Category: 25150-27-0

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 6,7-Dichlorobenzo[d]thiazol-2-amine, is researched, Molecular C7H4Cl2N2S, CAS is 25150-27-0, about 5,6-(6,7-)dichlorobenzothiazolylazo dyes for synthetic polymer fibers, the main research direction is chlorobenzothiazole azo dye polyester.Product Details of 25150-27-0.

The synthesis and properties of a series of monoazo dyes derived from an isomer mixture of 5,6-dichloro- and 6,7-dichloro-2-aminobenzothiazoles as the diazo component are reported. By appropriate selection of substituents in the coupling component, dyes varying in hue from orange-red to deep violet can be obtained. Coloration and light-fastness evaluations of the dyes on polyester fiber indicate that they can be viable alternatives to anthraquinone-based dyes of similar hue.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Alaimo, Robert J.; Pelosi, Stanford S.; Hatton, Christopher J.; Gray, Joseph E. published the article 《Antiparasitic thiocyanatobenzothiazoles》. Keywords: anthelmintic fungicide thiocyanatobenzothiazole; benzothiazole thiocyanato yeast antiparasitic.They researched the compound: 6,7-Dichlorobenzo[d]thiazol-2-amine( cas:25150-27-0 ).Reference of 6,7-Dichlorobenzo[d]thiazol-2-amine. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:25150-27-0) here.

A series of 7 title compound was prepared by the reaction of the appropriate aniline derivative with thiocyanogen [505-14-6] generated in situ followed by thermal cyclization. The activity of 2-amino-6-ethyl-4-thiocyanatobenzothiazole (I) [37069-20-8] against Ascaris suum and Hymenolepis nana in mice was comparable to that of dl-tetramisole [5036-02-2] and bunamidine [3748-77-4], resp. 2-Amino-7-chloro-6-fluoro-4-thiocyanatobenzothiazole (II) [37525-33-0] and 2-amino-6,7-dichloro-4-thiocyanatobenzothiazole (III) [37069-18-4] were active in vitro against several yeast species, including Candida albicans and Microsporum canis.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Quality Control of 6,7-Dichlorobenzo[d]thiazol-2-amine. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 6,7-Dichlorobenzo[d]thiazol-2-amine, is researched, Molecular C7H4Cl2N2S, CAS is 25150-27-0, about Identification of a novel series of tetrahydrodibenzazocines as inhibitors of 17β-hydroxysteroid dehydrogenase type 3. Author is Fink, Brian E.; Gavai, Ashvinikumar V.; Tokarski, John S.; Goyal, Bindu; Misra, Raj; Xiao, Hai-Yun; Kimball, S. David; Han, Wen-Ching; Norris, Derek; Spires, Thomas E.; You, Dan; Gottardis, Marco M.; Lorenzi, Matthew V.; Vite, Gregory D..

A novel series of 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitors has been identified. These inhibitors, based on a dibenzazocine core, exhibited picomolar to low nanomolar inhibition of 17β-HSD3 in cell-free enzymic as well as in cell-based transcriptional reporter assays.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Journal of Medicinal Chemistry called Antiparasitic thiocyanatobenzothiazoles, Author is Alaimo, Robert J.; Pelosi, Stanford S.; Hatton, Christopher J.; Gray, Joseph E., which mentions a compound: 25150-27-0, SMILESS is NC1=NC2=CC=C(Cl)C(Cl)=C2S1, Molecular C7H4Cl2N2S, Electric Literature of C7H4Cl2N2S.

A series of 7 title compound was prepared by the reaction of the appropriate aniline derivative with thiocyanogen [505-14-6] generated in situ followed by thermal cyclization. The activity of 2-amino-6-ethyl-4-thiocyanatobenzothiazole (I) [37069-20-8] against Ascaris suum and Hymenolepis nana in mice was comparable to that of dl-tetramisole [5036-02-2] and bunamidine [3748-77-4], resp. 2-Amino-7-chloro-6-fluoro-4-thiocyanatobenzothiazole (II) [37525-33-0] and 2-amino-6,7-dichloro-4-thiocyanatobenzothiazole (III) [37069-18-4] were active in vitro against several yeast species, including Candida albicans and Microsporum canis.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

COA of Formula: C7H4Cl2N2S. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 6,7-Dichlorobenzo[d]thiazol-2-amine, is researched, Molecular C7H4Cl2N2S, CAS is 25150-27-0, about Synthesis, characterization and biological activity of 5-arylidene-3-(6,7-dichloro-1,3-benzothiazol-2-yl)-phenyl-3,5-dihydro-4H-imidazol-4-ones. Author is Baldaniya, B. B..

Some novel 5-arylidene-3-(6,7-dichloro-1,3-benzothiazol-2-yl)-2-phenyl-3,5-dihydro-4H-imidazol-4-ones were synthesized and characterized by elemental analyses, IR, NMR, and mass spectra. The products were evaluated for antibacterial and antifungal activities against different strains of bacteria and fungi.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

SDS of cas: 25150-27-0. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 6,7-Dichlorobenzo[d]thiazol-2-amine, is researched, Molecular C7H4Cl2N2S, CAS is 25150-27-0, about Synthesis of some 4H-pyrimido[2,1-b]benzothiazol-4-ones.

A series of 8-substituted and 7,8-disubstituted-4-oxo-3-(4H-pyrimido[2,1-b]benzothiazole)carboxylic acids (I) and esters including a 9-aza analog were synthesized from substituted 2-aminobenzothiazoles and di-Et ethoxymethylenemalonate. No significant antiparasitic activity was detected.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Preparation and characterization of 2-amino-5,6-dichloro- and 2-amino-6,7-dichlorobenzothiazole, published in 1971, which mentions a compound: 25150-27-0, mainly applied to benzothiazoles amino via anilines; amino chloro benzothiazoles separation; anilines thiocyanation benzothiazoles, Quality Control of 6,7-Dichlorobenzo[d]thiazol-2-amine.

A mixture of 2-amino-5,6-dichlorobenzothiazole (I) and 2-amino-6,7-dichlorobenzothiazole (II) is prepared by the reaction of 3,4-dichloroaniline (III) with thiocyanogen. 2-Amino-4,5-dichlorophenyl thiocyanate and 6-amino-2,3-dichlorophenyl thiocyanate are the intermediates of I and II. Thus, III is treated with KSCN, thiocyanogen is formed by the addition of Br, and the I-II mixture obtained is separated via HCl salt formation. NMR spectra are given.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Application of 25150-27-0. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 6,7-Dichlorobenzo[d]thiazol-2-amine, is researched, Molecular C7H4Cl2N2S, CAS is 25150-27-0, about Hetarylazo disperse dyes derived from 5,6-dichloro- and 6,7-dichloro-2-aminobenzothiazoles. Author is Peters, A. T.; Tsatsaroni, E.; Ma, Xisai.

The isomer mixtures resulting from the diazotization of 5,6-(6,7-)dichloro-2-aminobenzothiazole and coupling to N-substituted anilines were separable by column chromatog. Isomer characterization was effected by unambiguous dye synthesis from the individual dichloro-2-aminobenzothiazoles, and by 1H NMR. The color and dyeing parameters of the isomers on polyester were essentially equivalent, and similar to those of the corresponding isomer mixtures

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Product Details of 25150-27-0. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 6,7-Dichlorobenzo[d]thiazol-2-amine, is researched, Molecular C7H4Cl2N2S, CAS is 25150-27-0, about Synthesis and Antibacterial Activity of a Novel Series of 2,3-Diaryl-substituted-imidazo(2,1-b)-benzothiazole Derivatives. Author is Palkar, Mahesh; Noolvi, Malleshappa; Sankangoud, Ramappa; Maddi, Veeresh; Gadad, Andanappa; Nargund, Laxmi Venkat G..

Benzothiazole and imidazole compounds are extensively studied heterocyclics due to their wide spectrum of bioactivities. Among them, the imidazo(2,1-b)-benzothiazole derivatives are pharmacol. important because of their immunostimulant, anti-inflammatory, antifungal, antimicrobial, antitumor, and other activities. In the present research work, a novel series of 2,3-diaryl-substituted imidazo(2,1-b)-benzothiazoles 13a-o have been synthesized by reaction of substituted 2-aminobenzothiazoles 1-8 and an appropriately substituted α-bromo-1-(4”-substituted)-phenyl-2-(4′-substituted)-phenyl-1-ethanones 9-12 in the presence of anhydrous acetonitrile. They were characterized by physicochem., elemental, and spectral (IR, 1H-NMR, and Mass) data. All the synthesized compounds were screened for their in-vitro antibacterial activity against Gram-pos., Gram-neg. bacteria. The investigation of antibacterial screening data revealed that most of the compounds tested have demonstrated congruent activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Pseudomonas aeruginosa as compared with the standard ampicillin. Among the series, compounds 13d, 13h, and 13m exhibited excellent an antibacterial activity profile as compared with the standard In summary, preliminary results indicate that some of the newly synthesized title compounds exhibited promising antibacterial activities and they warrant more consideration as prospective antimicrobials.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Alaimo, Robert J. researched the compound: 6,7-Dichlorobenzo[d]thiazol-2-amine( cas:25150-27-0 ).Recommanded Product: 6,7-Dichlorobenzo[d]thiazol-2-amine.They published the article 《Preparation and characterization of 2-amino-5,6-dichloro- and 2-amino-6,7-dichlorobenzothiazole》 about this compound( cas:25150-27-0 ) in Journal of Heterocyclic Chemistry. Keywords: benzothiazoles amino via anilines; amino chloro benzothiazoles separation; anilines thiocyanation benzothiazoles. We’ll tell you more about this compound (cas:25150-27-0).

A mixture of 2-amino-5,6-dichlorobenzothiazole (I) and 2-amino-6,7-dichlorobenzothiazole (II) is prepared by the reaction of 3,4-dichloroaniline (III) with thiocyanogen. 2-Amino-4,5-dichlorophenyl thiocyanate and 6-amino-2,3-dichlorophenyl thiocyanate are the intermediates of I and II. Thus, III is treated with KSCN, thiocyanogen is formed by the addition of Br, and the I-II mixture obtained is separated via HCl salt formation. NMR spectra are given.

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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem