Category: 4360-63-8

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Bromomethyl-1,3-dioxolane, is researched, Molecular C4H7BrO2, CAS is 4360-63-8, about Enantioselective Synthesis of 7(S)-Hydroxydocosahexaenoic Acid, a Possible Endogenous Ligand for PPARα, the main research direction is hydroxydocosahexaenoic acid synthesis.Reference of 2-Bromomethyl-1,3-dioxolane.

We report the first total synthesis of the polyunsaturated fatty acid 7-hydroxydocosahexaenoic acid (7-HDHA) in racemic form and the enantioselective synthesis of 7-(S)-HDHA. Both syntheses follow a convergent approach that unites the C1-C9 and C10-C22 fragments using Sonogashira coupling and Boland reduction as key steps. These syntheses enabled the unambiguous characterization of this natural product for the first time and helped establish 7(S)-HDHA as a possible endogenous ligand for peroxisome proliferator-activated receptor alpha.

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1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Safety of 2-Bromomethyl-1,3-dioxolane. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Bromomethyl-1,3-dioxolane, is researched, Molecular C4H7BrO2, CAS is 4360-63-8, about Assembly of multicyclic isoquinoline scaffolds from pyridines: formal total synthesis of fredericamycin A. Author is Wang, Fang-Xin; Yan, Jia-Lei; Liu, Zhixin; Zhu, Tingshun; Liu, Yingguo; Ren, Shi-Chao; Lv, Wen-Xin; Jin, Zhichao; Chi, Yonggui Robin.

The construction of an isoquinoline skeleton typically starts with benzene derivatives as substrates with the assistance of acids or transition metals. Disclosed here is a concise approach to prepare isoquinoline analogs by starting with pyridines to react with β-ethoxy α,β-unsaturated carbonyl compounds under basic conditions. Multiple substitution patterns and a relatively large number of functional groups (including those sensitive to acidic conditions) can be tolerated the method. In particular, protocol allows for efficient access to tricyclic isoquinolines found in hundreds of natural products with interesting bioactivities. The efficiency and operational simplicity of introducing structural complexity into the isoquinoline frameworks can likely enable the collective synthesis of a large set of natural products. Here show that fredericamycin A could be obtained via a short route by using isoquinoline synthesis as a key step.

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1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Bromomethyl-1,3-dioxolane(SMILESS: BrCC1OCCO1,cas:4360-63-8) is researched.Name: 5-(11bR)-Dinaphtho[2,1-d:1′,2′-f][1,3,2]dioxaphosphepin-4-yl-5H-dibenz[b,f]azepine. The article 《Efficient synthesis of α-branched purine-based acyclic nucleosides: scopes and limitations of the method》 in relation to this compound, is published in Molecules. Let’s take a look at the latest research on this compound (cas:4360-63-8).

An efficient route to acylated acyclic nucleosides containing a branched hemiaminal ether moiety was reported via three-component alkylation of N-heterocycle (purine nucleobase) with acetal (cyclic or acyclic, variously branched) and anhydride (preferentially acetic anhydride). The procedure employed cheap and easily available acetals, acetic anhydride, and trimethylsilyl trifluoromethanesulfonate (TMSOTf). The multi-component reaction was carried out in acetonitrile at room temperature for 15 min and provides moderate to high yields (up to 88%) of diverse acyclonucleosides branched at the aliphatic side chain. The procedure exhibited a broad substrate scope of N-heterocycles and acetals, and, in the case of purine derivatives, also excellent regioselectivity, giving almost exclusively N-9 isomers.

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1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Design, synthesis, and biological evaluation of novel urolithins derivatives as potential phosphodiesterase II inhibitors, published in 2021-12-31, which mentions a compound: 4360-63-8, Name is 2-Bromomethyl-1,3-dioxolane, Molecular C4H7BrO2, Application of 4360-63-8.

A series of urolithins derivatives I (R = Et, Pr, (2-fluorophenyl)methyl, etc.) and II (R = Et, i-Pr, oxolan-2-ylmethyl, etc.) were designed and synthesized, and their structures have been confirmed by 1H NMR, 13C NMR, and HR-MS. The inhibitory activity of these derivatives I and II on phosphodiesterase II (PDE2) was thoroughly studied with 3-hydroxy-8-methyl-6H-benzo[C]chromen-6-one and 3-hydroxy-7,8,9,10-tetrahydro-6H-benzo[C] chromen-6-one as the lead compounds The biol. activity test showed that compound I (R = n-pentyl) had the best inhibitory activity on PDE2 with an IC50 of 33.95μM. This study provides a foundation for further structural modification and transformation of urolithins to obtain PDE2 inhibitor small mols. with better inhibitory activity.

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1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Pastor, Miryam; Vayer, Marie; Weinstabl, Harald; Maulide, Nuno published an article about the compound: 2-Bromomethyl-1,3-dioxolane( cas:4360-63-8,SMILESS:BrCC1OCCO1 ).Recommanded Product: 2-Bromomethyl-1,3-dioxolane. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:4360-63-8) through the article.

Herein, a general electrochem. method to access unsym. 3,3-disubstituted oxindoles I (R1 = Me, Ph, Bn, cyclopentyl, etc.; R2 = Me, phenylethyl, Bn, etc.) by direct C-H functionalization where the oxindole fragment behaves as an electrophile was reported. This Umpolung approach does not rely on stoichiometric oxidants and proceeds under mild, environmentally benign conditions. Importantly, it enables the functionalization of these scaffolds through C-O, and by extension to C-C or even C-N bond formation.

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1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 4360-63-8, is researched, Molecular C4H7BrO2, about Transition-Metal-Free Deconstructive Lactamization of Piperidines, the main research direction is piperidine regioselective Baeyer Villiger oxidation decarboxylative intramol translactamization green; pyrrolidinone one pot preparation; Baeyer-Villiger oxidation; deconstructive functionalization; nitrogen heterocycles; piperidines; pyrrolidinones.Reference of 2-Bromomethyl-1,3-dioxolane.

One of the major challenges in organic synthesis is the activation or deconstructive functionalization of unreactive C(sp3)-C(sp3) bonds, which requires using transition or precious metal catalysts. We present here an alternative: the deconstructive lactamization of piperidines without using transition metal catalysts. To this end, we use 3-alkoxyamino-2-piperidones, which were prepared from piperidines through a dual C(sp3)-H oxidation, as transitory intermediates. Exptl. and theor. studies confirm that this unprecedented lactamization occurs in a tandem manner involving an oxidative deamination of 3-alkoxyamino-2-piperidones to 3-keto-2-piperidones, followed by a regioselective Baeyer-Villiger oxidation to give N-carboxyanhydride intermediates, which finally undergo a spontaneous and concerted decarboxylative intramol. translactamization.

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1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 2-Bromomethyl-1,3-dioxolane( cas:4360-63-8 ) is researched.Application of 4360-63-8.Chen, Peng; Zhang, Dianwen; Li, Meng; Wu, Qiong; Lam, Yuko P. Y.; Guo, Yan; Chen, Chen; Bai, Nan; Malhotra, Shipra; Li, Wei; O’Connor, Peter B.; Fu, Hongzheng published the article 《Discovery of novel, potent, isosteviol-based antithrombotic agents》 about this compound( cas:4360-63-8 ) in European Journal of Medicinal Chemistry. Keywords: preparation isosteviol derivative antithrombotic anticoagulant antiplatelet. Let’s learn more about this compound (cas:4360-63-8).

Thrombosis is a pathol. coagulation process and can lead to many serious thrombotic diseases. Here, we report a novel potent antithrombotic compound (6k) based on isosteviol with anticoagulant and antiplatelet activities. 6k selectively inhibited FXa (Ki = 0.015μM) against a panel of serine proteases and showed excellent anticoagulant activity (significant prolongation of ex vivo PT and aPTT over the vehicle, p < 0.01). 6k also significantly inhibited ADP-induced platelet aggregation in rats relative to the vehicle (p < 0.01). Furthermore, 6k exhibited potent ex vivo and in vivo antithrombotic activity in rats relative to the vehicle (p < 0.01 and p < 0.0001, resp.). Novel structure 6k, with potent antithrombotic activity, is expected to lead a promising approach for the development of antithrombotic agents. Compound(4360-63-8)Application of 4360-63-8 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(2-Bromomethyl-1,3-dioxolane), if you are interested, you can check out my other related articles.

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1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Tarasova, O. A.; Nedolya, N. A.; Albanov, A. I.; Trofimov, B. A. published the article 《Unexpected Formation of Thiophene in the Pyrrole Synthesis from Methoxyallene and Methyl Isothiocyanate》. Keywords: lithiated methoxyallene methyl isothiocyanate bromomethyl dioxolane copper cyclization; dioxolanylmethyl methoxythiophenamine preparation.They researched the compound: 2-Bromomethyl-1,3-dioxolane( cas:4360-63-8 ).HPLC of Formula: 4360-63-8. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:4360-63-8) here.

The sequential reaction of lithiated methoxyallene, Me isothiocyanate, and 2-(bromomethyl)-1,3-dioxolane in the presence of CuBr yields a 2,3-disubstituted thiophene instead of the expected pyrrole. The process was accomplished in one preparative stage and involved intramol. cyclization of the in situ-generated lithium allenylimidothioate and N-alkylation of the resulting lithium thienylamide. Varying the reaction conditions did not affect its route: in all cases, the only product was N-(1,3-dioxolan-2-ylmethyl)-3-methoxy-N-methylthiophen-2-amine.

Compound(4360-63-8)HPLC of Formula: 4360-63-8 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(2-Bromomethyl-1,3-dioxolane), if you are interested, you can check out my other related articles.

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Zhang, Minhao; Sayyad, Ashik A.; Dhesi, Anmol; Orellana, Arturo published an article about the compound: 2-Bromomethyl-1,3-dioxolane( cas:4360-63-8,SMILESS:BrCC1OCCO1 ).Recommanded Product: 2-Bromomethyl-1,3-dioxolane. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:4360-63-8) through the article.

We report the first total synthesis of the polyunsaturated fatty acid 7-hydroxydocosahexaenoic acid (7-HDHA) in racemic form and the enantioselective synthesis of 7-(S)-HDHA. Both syntheses follow a convergent approach that unites the C1-C9 and C10-C22 fragments using Sonogashira coupling and Boland reduction as key steps. These syntheses enabled the unambiguous characterization of this natural product for the first time and helped establish 7(S)-HDHA as a possible endogenous ligand for peroxisome proliferator-activated receptor alpha.

Compound(4360-63-8)Recommanded Product: 2-Bromomethyl-1,3-dioxolane received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(2-Bromomethyl-1,3-dioxolane), if you are interested, you can check out my other related articles.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-Bromomethyl-1,3-dioxolane(SMILESS: BrCC1OCCO1,cas:4360-63-8) is researched.Recommanded Product: 2-Bromomethyl-1,3-dioxolane. The article 《Optimization studies for hydrothermal gasification of partially burnt wood from forest fires for hydrogen-rich syngas production using Taguchi experimental design》 in relation to this compound, is published in Environmental Pollution (Oxford, United Kingdom). Let’s take a look at the latest research on this compound (cas:4360-63-8).

Forest fires significantly affect the wildlife, vegetation, composition and structure of the forests. This study explores the potential of partially burnt wood recovered in the aftermath of a recent Canadian forest fire incident as a feedstock for generating hydrogen-rich syngas through hydrothermal gasification. Partially burnt wood was gasified in hydrothermal conditions to study the influence of process temperature (300-500 °C), residence time (15-45 min), feed concentration (10-20 wt%) and biomass particle size (0.13 mm and 0.8 mm) using the statistical Taguchi method. Maximum hydrogen yield and total gas yield of 5.26 mmol/g and 11.88 mmol/g, resp. were obtained under optimized process conditions at 500 °C in 45 min with 10 wt% feed concentration using biomass particle size of 0.13 mm. The results from the mean of hydrogen yield show that the contribution of each exptl. factors was in the order of temperature > feed concentration > residence time > biomass particle size. Other gaseous products obtained at optimum conditions include CO2 (3.43 mmol/g), CH4 (3.13 mmol/g) and C2-C4 hydrocarbons (0.06 mmol/g).

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1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem