl-3-(isoxazolylsulfamoyl)-2-thiophenecarboxamides as selective endothelin receptor-A antagonists

We report here that N-2-aryl-3-(isoxazolylsulfamoyl)-2-thiophenecarboxamides are potent and selective small molecule ETA receptor antagonists. The aryl group was subjected to extensive structural modification. With monosubstitution, the para position was most useful in increasing potency, with methyl being preferred. With disubstitution, 2,4-disubstitution further enhanced activity with methyl or cyano groups being preferred at the 2-position. In this series, a benzo-[d][1,3]dioxole group is equivalent to a 4-methyl group in in vitro activity and afforded the compounds with both in vivo activity and moderate half-lives.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 57-50-1. Formula: C12H22O11.

Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

New research progress on 57-50-1 in 2021. Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. In an article, author is Ocola, Esther J., once mentioned the application of 57-50-1, Application In Synthesis of Sucrose, Name is Sucrose, molecular formula is C12H22O11, molecular weight is 342.2965, MDL number is MFCD00006626, category is dioxole. Now introduce a scientific discovery about this category.

Anomeric Effect in Five-Membered Ring Molecules: Comparison of Theoretical Computations and Experimental Spectroscopic Results

As demonstrated in previous spectroscopic studies of 1,3-dioxole [J. Am. Chem. Soc., 1993, 115, 12132-12136] and 1,3-benzodioxole [J. Am. Chem. Soc., 1999, 121, 5056-5062], analysis of the ring-puckering potential energy function (PEF) of a pseudo-four-membered ring molecule can provide insight into understanding the magnitude of the anomeric effect. In the present study, high-level CCSD/cc-pVTZ and somewhat lower-level MP2/cc-pVTZ ab initio computations have been utilized to calculate the PEFs for 1,3-dioxole and 1,3-benzodioxole and 10 related molecules containing sulfur and selenium atoms and possessing the anomeric effect. The potential energy parameters derived for the PEFs directly provide a comparison of the relative magnitudes of the anomeric effect for molecules possessing OCO, OCS, OCSe, SCS, SCSe, and SeCSe linkages. The torsional potential energies produced by the anomeric effect for these linkages were estimated to range from 5.97 to 1.91 kcal/mol. The ab initio calculations also yielded the structural parameters, barriers to planarity, and ring-puckering angles for each of the 12 molecules studied. Based on the refined structural parameters for 1,3-dioxole and 1,3-benzodioxole, improved PEFs for these molecules were also calculated. The calculations also support the conclusion that the relatively low barrier to planarity of 1,3-benzodioxole results from competitive interactions between its benzene ring and the oxygen atom p orbitals.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 57-50-1, in my other articles. Application In Synthesis of Sucrose.

Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

New Advances in Chemical Research, April 2021. Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. Computed Properties of C12H22O1157-50-1, Name is Sucrose, SMILES is O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@H]1O[C@@]2(CO)[C@H]([C@@H]([C@@H](CO)O2)O)O, belongs to dioxole compound. In a article, author is Bondar, VI, introduce new discover of the category.

Sorption of gases and vapors in an amorphous glassy perfluorodioxole copolymer

Gas and vapor sorption properties of a random copolymer of 87 mol % 2,2-bis(trifluoromethyl)-4,5-difluoro-1,3-dioxole and 13% tetrafluoroethylene (AF2400) are reported. Using both pressure decay and inverse gas chromatography (IGC) methods, a wide range of solutes was studied: He, Nz, Oz, CO2, C-1-C-13 n-alkanes, CF4, C2F6, C6F6, and C6F5CF3. These solutes have critical temperatures ranging from 5 to 677 K. AF2400 has very large solubility coefficients, S, relative to other glassy and rubbery polymers. Only poly(1-trimethylsilyl-1-propyne), the most permeable polymer known, exhibits higher solubility coefficients. The large solubility coefficients in AF2400 are mainly due to high Henry’s law solubility coefficients. Fluorocarbon solutes exhibit higher solubility than their hydrocarbon analogues. A novel linear correlation between the logarithm of S and T-c(2), where T-c is the solute critical temperature, was observed. On the basis of IGC results, the microcavity size in this perfluoropolymer is larger than in conventional hydrocarbon-based glassy polymers.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 57-50-1. The above is the message from the blog manager. Computed Properties of C12H22O11.

Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

New Advances in Chemical Research, April 2021. Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media. 57-50-1, Name is Sucrose, SMILES is O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@H]1O[C@@]2(CO)[C@H]([C@@H]([C@@H](CO)O2)O)O, belongs to dioxole compound. In a document, author is Li, Yan, introduce the new discover, SDS of cas: 57-50-1.

9-{[4-(Dimethylamino)benzyl]amino}-5-(3,4,5-trimethoxyphenyl)-5,5a,8a,9-tetrahydrofuro[3 ‘,4 ‘:6,7]naphtho[2,3-d][1,3]dioxol-6(8H)-one

In the title compound, C31H34N2O7, the fused tetrahydrofuran and six-membered rings each display an envelope conformation. The dihedral angles between the benzene ring of the benzo[d][1,3]dioxole and the other two benzene rings are 89.68 (3) and 63.38 (2)degrees. In the crystal, weak intermolecular C-H…O hydrogen bonds link the molecules.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 57-50-1. The above is the message from the blog manager. SDS of cas: 57-50-1.

Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

Chemistry is an experimental science, Formula: C12H22O11, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 57-50-1, Name is Sucrose, molecular formula is C12H22O11, belongs to dioxole compound. In a document, author is Ocola, Esther J..

Anomeric Effect in Five-Membered Ring Molecules: Comparison of Theoretical Computations and Experimental Spectroscopic Results

As demonstrated in previous spectroscopic studies of 1,3-dioxole [J. Am. Chem. Soc., 1993, 115, 12132-12136] and 1,3-benzodioxole [J. Am. Chem. Soc., 1999, 121, 5056-5062], analysis of the ring-puckering potential energy function (PEF) of a pseudo-four-membered ring molecule can provide insight into understanding the magnitude of the anomeric effect. In the present study, high-level CCSD/cc-pVTZ and somewhat lower-level MP2/cc-pVTZ ab initio computations have been utilized to calculate the PEFs for 1,3-dioxole and 1,3-benzodioxole and 10 related molecules containing sulfur and selenium atoms and possessing the anomeric effect. The potential energy parameters derived for the PEFs directly provide a comparison of the relative magnitudes of the anomeric effect for molecules possessing OCO, OCS, OCSe, SCS, SCSe, and SeCSe linkages. The torsional potential energies produced by the anomeric effect for these linkages were estimated to range from 5.97 to 1.91 kcal/mol. The ab initio calculations also yielded the structural parameters, barriers to planarity, and ring-puckering angles for each of the 12 molecules studied. Based on the refined structural parameters for 1,3-dioxole and 1,3-benzodioxole, improved PEFs for these molecules were also calculated. The calculations also support the conclusion that the relatively low barrier to planarity of 1,3-benzodioxole results from competitive interactions between its benzene ring and the oxygen atom p orbitals.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 57-50-1, in my other articles. Formula: C12H22O11.

Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

Reference of 57-50-1, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 57-50-1, Name is Sucrose, SMILES is O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@H]1O[C@@]2(CO)[C@H]([C@@H]([C@@H](CO)O2)O)O, belongs to dioxole compound. In a article, author is Chang, Hong-Tai, introduce new discover of the category.

Highly efficient cyclization of o-iodobenzoates with aldehydes catalyzed by cobalt bidentate phosphine complexes: A novel entry to chiral phthalides

Methyl 2-iodobenzoates 1a-c undergo cyclization reactions with various aromatic aldehydes 2 a-m (RC6H4CHO: R=H 2a, 4-CH3 2b, 4-tBu 2 c, 4-OMe 2 d, 3-OMe 2 e, 4-Cl 2 f, 4-CF3 2g, 4-CN 2h, 4-Ph 2i; benzo[d][1,3]dioxole-5-carbaldehyde (2j), -napthaldehyde (2k), benzofuran-2-carbaldehyde (21), and isonicotinaldehyde (2m)) in the presence of [CoI2(dppe)] (dppe = 1,2-bis(diphenylphosphino)ethane) and Zn powder in dry THF at 75 degrees C for 24 h to give the corresponding phthalide derivatives 3a-m and 3q-t in good to excellent yields. Under similar reaction conditions, less reactive aliphatic aldehydes, heptanal (2n), butyraldehyde (2o), and 2-phenylacetaldehyde (2p) also underwent cyclization reactions with la to provide 3n-p, respectively, in fair to good yields. The catalytic reaction can be further extended to cinnamyl aldehyde (2q) with la to give the corresponding phthalide derivative 3u. This synthetic method is compatible with a variety of functional groups on the aryl ring of 2. The high efficiency of the cobalt catalyst containing a dppe (dppe=1,2-bis(diphenylphosphino)ethane) ligand encouraged us to investigate the asymmetric version of the present catalytic reaction by employing bidentate chiral ligands. Thus, aromatic aldehydes 2a-c, 2f, and 2g undergo cyclization with 2-iodobenzoate (1a) smoothly in the presence of [CoI2(S,S)-dipamp}] ((SS)-dipamp(1S,2S)-(+)-bis[2-methoxyphenyl]phenylphosphino)ethane) and zinc powder in THF at 75 degrees C for 24 h, giving the corresponding (S)-phthalides 4a-e in 81-89% yields with 70-98% ee. A possible mechanism for the present catalytic reaction is proposed.

Reference of 57-50-1, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 57-50-1.

Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

57-50-1, Name is Sucrose, molecular formula is C12H22O11, belongs to dioxole compound, is a common compound. In a patnet, author is Mansour, Eman, once mentioned the new application about 57-50-1, Computed Properties of C12H22O11.

Synthesis, Docking and Anticancer Evaluation of New Pyridine-3-Carbonitrile Derivatives

N’-(2-((4-(Benzo[d][1, 3]dioxol-5-yl)-3-cyano-6-(naphthalen-2-yl)-pyridin-2-yl)oxy)- acetyl)benzohydrazide (6) and hydrazide derivatives (7-10) were synthesized via reaction of 3-cyano-pyridinacetohydrazide (5) with benzoylchloride and the appropriate aldehyde, respectively. Also, 4-(Benzo[d][1, 3]dioxol-5-yl)-2-(2-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)-2-oxoethoxy)-6-(naphthalen-2-yl) nicotinonitrile (11) was prepared through reaction of (5) with ethylacetoacetate. In addition, the hydrazide 5 was used as a starting material for synthesizing other nicotinonitrile derivatives (12, 13) and acetohydrazides (14, 15). Moreover, new 2, 5-disubsitituted-1,3,4-oxadiazoles (16, 17) were furnished by the reaction of (5) with benzoic acid derivatives. The cytotoxicity for some new compounds was investigated against human breast cancer MCF-7 and MDA-MB-231 cell lines at concentrations (0, 10, 20, 40, 60, 80, and 100 mu g/ml) using MTT assay. Compounds (4, 9, 14 and 17) were recorded the lowest half-maximal inhibitory concentrations (IC50s) against MCF-7 and MDA-MB-231 cell lines via cytotoxicity assays. These results were confirmed using molecular docking experiments. From the previous observations, we suggested that our synthesized compounds could be of great potential against breast cancer cells.

If you’re interested in learning more about 57-50-1. The above is the message from the blog manager. Computed Properties of C12H22O11.

Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

Let¡¯s face it, organic chemistry can seem difficult to learn. Especially from a beginner¡¯s point of view. Like 57-50-1, Name is Sucrose. In a document, author is Belov, N., introducing its new discovery. Product Details of 57-50-1.

Gas permeation, diffusion, sorption and free volume of poly(2-trifluoromethyl-2-pentafluoroethyl-1,3-perfluorodioxole)

Synthesis of a homopolymer based on perfluoro(2-methyl-2-ethyl-dioxole) was performed at 50-60 degrees C and high pressure (10 kbar). The polymer is amorphous with high glass transition temperature (235 degrees C), low (among perfluoropolymers) density (1.83 g/cm(3)) and sufficiently good film-forming properties. The structure of the polymer was tested by F-19- and IR-spectroscopies. Positron annihilation life-time spectroscopy results suggest large size of free volume elements approaching that for perfluorinated copolymer AF2400. The homopolymer is characterized by high gas permeability, diffusion and solubility coefficients and can be considered as good potential material for various membrane gas separations.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 57-50-1 help many people in the next few years. Product Details of 57-50-1.

Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem