Category: 4360-63-8

Safety of 2-Bromomethyl-1,3-dioxolane. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Bromomethyl-1,3-dioxolane, is researched, Molecular C4H7BrO2, CAS is 4360-63-8, about Iridium-catalyzed enantioselective allylic substitution with aqueous solutions of nucleophiles. Author is Sandmeier, Tobias; Goetzke, F. Wieland; Krautwald, Simon; Carreira, Erick M..

The iridium-catalyzed asym. allylic substitution under biphasic conditions is reported. This approach allows the use of various unstable and/or volatile nucleophiles including hydrazines, methylamine, t-Bu hydroperoxide, N-hydroxylamine, α-chloroacetaldehyde and glutaraldehyde. This transformation provides rapid access to a broad range of products from simple starting materials in good yields and up to >99% ee and 20:1 d.r. Addnl., these products can be elaborated efficiently into a diverse set of cyclic and acyclic compounds, bearing up to four stereocenters. The iridium-catalyzed asym. allylic substitution under biphasic conditions is reported. This approach allows the use of various unstable and/or volatile nucleophiles including hydrazines, methylamine, t-Bu hydroperoxide, N-hydroxylamine, α-chloroacetaldehyde and glutaraldehyde. This transformation provides rapid access to a broad range of products from simple starting materials in good yields and up to >99% ee and 20:1 d.r.. Addnl., these products can be elaborated efficiently into a diverse set of cyclic and acyclic compounds, bearing up to four stereocenters.

There are many compounds similar to this compound(4360-63-8)Safety of 2-Bromomethyl-1,3-dioxolane. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Zeng, Guangkuo; Li, Yunqiang; Qiao, Baokun; Zhao, Xiaowei; Jiang, Zhiyong published the article 《Photoredox asymmetric catalytic enantioconvergent substitution of 3-chlorooxindoles》. Keywords: aminomethylene oxindole preparation enantioselective; chlorooxindole aryl glycine substitution photocatalyst.They researched the compound: 2-Bromomethyl-1,3-dioxolane( cas:4360-63-8 ).HPLC of Formula: 4360-63-8. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:4360-63-8) here.

An enantioconvergent substitution of 3-substituted 3-chlorooxindoles I (R = H, 6-Cl, 4-Br, 5-NO2, etc.; R1 = 4-FC6H4S(O)2, Me; Ar = Ph, naphthalen-2-yl, C6D5, etc.) with N-aryl glycines Ar1NHCH2C(O)OH [Ar1 = 4-methoxyphenyl, 4-methoxy-3-(trifluoromethyl)phenyl] under visible light irradiation is reported. A transition-metal-free cooperative catalysis platform with a dicyanopyrazine-derived chromophore (DPZ) as a photoredox catalyst and a chiral Bronsted acid catalyst is effective for these transformations, which involve a single-electron transfer redox step and an enantioselective radical coupling. A variety of valuable chiral 3-aminomethylene-3-substituted oxindoles II can be directly synthesized with high yields and enantioselectivities.

In addition to the literature in the link below, there is a lot of literature about this compound(2-Bromomethyl-1,3-dioxolane)HPLC of Formula: 4360-63-8, illustrating the importance and wide applicability of this compound(4360-63-8).

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthetic Route of C4H7BrO2. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Bromomethyl-1,3-dioxolane, is researched, Molecular C4H7BrO2, CAS is 4360-63-8, about A Practical and Versatile Method for the C-H Sulfenylation of Imidazo[1,2- a ]pyridines. Author is Al-Saedy, Muhannad A. E.; Harrity, Joseph P. A..

Direct introduction of a broad selection of aromatic, heteroaromatic, or alkyl fragments connected by a thioether group into these important heterocycles by using readily prepared thiosulfate salts was reported.

There are many compounds similar to this compound(4360-63-8)Synthetic Route of C4H7BrO2. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Safety of 2-Bromomethyl-1,3-dioxolane. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Bromomethyl-1,3-dioxolane, is researched, Molecular C4H7BrO2, CAS is 4360-63-8, about Discovery of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor: Scaffold hopping approach. Author is Ledneczki, Istvan; Tapolcsanyi, Pal; Gabor, Eszter; Visegrady, Andras; Vass, Marton; Eles, Janos; Holm, Patrik; Horvath, Anita; Pocsai, Aniko; Maho, Sandor; Greiner, Istvan; Kramos, Balazs; Beni, Zoltan; Koti, Janos; Kancz, Anna E.; Than, Marta; Kolok, Sandor; Laszy, Judit; Balazs, Ottilia; Bugovits, Gyula; Nagy, Jozsef; Vastag, Monika; Szajli, Agota; Bozo, Eva; Levay, Gyorgy; Lendvai, Balazs; Nemethy, Zsolt.

The paper focuses on the scaffold hopping-based discovery and characterization of novel nicotinic alpha 7 receptor pos. modulator (α7 nAChR PAM) ligands around the reference mol. (A-867744). First, substantial efforts were carried out to assess the importance of the various pharmacophoric elements on the in vitro potency (SAR evaluation) by chem. modifications. Subsequently, several new derivatives with versatile, heteroaromatic central cores were synthesized and characterized. A promising, pyrazole-containing new chemotype with good physicochem. and in vitro parameters was identified. Retrospective anal. based on homol. modeling was also carried out. Besides its favorable in vitro characteristics, the most advanced derivative 69 also showed in vivo efficacy in a rodent model of cognition (scopolamine-induced amnesia in the mouse place recognition test) and acceptable pharmacokinetic properties. Based on the in vivo data, the resulting mol. with advanced drug-like characteristics has the possibility to improve cognitive performance in a biol. relevant dose range, further strengthening the view of the supportive role of α7 nACh receptors in the cognitive processes.

There are many compounds similar to this compound(4360-63-8)Safety of 2-Bromomethyl-1,3-dioxolane. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Application In Synthesis of 2-Bromomethyl-1,3-dioxolane. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Bromomethyl-1,3-dioxolane, is researched, Molecular C4H7BrO2, CAS is 4360-63-8, about Assembly of multicyclic isoquinoline scaffolds from pyridines: formal total synthesis of fredericamycin A. Author is Wang, Fang-Xin; Yan, Jia-Lei; Liu, Zhixin; Zhu, Tingshun; Liu, Yingguo; Ren, Shi-Chao; Lv, Wen-Xin; Jin, Zhichao; Chi, Yonggui Robin.

The construction of an isoquinoline skeleton typically starts with benzene derivatives as substrates with the assistance of acids or transition metals. Disclosed here is a concise approach to prepare isoquinoline analogs by starting with pyridines to react with β-ethoxy α,β-unsaturated carbonyl compounds under basic conditions. Multiple substitution patterns and a relatively large number of functional groups (including those sensitive to acidic conditions) can be tolerated the method. In particular, protocol allows for efficient access to tricyclic isoquinolines found in hundreds of natural products with interesting bioactivities. The efficiency and operational simplicity of introducing structural complexity into the isoquinoline frameworks can likely enable the collective synthesis of a large set of natural products. Here show that fredericamycin A could be obtained via a short route by using isoquinoline synthesis as a key step.

There are many compounds similar to this compound(4360-63-8)Application In Synthesis of 2-Bromomethyl-1,3-dioxolane. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 4360-63-8, is researched, Molecular C4H7BrO2, about Assembly of multicyclic isoquinoline scaffolds from pyridines: formal total synthesis of fredericamycin A, the main research direction is multicyclic isoquinoline preparation; fredericamycin A total synthesis.Related Products of 4360-63-8.

The construction of an isoquinoline skeleton typically starts with benzene derivatives as substrates with the assistance of acids or transition metals. Disclosed here is a concise approach to prepare isoquinoline analogs by starting with pyridines to react with β-ethoxy α,β-unsaturated carbonyl compounds under basic conditions. Multiple substitution patterns and a relatively large number of functional groups (including those sensitive to acidic conditions) can be tolerated the method. In particular, protocol allows for efficient access to tricyclic isoquinolines found in hundreds of natural products with interesting bioactivities. The efficiency and operational simplicity of introducing structural complexity into the isoquinoline frameworks can likely enable the collective synthesis of a large set of natural products. Here show that fredericamycin A could be obtained via a short route by using isoquinoline synthesis as a key step.

There are many compounds similar to this compound(4360-63-8)Related Products of 4360-63-8. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Bromomethyl-1,3-dioxolane, is researched, Molecular C4H7BrO2, CAS is 4360-63-8, about Discovery of novel, potent, isosteviol-based antithrombotic agents.Formula: C4H7BrO2.

Thrombosis is a pathol. coagulation process and can lead to many serious thrombotic diseases. Here, we report a novel potent antithrombotic compound (6k) based on isosteviol with anticoagulant and antiplatelet activities. 6k selectively inhibited FXa (Ki = 0.015μM) against a panel of serine proteases and showed excellent anticoagulant activity (significant prolongation of ex vivo PT and aPTT over the vehicle, p < 0.01). 6k also significantly inhibited ADP-induced platelet aggregation in rats relative to the vehicle (p < 0.01). Furthermore, 6k exhibited potent ex vivo and in vivo antithrombotic activity in rats relative to the vehicle (p < 0.01 and p < 0.0001, resp.). Novel structure 6k, with potent antithrombotic activity, is expected to lead a promising approach for the development of antithrombotic agents. There are many compounds similar to this compound(4360-63-8)Formula: C4H7BrO2. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Optimization studies for hydrothermal gasification of partially burnt wood from forest fires for hydrogen-rich syngas production using Taguchi experimental design, published in 2021-08-15, which mentions a compound: 4360-63-8, mainly applied to hydrogen syngas hydrothermal gasification wood forest fire Taguchi method; Forest fire; Gasification; Hydrogen; Subcritical water; Supercritical water; Taguchi method, Formula: C4H7BrO2.

Forest fires significantly affect the wildlife, vegetation, composition and structure of the forests. This study explores the potential of partially burnt wood recovered in the aftermath of a recent Canadian forest fire incident as a feedstock for generating hydrogen-rich syngas through hydrothermal gasification. Partially burnt wood was gasified in hydrothermal conditions to study the influence of process temperature (300-500 °C), residence time (15-45 min), feed concentration (10-20 wt%) and biomass particle size (0.13 mm and 0.8 mm) using the statistical Taguchi method. Maximum hydrogen yield and total gas yield of 5.26 mmol/g and 11.88 mmol/g, resp. were obtained under optimized process conditions at 500 °C in 45 min with 10 wt% feed concentration using biomass particle size of 0.13 mm. The results from the mean of hydrogen yield show that the contribution of each exptl. factors was in the order of temperature > feed concentration > residence time > biomass particle size. Other gaseous products obtained at optimum conditions include CO2 (3.43 mmol/g), CH4 (3.13 mmol/g) and C2-C4 hydrocarbons (0.06 mmol/g).

There are many compounds similar to this compound(4360-63-8)Formula: C4H7BrO2. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Ledneczki, Istvan; Tapolcsanyi, Pal; Gabor, Eszter; Visegrady, Andras; Vass, Marton; Eles, Janos; Holm, Patrik; Horvath, Anita; Pocsai, Aniko; Maho, Sandor; Greiner, Istvan; Kramos, Balazs; Beni, Zoltan; Koti, Janos; Kancz, Anna E.; Than, Marta; Kolok, Sandor; Laszy, Judit; Balazs, Ottilia; Bugovits, Gyula; Nagy, Jozsef; Vastag, Monika; Szajli, Agota; Bozo, Eva; Levay, Gyorgy; Lendvai, Balazs; Nemethy, Zsolt researched the compound: 2-Bromomethyl-1,3-dioxolane( cas:4360-63-8 ).Reference of 2-Bromomethyl-1,3-dioxolane.They published the article 《Discovery of novel positive allosteric modulators of the α7 nicotinic acetylcholine receptor: Scaffold hopping approach》 about this compound( cas:4360-63-8 ) in European Journal of Medicinal Chemistry. Keywords: pos allosteric modulator nicotinic acetylcholine receptor drug discovery; Cognitive improvement; Nicotinic alpha 7 receptor; Positive allosteric modulator; Scaffold hopping; Structure activity relationship. We’ll tell you more about this compound (cas:4360-63-8).

The paper focuses on the scaffold hopping-based discovery and characterization of novel nicotinic alpha 7 receptor pos. modulator (α7 nAChR PAM) ligands around the reference mol. (A-867744). First, substantial efforts were carried out to assess the importance of the various pharmacophoric elements on the in vitro potency (SAR evaluation) by chem. modifications. Subsequently, several new derivatives with versatile, heteroaromatic central cores were synthesized and characterized. A promising, pyrazole-containing new chemotype with good physicochem. and in vitro parameters was identified. Retrospective anal. based on homol. modeling was also carried out. Besides its favorable in vitro characteristics, the most advanced derivative 69 also showed in vivo efficacy in a rodent model of cognition (scopolamine-induced amnesia in the mouse place recognition test) and acceptable pharmacokinetic properties. Based on the in vivo data, the resulting mol. with advanced drug-like characteristics has the possibility to improve cognitive performance in a biol. relevant dose range, further strengthening the view of the supportive role of α7 nACh receptors in the cognitive processes.

There are many compounds similar to this compound(4360-63-8)Reference of 2-Bromomethyl-1,3-dioxolane. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Photoredox asymmetric catalytic enantioconvergent substitution of 3-chlorooxindoles, published in 2019, which mentions a compound: 4360-63-8, Name is 2-Bromomethyl-1,3-dioxolane, Molecular C4H7BrO2, Synthetic Route of C4H7BrO2.

An enantioconvergent substitution of 3-substituted 3-chlorooxindoles I (R = H, 6-Cl, 4-Br, 5-NO2, etc.; R1 = 4-FC6H4S(O)2, Me; Ar = Ph, naphthalen-2-yl, C6D5, etc.) with N-aryl glycines Ar1NHCH2C(O)OH [Ar1 = 4-methoxyphenyl, 4-methoxy-3-(trifluoromethyl)phenyl] under visible light irradiation is reported. A transition-metal-free cooperative catalysis platform with a dicyanopyrazine-derived chromophore (DPZ) as a photoredox catalyst and a chiral Bronsted acid catalyst is effective for these transformations, which involve a single-electron transfer redox step and an enantioselective radical coupling. A variety of valuable chiral 3-aminomethylene-3-substituted oxindoles II can be directly synthesized with high yields and enantioselectivities.

There are many compounds similar to this compound(4360-63-8)Synthetic Route of C4H7BrO2. if you want to know more, you can check out my other articles. I hope it will help you，maybe you’ll find some useful information.

Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem