Category: 177-10-6

Deng, Gui-sheng published the artcileAcetalization of carbonyl compounds with diols catalyzed by InCl₃.4H₂O, Formula: C8H14O2, the publication is Hunan Shifan Daxue Ziran Kexue Xuebao (2012), 35(4), 35-39, database is CAplus.

Acetalization of aromatic and aliphatic aldehydes with diols catalyzed by InCl₃.4H₂O was carried out in refluxing benzene to give the corresponding acetals in 76%-85% yields. And ketone acetals were obtained in 75%-82% yields in the same method.

Hunan Shifan Daxue Ziran Kexue Xuebao published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Formula: C8H14O2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Teng, Jun-jiang published the artcileCatalytic synthesis of cyclohexanone ethylene ketal by polyaniline doped with sodium hydrogen sulfate, Quality Control of 177-10-6, the publication is Riyong Huaxue Gongye (2012), 42(3), 209-212, database is CAplus.

Cyclohexanone ethylene ketal was synthesized from cyclohexanone and ethylene glycol as starting materials using polyaniline (PAn) doped with 20% (mass fraction) of sodium hydrogen sulfate (PAn-NaHSO₄) as catalyst. Catalytic activity of PAn-NaHSO₄ was investigated. Effect of factors such as mole ratio of ethylene glycol to cyclohexanone, dosage of the catalyst, reaction time, dosage of water stripping agent on product yield were examined systematically and optimum reaction conditions were identified by orthogonal designed experiment Under optimal conditions: based on amount of cyclohexanone 0.1 mol, mole ratio n(ethylene glycol): n(cyclohexanone) = 1.6:1, mass fraction of PAn-NaHSO₄ 1.2% of the total reactants, water stripping agent cyclohexane 9 mL and reaction time 2.5 h, yield of the product achieves 96.79%. The product was identified as cyclohexanone ethylene ketal by IR and GC-MS. Purity of product achieves 99.0%. After reusing the catalyst for 5 times, yield of the product is still higher than 90.0%.

Riyong Huaxue Gongye published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C17H14N2O2, Quality Control of 177-10-6.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Farkas, Roland published the artcileSynthesis of 2-(1,4-dioxaspiro[4.5]decan-6-yl)acrylamides from 2-acetylcyclohexanone via palladium-catalysed aminocarbonylation, Quality Control of 177-10-6, the publication is Monatshefte fuer Chemie (2015), 146(10), 1665-1671, database is CAplus.

6-(1-Iodovinyl)-1,4-dioxaspiro[4.5]decane, an iodoalkene obtained from 2-acetylcyclohexanone via ethylene ketal formation, hydrazone formation and iodination, was aminocarbonylated in the presence of a palladium-phosphine precatalyst. Systematic investigations revealed that 2-(1,4-dioxaspiro[4.5]decan-6-yl)acrylamides I [R¹ = H; R² = tBu, CH₂CO₂Me, CH(CH₃)CO₂Me, CH{CH(CH₃)₂}CO₂Me; R¹R² = (CH₂)₅, (CH₂)O(CH₂)₂, CH(CO₂Me)(CH₂)₃] can be obtained in high yields via palladium-catalyzed aminocarbonylation. The influence of the amine nucleophiles and of the reaction conditions on the isolated yields was investigated.

Monatshefte fuer Chemie published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Quality Control of 177-10-6.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Hu, Jing published the artcileLeather odor analysis by GC-MS and simulation, HPLC of Formula: 177-10-6, the publication is Zhongguo Pige (2012), 41(5), 28-31, database is CAplus.

The volatile organic components of different leathers were extracted by Soxhlet extraction and determined with gas chromatog. and mass spectrometry (GC-MS). The leather fragrance was simulated by the sensor anal. based on the GC-MS results. The results show that there are many volatile organic components in the odor of the unfinished and finished sheep garment leathers, cow garment leather and cow car seat leather. These components are hydrocarbons, esters, aldehydes, acids, ethers and ketones, etc. Based on the GC-MS results, the leather fragrance is further prepared

Zhongguo Pige published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, HPLC of Formula: 177-10-6.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Sun, Xudong published the artcileSynthesis of a novel multi-SO₃H functionalized ionic liquid and its catalytic activities, Application of 1,4-Dioxaspiro[4.5]decane, the publication is Kinetics and Catalysis (2012), 53(3), 301-305, database is CAplus.

A novel multi-SO₃H functionalized ionic liquid is synthesized and a detailed account of its catalytic activities in acetalization and acetylation is given. The results showed that the ionic liquid is very efficient in the conventional acid-catalyzed reactions with good to excellent yields within a short reaction time. Operational simplicity, small amounts required, low cost of the catalyst, high yields, scalability and reusability are the key features of this methodol., which indicates the high potentialities of the novel ionic liquid to be used in environmentally friendly processes.

Kinetics and Catalysis published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C7H5BF4O3, Application of 1,4-Dioxaspiro[4.5]decane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Jiang, Dabo published the artcileSynthesis of acetals (ketals) catalyzed by phosphogypsum, COA of Formula: C8H14O2, the publication is Shiyou Huagong (2016), 45(3), 330-334, database is CAplus.

The synthesis of acetals (ketones) catalyzed by phosphogypsum (PG) was explored. The effects of the mole ratio of ethylene glycol to cyclohexanone, catalyst dosage, reaction time, water-carrying agents, cyclohexane dosage and catalyst reuse times on the yields of cyclohexanone glycol ketal were investigated. The results showed that the yield of cyclohexanone glycol ketal reached 99.9% under the conditions of catalyst dosage 7.5% (w), mole ratio of ethylene glycol to cyclohexanone 1.5, cyclohexane 16 mL and reaction time 2.5 h. After PG was reused 8 times, the yield of cyclohexanone glycol ketal still reached 98.5%. The catalytic activities of PG in the syntheses of 12 acetals (ketones) were studied. PG indicated excellent catalytic performances for the synthesis of the 12 acetals (ketones) and was a environmentally friendly solid acid catalyst for the utilization of the byproduct PG from phosphate industry.

Shiyou Huagong published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, COA of Formula: C8H14O2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

He, Si-Qing published the artcilePreparation of carboxyethyltin group-functionalized highly ordered mesoporous organosilica composite material with double acid sites, Name: 1,4-Dioxaspiro[4.5]decane, the publication is Journal of Materials Science (2019), 54(6), 4601-4618, database is CAplus.

A series of highly ordered mesoporous ethane-bridged organosilica composite materials functionalized by carboxyethyltin group, SnR-Si(Et)Si-X (SnR and Si(Et)Si denote [Sn(CH₂)₂COOH]³⁺ and ethane-bridged organosilica groups, resp.), were successfully designed through one-step co-condensation-hydrothermal method. The pore morphol. and textural properties, Sn(IV) coordination environment, the type of acid site, Bronsted and Lewis acid strength were systematically characterized by LXRD, TEM observation, N₂ porosimetry measurements, MAS NMR (²⁹Si, ¹³C, ¹¹⁹Sn), UV-Vis diffuse reflectance spectrum, as well as ¹H and ³¹P MAS NMR, FT-IR anal. of adsorbed pyridine, acid-base titration Composite materials SnR-Si(Et)Si-X possess Bronsted and Lewis acid sites, which originates from -COOH in [Sn(CH₂)₂COOH]³⁺ group and bridging OH in [Si(OH)SnR] group as well as tetrahedral coordination framework Sn(IV) in the open configuration [SnR(SiO)₃(OH)], resp. The above 2D hexagonal mesoporous structure with unique textural properties, double acid sites (Bronsted and Lewis acid sites) and hydrophobic surface make SnR-Si(Et)Si-X exhibit excellent acid catalytic activity, reusability and water tolerance toward ketalization of cyclohexanone with glycol in absence of azeotrope agent at low temperature

Journal of Materials Science published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Name: 1,4-Dioxaspiro[4.5]decane.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Ovsyannikova, M. N. published the artcileAntibacterial activity of substituted 1,3-dioxolanes, Computed Properties of 177-10-6, the publication is Pharmaceutical Chemistry Journal (2013), 47(3), 142-145, database is CAplus.

Cyclic ketals and acetals (1,3-dioxolanes) substituted at positions 2 and 4 of the dioxolane ring, prepared by condensation of glycerol and ethylene glycol with aldehydes and ketones, exhibited antimicrobial activity against Gram-pos. and Gram-neg. bacteria. This activity, which may be associated with the antiradical activity of the compounds and depended on their hydrophilic-hydrophobic balance, allows targeted variation in structural parameters for the creation of new active compounds Cyclic ketals with high antimicrobial activity can be used as antiseptics for sterilization of working surfaces and instruments.

Pharmaceutical Chemistry Journal published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, Computed Properties of 177-10-6.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Varfolomeev, S. D. published the artcileNew possibilities in the synthesis of fuel oxygenates from renewable sources, Synthetic Route of 177-10-6, the publication is Russian Chemical Bulletin (2019), 68(4), 717-724, database is CAplus.

A general problem in the production of the main types of liquid biofuel, bioethanol and biodiesel, is that renewable resources are not utilized completely. These are ballast polyols: hemicellulose or its structural units, pentaat. monosaccharides (xylose and arabinose), and biodiesel glycerol. The problem of utilization of these compounds by transforming them into a hydrophobized fuel form by the conversion to cyclic ketals (CK) during condensation with lower carbonyl compounds is reviewed. The CK-ethanol pair significantly increases the octane number and provides phase stability of fuel compositions The ability of CK to inhibit radical processes responsible for fuel characteristics was studied in model reactions with Ph radicals and at. chlorine. The carbon-centered radicals formed in protic media are transformed into more stable cyclic radical cations. Alternative methods of processing natural raw materials using biocatalysis and supercritical fluid technologies are analyzed.

Russian Chemical Bulletin published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C10H12F6N4O6PdS2, Synthetic Route of 177-10-6.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem

Brockway, Anthony J. published the artcileSynthesis and evaluation of analogs of 5′-(((Z)-4-amino-2-butenyl)methylamino)-5′-deoxyadenosine (MDL 73811, or AbeAdo) – An inhibitor of S-adenosylmethionine decarboxylase with antitrypanosomal activity, COA of Formula: C8H14O2, the publication is Bioorganic & Medicinal Chemistry (2017), 25(20), 5433-5440, database is CAplus and MEDLINE.

We describe our efforts to improve the pharmacokinetic properties of a mechanism-based suicide inhibitor of the polyamine biosynthetic enzyme S-adenosylmethionine decarboxylase (AdoMetDC), essential for the survival of the eukaryotic parasite Trypanosoma brucei responsible for Human African Trypanosomiasis (HAT). The lead compound, 5′-(((Z)-4-amino-2-butenyl)methylamino)-5′-deoxyadenosine (1, also known as MDL 73811, or AbeAdo), has curative efficacy at a low dosage in a hemolymphatic model of HAT but displayed no demonstrable effect in a mouse model of the CNS stage of HAT due to poor blood-brain barrier permeation. Therefore, we prepared and evaluated an extensive set of analogs with modifications in the aminobutenyl side chain, the 5′-amine, the ribose, and the purine fragments. Although we gained valuable structure-activity insights from this comprehensive dataset, we did not gain traction on improving the prospects for CNS penetration while retaining the potent antiparasitic activity and metabolic stability of the lead compound 1.

Bioorganic & Medicinal Chemistry published new progress about 177-10-6. 177-10-6 belongs to dioxole, auxiliary class Dioxolane,Spiro, name is 1,4-Dioxaspiro[4.5]decane, and the molecular formula is C8H14O2, COA of Formula: C8H14O2.

Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem