Category: 4360-63-8

Copper complexes bearing an NHC-calixarene unit: synthesis and application in click chemistry was written by Ourri, Benjamin;Tillement, Olivier;Tu, Tao;Jeanneau, Erwann;Darbost, Ulrich;Bonnamour, Isabelle. And the article was included in New Journal of Chemistry in 2016.Formula: C4H7BrO2 This article mentions the following:

The synthesis of N-heterocyclic carbene (NHC) copper complexes supported by calix[4]arene is reported. Mono-substituted calix[4]arene was prepared through conventional procedures, followed by the attachment of an imidazolyl group to create the precursor of NHC ligands. Alkylation with two alkyl bromides followed by metalation resulted in fully characterized original complexes. The x-ray structure showed an “out” conformation for copper. The catalytic activity of the complexes was studied in click chem., and revealed good performances. In particular, three new triazoles were synthesized in high yields, under solvent-free conditions and a fast reaction time. The newly synthesized chiral complex was tested in the kinetic resolution of racemic azide. In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8Formula: C4H7BrO2).

2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Formula: C4H7BrO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Second-generation lymphocyte function-associated antigen-1 inhibitors: 1H-imidazo[1,2-α]imidazol-2-one derivatives was written by Emeigh, Jonathan;Gao, Donghong A.;Goldberg, Daniel R.;Kuzmich, Daniel;Miao, Clara;Potocki, Ian;Qian, Kevin C.;Sorcek, Ronald J.;Jeanfavre, Deborah D.;Kishimoto, Kei;Mainolfi, Elizabeth A.;Nabozny, Gerald Jr.;Reilly, Patricia;Rothlein, Robert;Sellati, Rosemarie H.;Woska, Joseph R. Jr.;Chen, Shirlynn;Gunn, Jocelyn A.;O’Brien, Drane;Norris, Stephen H.;Kelly, Terence A.;Peng, Charline;Wu, Jiang-Ping. And the article was included in Journal of Medicinal Chemistry in 2004.Recommanded Product: 4360-63-8 This article mentions the following:

A novel class of lymphocyte function-associated antigen-1 (LFA-1) inhibitors is described. Discovered during the process to improve the physicochem. and metabolic properties of BIRT377, a previously reported hydantoin-based LFA-1 inhibitor, these compounds are 5- or 6-substituted derivatives of the 1H-imidazo[1,2-α]imidazol-2-one I. The structure-activity relationship (SAR) shows that electron-withdrawing groups at C(5) on the imidazole ring benefit potency and that oxygen-containing functional groups attached to a C(5)-sulfonyl or sulfonamide group further improve potency. This latter gain in potency is attributed to the interaction(s) of the functionalized sulfonyl/sulfonamide groups with the protein, likely polar-polar in nature, as suggested by SAR data. X-ray studies revealed that these bicyclic inhibitors bind to the I-domain of LFA-1 in a pattern similar to that of BIRT377. In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8Recommanded Product: 4360-63-8).

2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Recommanded Product: 4360-63-8

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Copper complexes bearing an NHC-calixarene unit: synthesis and application in click chemistry was written by Ourri, Benjamin;Tillement, Olivier;Tu, Tao;Jeanneau, Erwann;Darbost, Ulrich;Bonnamour, Isabelle. And the article was included in New Journal of Chemistry in 2016.Formula: C4H7BrO2 This article mentions the following:

The synthesis of N-heterocyclic carbene (NHC) copper complexes supported by calix[4]arene is reported. Mono-substituted calix[4]arene was prepared through conventional procedures, followed by the attachment of an imidazolyl group to create the precursor of NHC ligands. Alkylation with two alkyl bromides followed by metalation resulted in fully characterized original complexes. The x-ray structure showed an “out” conformation for copper. The catalytic activity of the complexes was studied in click chem., and revealed good performances. In particular, three new triazoles were synthesized in high yields, under solvent-free conditions and a fast reaction time. The newly synthesized chiral complex was tested in the kinetic resolution of racemic azide. In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8Formula: C4H7BrO2).

2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Formula: C4H7BrO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Second-generation lymphocyte function-associated antigen-1 inhibitors: 1H-imidazo[1,2-α]imidazol-2-one derivatives was written by Emeigh, Jonathan;Gao, Donghong A.;Goldberg, Daniel R.;Kuzmich, Daniel;Miao, Clara;Potocki, Ian;Qian, Kevin C.;Sorcek, Ronald J.;Jeanfavre, Deborah D.;Kishimoto, Kei;Mainolfi, Elizabeth A.;Nabozny, Gerald Jr.;Reilly, Patricia;Rothlein, Robert;Sellati, Rosemarie H.;Woska, Joseph R. Jr.;Chen, Shirlynn;Gunn, Jocelyn A.;O’Brien, Drane;Norris, Stephen H.;Kelly, Terence A.;Peng, Charline;Wu, Jiang-Ping. And the article was included in Journal of Medicinal Chemistry in 2004.Recommanded Product: 4360-63-8 This article mentions the following:

A novel class of lymphocyte function-associated antigen-1 (LFA-1) inhibitors is described. Discovered during the process to improve the physicochem. and metabolic properties of BIRT377, a previously reported hydantoin-based LFA-1 inhibitor, these compounds are 5- or 6-substituted derivatives of the 1H-imidazo[1,2-α]imidazol-2-one I. The structure-activity relationship (SAR) shows that electron-withdrawing groups at C(5) on the imidazole ring benefit potency and that oxygen-containing functional groups attached to a C(5)-sulfonyl or sulfonamide group further improve potency. This latter gain in potency is attributed to the interaction(s) of the functionalized sulfonyl/sulfonamide groups with the protein, likely polar-polar in nature, as suggested by SAR data. X-ray studies revealed that these bicyclic inhibitors bind to the I-domain of LFA-1 in a pattern similar to that of BIRT377. In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8Recommanded Product: 4360-63-8).

2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Recommanded Product: 4360-63-8

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Sulfite-Induced N-Alkylation and Thioketonization of Azoles Enable Access to Diverse Azole Thiones was written by Deng, Jian-Chao;Chen, Jia-Hao;Zhang, Jun-Rong;Lu, Ting-Ting;Tang, Ri-Yuan. And the article was included in Advanced Synthesis & Catalysis in 2018.Application of 4360-63-8 This article mentions the following:

The direct modification of azole skeletons enables access to drug-like mols. The development of a highly compatible reaction platform for this pursuit still remains challenging. Herein, we report the use of sulfite as the single electron transfer (SET) reducing agent for the activation of functionalized bromoalkanes, elemental sulfur, and imidazoliniums for the transition metal-free and base-free N-alkylation and thioketonization of azoles. Excellent functional group tolerance and high synthetic efficiency proved particularly advantageous for the rapid assembly of a large array of pharmaceutically-oriented azole thiones , e.g., I, many of which contain synthetically and biol. useful functional groups. The direct transformation of drug mols. (such as Ketoconazole, Econazole, and Fluconazole) into their corresponding azole thiones has also been successfully achieved. Reactions with selenium also proceeded smoothly under the optimized conditions. Successful gram-scale reactions demonstrate the good applicability of this methodol. In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8Application of 4360-63-8).

2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Application of 4360-63-8

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Copper complexes bearing an NHC-calixarene unit: synthesis and application in click chemistry was written by Ourri, Benjamin;Tillement, Olivier;Tu, Tao;Jeanneau, Erwann;Darbost, Ulrich;Bonnamour, Isabelle. And the article was included in New Journal of Chemistry in 2016.Formula: C4H7BrO2 This article mentions the following:

The synthesis of N-heterocyclic carbene (NHC) copper complexes supported by calix[4]arene is reported. Mono-substituted calix[4]arene was prepared through conventional procedures, followed by the attachment of an imidazolyl group to create the precursor of NHC ligands. Alkylation with two alkyl bromides followed by metalation resulted in fully characterized original complexes. The x-ray structure showed an “out” conformation for copper. The catalytic activity of the complexes was studied in click chem., and revealed good performances. In particular, three new triazoles were synthesized in high yields, under solvent-free conditions and a fast reaction time. The newly synthesized chiral complex was tested in the kinetic resolution of racemic azide. In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8Formula: C4H7BrO2).

2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Formula: C4H7BrO2

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Second-generation lymphocyte function-associated antigen-1 inhibitors: 1H-imidazo[1,2-α]imidazol-2-one derivatives was written by Emeigh, Jonathan;Gao, Donghong A.;Goldberg, Daniel R.;Kuzmich, Daniel;Miao, Clara;Potocki, Ian;Qian, Kevin C.;Sorcek, Ronald J.;Jeanfavre, Deborah D.;Kishimoto, Kei;Mainolfi, Elizabeth A.;Nabozny, Gerald Jr.;Reilly, Patricia;Rothlein, Robert;Sellati, Rosemarie H.;Woska, Joseph R. Jr.;Chen, Shirlynn;Gunn, Jocelyn A.;O’Brien, Drane;Norris, Stephen H.;Kelly, Terence A.;Peng, Charline;Wu, Jiang-Ping. And the article was included in Journal of Medicinal Chemistry in 2004.Recommanded Product: 4360-63-8 This article mentions the following:

A novel class of lymphocyte function-associated antigen-1 (LFA-1) inhibitors is described. Discovered during the process to improve the physicochem. and metabolic properties of BIRT377, a previously reported hydantoin-based LFA-1 inhibitor, these compounds are 5- or 6-substituted derivatives of the 1H-imidazo[1,2-α]imidazol-2-one I. The structure-activity relationship (SAR) shows that electron-withdrawing groups at C(5) on the imidazole ring benefit potency and that oxygen-containing functional groups attached to a C(5)-sulfonyl or sulfonamide group further improve potency. This latter gain in potency is attributed to the interaction(s) of the functionalized sulfonyl/sulfonamide groups with the protein, likely polar-polar in nature, as suggested by SAR data. X-ray studies revealed that these bicyclic inhibitors bind to the I-domain of LFA-1 in a pattern similar to that of BIRT377. In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8Recommanded Product: 4360-63-8).

2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Recommanded Product: 4360-63-8

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

1,2,4-Benzothiadiazine derivatives as α₁ and 5-HT_1A receptor ligands was written by Tait, Annalisa;Luppi, Amedeo;Franchini, Silvia;Preziosi, Elisa;Parenti, Carlo;Buccioni, Michela;Marucci, Gabriella;Leonardi, Amedeo;Poggesi, Elena;Brasili, Livio. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Reference of 4360-63-8 This article mentions the following:

A series of 1,2,4-benzothiadiazine derivatives I (R = H, Me, Cl) and II with an arylpiperazine moiety linked at position 3 of the heterocyclic ring were synthesized and assessed for their pharmacol. profiles at α₁-adrenoceptor subtypes (α_1A, α_1B and α_1D) by functional experiments and by in vitro binding studies at human cloned 5-HT_1A receptor. I (R = H) was identified as a α_1D antagonist (pK_bα_1D = 7.59; α_1D/α_1A > 389; α_1D/α_1B = 135) with high selectivity over 5-HT_1A receptor (5-HT_1A/α_1D < 0.01), while II (R = Cl) was characterized as a 5-HT_1A receptor ligand, highly selective over α_1D-adrenoceptor subtype (pK_i5-HT_1A = 8.04; 5-HT_1A/α_1D = 1096). Further pharmacol. studies demonstrated that II (R = Cl) was a partial agonist at 5-HT_1A receptor (E_max = 23, pD₂ = 6.92). In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8Reference of 4360-63-8).

2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Reference of 4360-63-8

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Zn/CuI-Mediated Coupling of Alkyl Halides with Vinyl Sulfones, Vinyl Sulfonates, and Vinyl Sulfonamides was written by Zhao, Matthew M.;Qu, Chuanxing;Lynch, Joseph E.. And the article was included in Journal of Organic Chemistry in 2005.Category: dioxole This article mentions the following:

A novel high-yielding Zn/CuI-mediated coupling of alkyl halides with vinyl sulfones, vinyl sulfonates, and vinyl sulfonamides is described. This protocol is applicable for primary, secondary, and tertiary alkyl iodides and bromides. Alkyl chlorides and aryl and vinyl halides were unreactive under the reaction conditions. Formamide was found to be a superior solvent for obtaining high yields. In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8Category: dioxole).

2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Cascade radical reaction of substrates with a carbon-carbon triple bond as a radical acceptor was written by Miyabe, Hideto;Asada, Ryuta;Takemoto, Yoshiji. And the article was included in Beilstein Journal of Organic Chemistry in 2013.Quality Control of 2-Bromomethyl-1,3-dioxolane This article mentions the following:

The limitation of hydroxamate ester as a chiral Lewis acid coordination moiety was demonstrated in an intermol. reaction involving a radical addition and sequential allylation processes. Next, the effect of hydroxamate ester was studied in the cascade addition-cyclization-trapping reaction of substrates with a carbon-carbon triple bond as a radical acceptor. When substrates with a methacryloyl moiety and a carbon-carbon triple bond as two polarity-different radical acceptors were employed, the cascade reaction proceeded effectively. A high level of enantioselectivity was also obtained by a proper combination of chiral Lewis acid and these substrates. In the experiment, the researchers used many compounds, for example, 2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8Quality Control of 2-Bromomethyl-1,3-dioxolane).

2-Bromomethyl-1,3-dioxolane (cas: 4360-63-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Quality Control of 2-Bromomethyl-1,3-dioxolane

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem