Category: 56786-63-1

New Advances in Chemical Research in 2021. COA of Formula: https://www.ambeed.com/products/56786-63-1.html, Chemistry involves the study of all things chemical – chemical processes, chemical compositions and chemical manipulation – in order to better understand the way in which materials are structured, how they change and how they react in certain situations. 56786-63-1, Name is (2AR,2’R,4S,5’R,6aR,6bS,8aS,8bR,9S,11aS,12aS,12bS)-2a,4-dihydroxy-5′,6a,8a,9-tetramethylicosahydrospiro[naphtho[2′,1′:4,5]indeno[2,1-b]furan-10,2′-pyran]-2(11aH)-one, SMILES is [H][C@]1(O[C@@]2(OC[C@H](C)CC2)[C@H]3C)C[C@@]4([H])[C@]5([H])CC([C@@]6(O)C[C@@H](O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@]13[H])=O, belongs to dioxole compound. In a article, author is Tanaka, Ken, introduce new discover of the category.

A cationic rhodium(I)/(R)-Segphos (R) [(4A’-bi-1,3-benzo-dioxole)-5,5′-diylbis(diphenylphosphine)] complex catalyzes the highly enantioselective [4+2] annulation of 2-alkynyl-benzaldehydes with acyl phosphonates, leading to benzopyranones with a phosphonate-substituted quaternary carbon center in moderate to high yields with excellent ee’s.

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Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

New discoveries in chemical research and development in 2021. Irreversible inhibitors are therefore the equivalent of poisons in heterogeneous catalysis. 56786-63-1, Name is (2AR,2’R,4S,5’R,6aR,6bS,8aS,8bR,9S,11aS,12aS,12bS)-2a,4-dihydroxy-5′,6a,8a,9-tetramethylicosahydrospiro[naphtho[2′,1′:4,5]indeno[2,1-b]furan-10,2′-pyran]-2(11aH)-one, SMILES is [H][C@]1(O[C@@]2(OC[C@H](C)CC2)[C@H]3C)C[C@@]4([H])[C@]5([H])CC([C@@]6(O)C[C@@H](O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@]13[H])=O, in an article , author is NEMOTO, H, once mentioned of 56786-63-1, Formula: https://www.ambeed.com/products/56786-63-1.html.

A novel synthesis of the quaternary substituted chiral cyclobutanone (9) was achieved by the concerted ring expansion of the chiral cyclopropyl epoxide (8) which lead to a formal total synthesis of (-)-frontalin (14).

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Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

New research progress on 56786-63-1 in 2021. Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. In an article, author is Wohlfart, Paulus, once mentioned the application of 56786-63-1, COA of Formula: https://www.ambeed.com/products/56786-63-1.html, Name is (2AR,2’R,4S,5’R,6aR,6bS,8aS,8bR,9S,11aS,12aS,12bS)-2a,4-dihydroxy-5′,6a,8a,9-tetramethylicosahydrospiro[naphtho[2′,1′:4,5]indeno[2,1-b]furan-10,2′-pyran]-2(11aH)-one, molecular formula is C27H42O5, molecular weight is 446.6194, MDL number is MFCD00273330, category is dioxole. Now introduce a scientific discovery about this category.

Many cardiovascular diseases are associated with reduced levels of bioactive nitric oxide ( NO) and an uncoupling of oxygen reduction from NO synthesis in endothelial NO synthase ( eNOS uncoupling). In human endothelial EA.hy 926 cells, two small-molecular-weight compounds with related structures, 4-fluoro-N-indan-2-yl-benzamide ( CAS no. 291756-32-6; empirical formula C16H14FNO; AVE9488) and 2,2-difluoro-benzo[1,3] dioxole-5-carboxylic acid indan-2-ylamide( CAS no. 450348-85-3; empirical formula C17H13F2NO3; AVE3085), enhanced eNOS promoter activity in a concentration-dependent manner; with the responsible cis-element localized within the proximal 263 base pairs of the promoter region. RNA interference-mediated knockdown of the transcription factor Sp1 significantly reduced the basal activity of eNOS promoter, but it did not prevent the transcription activation by the compounds. Enhanced transcription of eNOS by AVE9488 in primary human umbilical vein endothelial cells was associated with increased levels of eNOS mRNA and protein expression, as well as increased bradykinin-stimulated NO production. In both wild-type C57BL/6J mice and apolipoprotein E-knockout ( apoE-KO) mice, treatment with AVE9488 resulted in enhanced vascular eNOS expression. In apoE-KO mice, but not in eNOS-knockout mice, treatment with AVE9488 reduced cuff-induced neointima formation. A 12-week treatment with AVE9488 or AVE3085 reduced atherosclerotic plaque formation in apoE-KO mice, but not in apoE/eNOS-double knockout mice. Aortas from apoE-KO mice showed a significant generation of reactive oxygen species. This was partly prevented by nitric-oxide inhibitor N-omega- nitro-L-arginine methyl ester, indicating eNOS uncoupling. Treatment of mice with AVE9488 enhanced vascular content of the essential eNOS cofactor ( 6R)-5,6,7,8- tetrahydro-L-biopterin and reversed eNOS uncoupling. The combination of an up-regulated eNOS expression and a reversal of eNOS uncoupling is probably responsible for the observed vasoprotective properties of this new type of compounds.

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Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

New Advances in Chemical Research, April 2021. Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media. 56786-63-1, Name is (2AR,2’R,4S,5’R,6aR,6bS,8aS,8bR,9S,11aS,12aS,12bS)-2a,4-dihydroxy-5′,6a,8a,9-tetramethylicosahydrospiro[naphtho[2′,1′:4,5]indeno[2,1-b]furan-10,2′-pyran]-2(11aH)-one, SMILES is [H][C@]1(O[C@@]2(OC[C@H](C)CC2)[C@H]3C)C[C@@]4([H])[C@]5([H])CC([C@@]6(O)C[C@@H](O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@]13[H])=O, belongs to dioxole compound. In a document, author is Milani, Alberto, introduce the new discover, HPLC of Formula: https://www.ambeed.com/products/56786-63-1.html.

The supramolecular solid state structure of Na+, K+, Ca2+ and NH4+ salts of difluoro((2,2,4,5-tetrafluoro-5-(trifluoromethoxy)-1.3-dioxolan-4-yl)oxy)acetic acid have been investigated by means of IR and Raman vibrational spectroscopy, and Density Functional Theory (DFT) calculations on suitable molecular models. In the case of NH4+ salts, additional insights have been provided by X-Ray diffraction measurements on crystalline powders. Based on the analysis of IR and Raman spectra, the structure of the different salts at the molecular level is identified. In NH4+ salts, the spectra indicate the existence of different stable complexes, while for the other salts only one type of aggregation is observed. For NH4+ salts, it has been analyzed the effect of solvation in water, focusing on the specific features shown by the IR spectrum: this gave a further insight on the peculiar aggregation properties observed. For all the cases-studied, DFT calculations gave a satisfactory interpretation of the experimental vibrational spectra based on the structure of different models of molecular complexes, and allowed the identification of characteristic marker bands related to different supra-molecular architectures. (C) 2012 Elsevier B.V. All rights reserved.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 56786-63-1. HPLC of Formula: https://www.ambeed.com/products/56786-63-1.html.

Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

New Advances in Chemical Research in 2021. Enzyme inhibitors cause a decrease in the reaction rate of an enzyme-catalyzed reaction by binding to a specific portion of an enzyme and thus slowing or preventing a reaction from occurring. 56786-63-1, Name is (2AR,2’R,4S,5’R,6aR,6bS,8aS,8bR,9S,11aS,12aS,12bS)-2a,4-dihydroxy-5′,6a,8a,9-tetramethylicosahydrospiro[naphtho[2′,1′:4,5]indeno[2,1-b]furan-10,2′-pyran]-2(11aH)-one, SMILES is [H][C@]1(O[C@@]2(OC[C@H](C)CC2)[C@H]3C)C[C@@]4([H])[C@]5([H])CC([C@@]6(O)C[C@@H](O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@]13[H])=O, in an article , author is Li, Yi-Ming, once mentioned of 56786-63-1, Electric Literature of 56786-63-1.

In order to discover and develop the new HIV-1 NNRTIs, a series of 5-alkyl-6-(benzo[d][1,3]dioxol-5-ylalkyl)-2mercaptopyrimidin-4(3H)-ones was synthesized and screened for their in vitro cytotoxicity against HIV-1. Most of the compounds we synthetized showed high activity against wild-type HIV-1 strain (IIIB) while IC50 values are in the range of 0.06-12.95 mu M. Among them, the most active HIV-1 inhibitor was compound 6-(benzo[d][1,3] dioxol-5-ylmethyl)-5-ethyl-2-((2-(4-hydroxyphenyl)-2-oxoethyl)thio)pyrimidin-4(3H)-one (5b), which exhibited similar HIV-1 inhibitory potency (IC50 = 0.06 mu M, CC50 = 96.23 mu M) compared with nevirapine (IC50 = 0.04 mu M, CC50 200 mu M) and most of compounds exhibited submicromolar IC50 values indicating they were specific RT inhibitors. The compounds 5b, 6-(benzo[d] [1,3]dioxol-5-yl)-5-ethyl-2-((2-(4-hydroxyphenyl)2-oxoethyl)thio)pyrimidin-4(3H)-one (5c) and 4-(2-((4-(benzo[d][1,3]dioxol-5-ylmethyl)-5-ethyl-6-oxo-1,6-dihydropyrimidin-2-yl)thio)acetyl)phenylbenzo[d][1,3]dioxole-5-carboxylate (5r) were selected for further study. It was found that all of them had little toxicity to peripheral blood mononuclear cell (PBMC), and had a good inhibitory effect on the replication of HIV-1 protease inhibitor resistant strains, fusion inhibitor resistant strains and nucleosides reverse transcriptase inhibitor resistant strains, as well as on clinical isolates. Besides, compound 5b and 5c showed inhibition of HIV-1 RT RNA-dependent DNA polymerization activity and DNA-dependent DNA polymerization activity, while compound 5r only showed inhibition of HIV DNA-dependent DNA polymerization activity, which was different from classical reverse transcriptase inhibitors. Our study which offered the preliminary structure-activity relationships and modeling studies of these new compounds has provided the valuable avenues for future molecular optimization.

Electric Literature of 56786-63-1, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 56786-63-1.

Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

New Advances in Chemical Research, April 2021. Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. Related Products of 56786-63-156786-63-1, Name is (2AR,2’R,4S,5’R,6aR,6bS,8aS,8bR,9S,11aS,12aS,12bS)-2a,4-dihydroxy-5′,6a,8a,9-tetramethylicosahydrospiro[naphtho[2′,1′:4,5]indeno[2,1-b]furan-10,2′-pyran]-2(11aH)-one, SMILES is [H][C@]1(O[C@@]2(OC[C@H](C)CC2)[C@H]3C)C[C@@]4([H])[C@]5([H])CC([C@@]6(O)C[C@@H](O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@]13[H])=O, belongs to dioxole compound. In a article, author is Duan, Yanwei, introduce new discover of the category.

Berberine is a traditional medicine that has multiple medicinal and agricultural applications. However, little is known about whether berberine can be a bioactive molecule toward carbohydrate-active enzymes, which play numerous vital roles in the life process. In this study, berberine and its analogs were discovered to be competitive inhibitors of glycoside hydrolase family 20 -N-acetyl-d-hexosaminidase (GH20 Hex) and GH18 chitinase from both humans and the insect pest Ostrinia furnacalis. Berberine and its analog SYSU-1 inhibit insect GH20 Hex from O. furnacalis (OfHex1), with K-i values of 12 and 8.5 m, respectively. Co-crystallization of berberine and its analog SYSU-1 in complex with OfHex1 revealed that the positively charged conjugate plane of berberine forms – stacking interactions with Trp(490), which are vital to its inhibitory activity. Moreover, the 1,3-dioxole group of berberine binds an unexplored pocket formed by Trp(322), Trp(483), and Val(484), which also contributes to its inhibitory activity. Berberine was also found to be an inhibitor of human GH20 Hex (HsHexB), human GH18 chitinase (HsCht and acidic mammalian chitinase), and insect GH18 chitinase (OfChtI). Besides GH18 and GH20 enzymes, berberine was shown to weakly inhibit human GH84 O-GlcNAcase (HsOGA) and Saccharomyces cerevisiae GH63 -glucosidase I (ScGluI). By analyzing the published crystal structures, berberine was revealed to bind with its targets in an identical mechanism, namely via – stacking and electrostatic interactions with the aromatic and acidic residues in the binding pockets. This paper reports new molecular targets of berberine and may provide a berberine-based scaffold for developing multitarget drugs.

Related Products of 56786-63-1, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 56786-63-1.

Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

New Advances in Chemical Research, April 2021. Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media. 56786-63-1, Name is (2AR,2’R,4S,5’R,6aR,6bS,8aS,8bR,9S,11aS,12aS,12bS)-2a,4-dihydroxy-5′,6a,8a,9-tetramethylicosahydrospiro[naphtho[2′,1′:4,5]indeno[2,1-b]furan-10,2′-pyran]-2(11aH)-one, SMILES is [H][C@]1(O[C@@]2(OC[C@H](C)CC2)[C@H]3C)C[C@@]4([H])[C@]5([H])CC([C@@]6(O)C[C@@H](O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@]13[H])=O, belongs to dioxole compound. In a document, author is Aitken, R. Alan, introduce the new discover, Formula: https://www.ambeed.com/products/56786-63-1.html.

The most important new developments in the chemistry of 1,3-dioxole- and 1,3-oxathiole-based ring systems over the period 2007-2012 are described in four major sections with 200 literature references. Properties such as theoretical and experimental structure determination are discussed including X-ray structure determination and nuclear magnetic resonance studies. Reactivity is considered in the categories of nucleophilic attack at ring carbon atoms, ring deprotonation, radical and carbene reactions and halogenation, and reactivity at ring substituents. Synthesis is covered in detail with new methods categorized according to the number of ring bonds formed and the fragments involved. Finally, applications are described for individual compounds in areas such as polymers, electronics, batteries, chiral NMR shift reagents, chiral catalysts, chiral ligands, and pharmaceuticals.

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Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

New research progress on 56786-63-1 in 2021. Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. In an article, author is Suarez, D, once mentioned the application of 56786-63-1, Recommanded Product: (2AR,2’R,4S,5’R,6aR,6bS,8aS,8bR,9S,11aS,12aS,12bS)-2a,4-dihydroxy-5′,6a,8a,9-tetramethylicosahydrospiro[naphtho[2′,1′:4,5]indeno[2,1-b]furan-10,2′-pyran]-2(11aH)-one, Name is (2AR,2’R,4S,5’R,6aR,6bS,8aS,8bR,9S,11aS,12aS,12bS)-2a,4-dihydroxy-5′,6a,8a,9-tetramethylicosahydrospiro[naphtho[2′,1′:4,5]indeno[2,1-b]furan-10,2′-pyran]-2(11aH)-one, molecular formula is C27H42O5, molecular weight is 446.6194, MDL number is MFCD00273330, category is dioxole. Now introduce a scientific discovery about this category.

A theoretical analysis on planar and puckered-ring conformations of cyclopentadiene, 2,3-dihydrofuran, and 1,3-dioxole is carried out to test the conclusion of Laane and co-workers (J. Am. Chem. Soc. 1993, 115, 12132) that the unexpected nonplanarity of 1,3-dioxole must be attributed to the anomeric effect. MP4/6-31G**/IMP2/6-31G** calculations and NBO analysis show that delocalization involving the oxygen lone pairs and the C-O antibonding orbital, commonly associated with the anomeric effect, plays a decisive role in explaining the above-mentioned experimental fact. A careful analysis of the dipole-dipole interaction energy indicates that, in the present case, the electrostatic theory does not help to rationalize the experimentally observed puckered-ring conformation of 1,3-dioxole.

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Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

New discoveries in chemical research and development in 2021. Irreversible inhibitors are therefore the equivalent of poisons in heterogeneous catalysis. 56786-63-1, Name is (2AR,2’R,4S,5’R,6aR,6bS,8aS,8bR,9S,11aS,12aS,12bS)-2a,4-dihydroxy-5′,6a,8a,9-tetramethylicosahydrospiro[naphtho[2′,1′:4,5]indeno[2,1-b]furan-10,2′-pyran]-2(11aH)-one, SMILES is [H][C@]1(O[C@@]2(OC[C@H](C)CC2)[C@H]3C)C[C@@]4([H])[C@]5([H])CC([C@@]6(O)C[C@@H](O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@]13[H])=O, in an article , author is Yang, Zhongzhen, once mentioned of 56786-63-1, SDS of cas: 56786-63-1.

Palmatine and berberine, structurally similar isoquinoline alkaloids exhibiting a broad range of biological activities, were recently found to inhibit p300 histone acetyltransferase (HAT), a potential therapeutic target for treating transcriptional activator-driven malignancies and diseases. Here, we report the first total synthesis of B-homo palmatine (11a) and berberine (11b) derivatives, which were synthesized from 3,4-dimethoxybenzaldehyde (1a) and benzo[d][1,3]dioxole-5-carbaldehyde (1b) in nine steps in 13.8 and 16.9% overall yields, respectively. A number of other new B-homo palmatine and berberine derivatives were also prepared. These derivatives display good inhibitory activity against p300 HAT; compound 12a manifests the most potent inhibition with an IC50 value of 0.42 mu m. Cell-based assays revealed that 12a exhibits certain inhibitory activity against HCG27, HT1080, and Z-138 cell lines, and no visible activity towards other cancer cell lines tested, reflecting that 12a has low cytotoxicity and acts against some types of cancer cells.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 56786-63-1. SDS of cas: 56786-63-1.

Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

Chemical Research Letters, April 2021. As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. Computed Properties of https://www.ambeed.com/products/56786-63-1.html56786-63-1, Name is (2AR,2’R,4S,5’R,6aR,6bS,8aS,8bR,9S,11aS,12aS,12bS)-2a,4-dihydroxy-5′,6a,8a,9-tetramethylicosahydrospiro[naphtho[2′,1′:4,5]indeno[2,1-b]furan-10,2′-pyran]-2(11aH)-one, SMILES is [H][C@]1(O[C@@]2(OC[C@H](C)CC2)[C@H]3C)C[C@@]4([H])[C@]5([H])CC([C@@]6(O)C[C@@H](O)CC[C@]6(C)[C@@]5([H])CC[C@]4(C)[C@]13[H])=O, belongs to dioxole compound. In a article, author is Boshta, Nader M., introduce new discover of the category.

Highly functionalized catechol ketals exhibiting either a tert-butyl moiety or a spiro center in position 2 are synthesized by ketalization and functionalized in a sequence of subsequent transformations. By a specific ketalization protocol catechol ketals of enolizable beta-keto esters can be prepared. With the succeeding steps these compounds incorporate moieties, which are not compatible and accessible by direct ketalization of catechol. (C) 2009 Elsevier Ltd. All rights reserved.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 56786-63-1. Computed Properties of https://www.ambeed.com/products/56786-63-1.html.

Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem