Category: 455-70-9

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《N-Oxides of nicotinic acid and its esters》. Authors are Clemo, G. R.; Koenig, H..The article about the compound:Methyl 5-fluoro-3-pyridinecarboxylatecas:455-70-9,SMILESS:COC(=O)C1=CC(F)=CN=C1).Computed Properties of C7H6FNO2. Through the article, more information about this compound (cas:455-70-9) is conveyed.

Nicotinic acid (I) (1 part) in 3 parts glacial AcOH and 3 parts H2O2, heated 3 hrs. on the water bath, gives 70-80% of the N-oxide (II), pale yellow, m. 249° (decomposition); impure II, heated at 100°, decompose spontaneously. II (1 g.) in 20 ml. MeOH, saturated with HCl at 0° and refluxed 2 hrs., gives 0.5 g. of the Me ester, m. 97°; Et ester (III), m. 99.5°. The Et ester of I (2 g.), 10 ml. AcOH, and 30 ml. H2O2, heated 3 hrs. on the water bath, give 1.1 g. III.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Xing, Bo; Ni, Chuanfa; Hu, Jinbo researched the compound: Methyl 5-fluoro-3-pyridinecarboxylate( cas:455-70-9 ).Name: Methyl 5-fluoro-3-pyridinecarboxylate.They published the article 《Hypervalent Iodine(III) Catalyzed Balz-Schiemann Fluorination under Mild Conditions》 about this compound( cas:455-70-9 ) in Angewandte Chemie, International Edition. Keywords: arenediazonium tetrafluoroborate Balz Schiemann fluorination hypervalent iodine catalyst; fluoride aryl preparation; Balz-Schiemann reaction; aryl fluorides; diazonium salts; fluorination; iodine. We’ll tell you more about this compound (cas:455-70-9).

An unprecedented hypervalent iodine(III)-catalyzed Balz-Schiemann reaction was described. In the presence of a hypervalent iodine compound, the fluorination reaction proceeded under mild conditions (25-60 °C), and featured a wide substrate scope and good functional-group compatibility.

There is still a lot of research devoted to this compound(SMILES：COC(=O)C1=CC(F)=CN=C1)Name: Methyl 5-fluoro-3-pyridinecarboxylate, and with the development of science, more effects of this compound(455-70-9) can be discovered.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

HPLC of Formula: 455-70-9. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: Methyl 5-fluoro-3-pyridinecarboxylate, is researched, Molecular C7H6FNO2, CAS is 455-70-9, about Hypervalent Iodine(III) Catalyzed Balz-Schiemann Fluorination under Mild Conditions. Author is Xing, Bo; Ni, Chuanfa; Hu, Jinbo.

An unprecedented hypervalent iodine(III)-catalyzed Balz-Schiemann reaction was described. In the presence of a hypervalent iodine compound, the fluorination reaction proceeded under mild conditions (25-60 °C), and featured a wide substrate scope and good functional-group compatibility.

There is still a lot of research devoted to this compound(SMILES：COC(=O)C1=CC(F)=CN=C1)HPLC of Formula: 455-70-9, and with the development of science, more effects of this compound(455-70-9) can be discovered.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Methyl 5-fluoro-3-pyridinecarboxylate( cas:455-70-9 ) is researched.Name: Methyl 5-fluoro-3-pyridinecarboxylate.Carlson, Lars A.; Hedbom, Christina; Helgstrand, Erik; Sjoberg, Berndt; Stjernstrom, Nils E. published the article 《Potential hypolipidemic agents. III. Heterocyclic compounds affecting free fatty acid mobilization in vivo》 about this compound( cas:455-70-9 ) in Acta Pharmaceutica Suecica. Keywords: fatty acid mobilization fluoronicotinate blood; fluoropyridylacetate fatty acid mobilization blood; methylpyrazole fatty acid mobilization blood. Let’s learn more about this compound (cas:455-70-9).

Compounds such as 3-methyl-5-isoxazolecarboxylic acid [4857-42-5], 5-fluoronicotinic acid [402-66-4], 5-fluoro-3-pyridylacetic acid [38129-24-7], and 3-methylpyrazole [1453-58-3] exhibited the highest inhibition of free fatty acid mobilization in blood among 188 heterocyclic compounds tested in dogs, while compounds such as 5-methyl-3-isoxazolecarboxylic acid [3405-77-4], 2-fluoronicotinic acid [393-55-5], and 3-aminobenzoic acid [99-05-8] had no effect on free fatty acid mobilization.

If you want to learn more about this compound(Methyl 5-fluoro-3-pyridinecarboxylate)Name: Methyl 5-fluoro-3-pyridinecarboxylate, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(455-70-9).

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Recommanded Product: 455-70-9. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Methyl 5-fluoro-3-pyridinecarboxylate, is researched, Molecular C7H6FNO2, CAS is 455-70-9, about Discovery of pyridone-containing imidazolines as potent and selective inhibitors of neuropeptide Y Y5 receptor. Author is Ando, Makoto; Sato, Nagaaki; Nagase, Tsuyoshi; Nagai, Keita; Ishikawa, Shiho; Takahashi, Hirobumi; Ohtake, Norikazu; Ito, Junko; Hirayama, Mioko; Mitobe, Yuko; Iwaasa, Hisashi; Gomori, Akira; Matsushita, Hiroko; Tadano, Kiyoshi; Fujino, Naoko; Tanaka, Sachiko; Ohe, Tomoyuki; Ishihara, Akane; Kanatani, Akio; Fukami, Takehiro.

A series of 2-pyridone-containing imidazoline derivatives was synthesized and evaluated as neuropeptide Y Y5 receptor antagonists. Optimization of the 2-pyridone structure on the 2-position of the imidazoline ring led to identification of 1-(difluoromethyl)-5-[(4S,5S)-4-(4-fluorophenyl)-4-(6-fluoropyridin-3-yl)-5-methyl-4,5-dihydro-1H-imidazol-2-yl]pyridin-2(1H)-one (7m, I). Compound 7m displayed statistically significant inhibition of food intake in an agonist-induced food intake model in SD rats and no adverse cardiovascular effects in anesthetized dogs. In addition, markedly higher brain penetrability and a lower plasma Occ90 value were observed in P-gp-deficient mdr1a (-/-) mice compared to mdr1a (+/+) mice after oral administration of 7m.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Application In Synthesis of Methyl 5-fluoro-3-pyridinecarboxylate. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: Methyl 5-fluoro-3-pyridinecarboxylate, is researched, Molecular C7H6FNO2, CAS is 455-70-9, about PhenoFluorMix: Practical Chemoselective Deoxyfluorination of Phenols. Author is Fujimoto, Teppei; Ritter, Tobias.

A practical deoxyfluorination with novel deoxyfluorinating reagent PhenoFluorMix, a mixture of N,N’-1,3-bis(2,6-diisopropylphenyl)chloroimidazolium chloride and CsF, is presented. PhenoFluorMix overcomes the challenges associated with hydrolysis of PhenoFluor. PhenoFluorMix does not hydrolyze, is readily available on decagram scale, and is storable in air. In this paper, we demonstrate the practicality of the reagent and exhibit the deoxyfluorination of a variety of phenols and heterocycles.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem