Category: 15186-48-8

Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae – Identification of LYS228 was written by Reck, Folkert;Bermingham, Alun;Blais, Johanne;Capka, Vladimir;Cariaga, Taryn;Casarez, Anthony;Colvin, Richard;Dean, Charles R.;Fekete, Alex;Gong, Wanben;Growcott, Ellie;Guo, Hongqiu;Jones, Adriana K.;Li, Cindy;Li, Fengxia;Lin, Xiaodong;Lindvall, Mika;Lopez, Sara;McKenney, David;Metzger, Louis;Moser, Heinz E.;Prathapam, Ramadevi;Rasper, Dita;Rudewicz, Patrick;Sethuraman, Vijay;Shen, Xiaoyu;Shaul, Jacob;Simmons, Robert L.;Tashiro, Kyuto;Tang, Dazhi;Tjandra, Meiliana;Turner, Nancy;Uehara, Tsuyoshi;Vitt, Charles;Whitebread, Steven;Yifru, Aregahegn;Zang, Xu;Zhu, Qingming. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2018.SDS of cas: 15186-48-8 This article mentions the following:

Metallo-β-lactamases (MBLs), such as New Delhi metallo-β-lactamase (NDM-1) have spread world-wide and present a serious threat. Expression of MBLs confers resistance in Gram-neg. bacteria to all classes of β-lactam antibiotics, with the exception of monobactams, which are intrinsically stable to MBLs. However, existing first generation monobactam drugs like aztreonam have limited clin. utility against MBL-expressing strains because they are impacted by serine β-lactamases (SBLs), which are often co-expressed in clin. isolates. Here, we optimized novel monobactams for stability against SBLs, which led to the identification of LYS228 (compound 31). LYS228 is potent in the presence of all classes of β-lactamases and shows potent activity against carbapenem-resistant isolates of Enterobacteriaceae (CRE). In the experiment, the researchers used many compounds, for example, (R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8SDS of cas: 15186-48-8).

(R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.SDS of cas: 15186-48-8

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae – Identification of LYS228 was written by Reck, Folkert;Bermingham, Alun;Blais, Johanne;Capka, Vladimir;Cariaga, Taryn;Casarez, Anthony;Colvin, Richard;Dean, Charles R.;Fekete, Alex;Gong, Wanben;Growcott, Ellie;Guo, Hongqiu;Jones, Adriana K.;Li, Cindy;Li, Fengxia;Lin, Xiaodong;Lindvall, Mika;Lopez, Sara;McKenney, David;Metzger, Louis;Moser, Heinz E.;Prathapam, Ramadevi;Rasper, Dita;Rudewicz, Patrick;Sethuraman, Vijay;Shen, Xiaoyu;Shaul, Jacob;Simmons, Robert L.;Tashiro, Kyuto;Tang, Dazhi;Tjandra, Meiliana;Turner, Nancy;Uehara, Tsuyoshi;Vitt, Charles;Whitebread, Steven;Yifru, Aregahegn;Zang, Xu;Zhu, Qingming. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2018.SDS of cas: 15186-48-8 This article mentions the following:

Metallo-β-lactamases (MBLs), such as New Delhi metallo-β-lactamase (NDM-1) have spread world-wide and present a serious threat. Expression of MBLs confers resistance in Gram-neg. bacteria to all classes of β-lactam antibiotics, with the exception of monobactams, which are intrinsically stable to MBLs. However, existing first generation monobactam drugs like aztreonam have limited clin. utility against MBL-expressing strains because they are impacted by serine β-lactamases (SBLs), which are often co-expressed in clin. isolates. Here, we optimized novel monobactams for stability against SBLs, which led to the identification of LYS228 (compound 31). LYS228 is potent in the presence of all classes of β-lactamases and shows potent activity against carbapenem-resistant isolates of Enterobacteriaceae (CRE). In the experiment, the researchers used many compounds, for example, (R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8SDS of cas: 15186-48-8).

(R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.SDS of cas: 15186-48-8

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

A nitrilase-mediated entry to 4-carboxymethyl-β-lactams from chemically prepared 4-(cyanomethyl)azetidin-2-ones was written by Decuyper, Lena;Piens, Nicola;Mincke, Jens;Bomon, Jeroen;De Schrijver, Bert;Mollet, Karen;De Winter, Karel;Desmet, Tom;D’hooghe, Matthias. And the article was included in RSC Advances in 2016.Computed Properties of C6H10O3 This article mentions the following:

The compounds (3R,4S)-3-Alkoxy/aryloxy-4-(cyanomethyl)azetidin-2-ones I (R¹ = i-Pr, n-Bu; R² = Me, Bn, Ph; R³ = CN) were efficiently prepared from readily available 1,2:5,6-di-O-isopropylidene-D-mannitol by means of a classical organic synthesis approach via 4-hydroxymethyl-β-lactams I (R³ = OH) as key intermediates. The corresponding 4-carboxymethyl-β-lactams I (R³ = CO₂H) were subsequently obtained after selective hydrolysis of the nitrile functionality by means of a nitrilase enzyme without affecting the sensitive four-membered ring system, hence overcoming the difficulties associated with the chem. hydrolysis approach. Thus, the implementation of a biocatalytic step allows a convenient synthetic route to new 4-carboxymethyl-β-lactams I (R³ = CO₂H) as versatile building blocks for further elaboration. In the experiment, the researchers used many compounds, for example, (R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8Computed Properties of C6H10O3).

(R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Computed Properties of C6H10O3

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Optimization of novel monobactams with activity against carbapenem-resistant Enterobacteriaceae – Identification of LYS228 was written by Reck, Folkert;Bermingham, Alun;Blais, Johanne;Capka, Vladimir;Cariaga, Taryn;Casarez, Anthony;Colvin, Richard;Dean, Charles R.;Fekete, Alex;Gong, Wanben;Growcott, Ellie;Guo, Hongqiu;Jones, Adriana K.;Li, Cindy;Li, Fengxia;Lin, Xiaodong;Lindvall, Mika;Lopez, Sara;McKenney, David;Metzger, Louis;Moser, Heinz E.;Prathapam, Ramadevi;Rasper, Dita;Rudewicz, Patrick;Sethuraman, Vijay;Shen, Xiaoyu;Shaul, Jacob;Simmons, Robert L.;Tashiro, Kyuto;Tang, Dazhi;Tjandra, Meiliana;Turner, Nancy;Uehara, Tsuyoshi;Vitt, Charles;Whitebread, Steven;Yifru, Aregahegn;Zang, Xu;Zhu, Qingming. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2018.SDS of cas: 15186-48-8 This article mentions the following:

Metallo-β-lactamases (MBLs), such as New Delhi metallo-β-lactamase (NDM-1) have spread world-wide and present a serious threat. Expression of MBLs confers resistance in Gram-neg. bacteria to all classes of β-lactam antibiotics, with the exception of monobactams, which are intrinsically stable to MBLs. However, existing first generation monobactam drugs like aztreonam have limited clin. utility against MBL-expressing strains because they are impacted by serine β-lactamases (SBLs), which are often co-expressed in clin. isolates. Here, we optimized novel monobactams for stability against SBLs, which led to the identification of LYS228 (compound 31). LYS228 is potent in the presence of all classes of β-lactamases and shows potent activity against carbapenem-resistant isolates of Enterobacteriaceae (CRE). In the experiment, the researchers used many compounds, for example, (R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8SDS of cas: 15186-48-8).

(R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.SDS of cas: 15186-48-8

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Effect of mixing methods of polyethylene and cellulose on volatile products from its co-pyrolysis was written by Sophonrat, Nanta;Yang, Weihong. And the article was included in Energy Procedia in 2017.Synthetic Route of C6H10O3 This article mentions the following:

Co-pyrolysis of biomass and plastic wastes is an alternative solution to produce fuel as well as to reduce environmental problem generated from municipal solid waste (MSW). Polyethylene (PE) and cellulose are the main compositions of waste packaging. To produce fuel from these two feedstocks by pyrolysis, the interaction/synergistic effect between them during pyrolysis should be studied. Due to that the interaction should be more pronounced if the two materials are in close contact, the mixing methods of the feedstocks can affect the product yield. In this work, the effect of mixing PE and cellulose on the volatile products from co-pyrolysis was investigated using Py-GC/MS with pyrolysis temperature of 600 °C. The different mixing methods used were, mixing by melting (cellulose powder submerged in PE film) and not mixing. The results showed that when PE and cellulose were not mixed the change in products were not significant, only slight increase in acetic acid was observed When mixed by melting, more oxygenated compounds were produced e.g. higher acetic acid, aliphatic ketones and some pyrans. However, the increases were small and does not significantly affect the main products which were aliphatic hydrocarbons from PE and levoglucosan from cellulose. In the experiment, the researchers used many compounds, for example, (R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8Synthetic Route of C6H10O3).

(R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Synthetic Route of C6H10O3

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Nickel-Catalysed Allylboration of Aldehydes was written by Dennis, Francesca M.;Robertson, Craig C.;Partridge, Benjamin M.. And the article was included in Synthesis in 2020.Category: dioxole This article mentions the following:

A nickel catalyst for the allylboration of aldehydes RCHO (R = 4-chlorophenyl, Ph, pyridin-2-yl, cyclohexyl, 2-phenylethane-1-yl, etc.) is reported, facilitating the preparation of anti-homoallylic alcs. RCH(OH)CH(C₆H₅)CH=CH₂ in high diastereoselectivity. The observed diastereoselectivities and NMR experiments suggest that allylation occurs through a well-defined six-membered transition state, with nickel acting as a Lewis acid. In the experiment, the researchers used many compounds, for example, (R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8Category: dioxole).

(R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Gas-phase sugar formation using hydroxymethylene as the reactive formaldehyde isomer was written by Eckhardt, Andre K.;Linden, Michael M.;Wende, Raffael C.;Bernhardt, Bastian;Schreiner, Peter R.. And the article was included in Nature Chemistry in 2018.Category: dioxole This article mentions the following:

Carbohydrates (CH₂O)_n are the formal adducts of carbon (atoms) to water with a repeating unit that structurally resembles H-C-OH (hydroxymethylene). Although hydroxymethylene has been suggested as a building block for sugar formation, it is a reactive species that had escaped detection until recently. Here we demonstrate that formaldehyde reacts with its isomer hydroxymethylene to give glycolaldehyde in a nearly barrierless reaction. This carbonyl-ene-type transformation operates in the absence of base and solvent at cryogenic temperatures similar to those found in extraterrestrial environments or interstellar clouds. Hydroxymethylene acts as a building block for an iterative sugar synthesis, as we demonstrate through the formation of the triose glyceraldehyde. The thermodynamically preferred ketose dihydroxyacetone does not form, and the formation of further branched sugars in the iterative synthesis presented here is unlikely. The results therefore provide a link between the well-known formose (Butlerow) reaction and sugar formation under non-aqueous conditions. In the experiment, the researchers used many compounds, for example, (R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8Category: dioxole).

(R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Category: dioxole

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Total Synthesis of Disciformycin A and B: Unusually Exigent Targets of Biological Significance was written by Kwon, Yonghoon;Schulthoff, Saskia;Dao, Quang Minh;Wirtz, Conny;Fuerstner, Alois. And the article was included in Chemistry – A European Journal in 2018.SDS of cas: 15186-48-8 This article mentions the following:

The first total synthesis of the potent antibiotic disciformycin B is described, which is exceptionally isomerization-prone and transforms into disciformycin A even under notably mild conditions. To outweigh this bias, the approach to disciformycin B hinged on the use of a silyl residue at C₄ to lock the critical double bond in place and hence insure the integrity of the synthetic intermediates en route to disciformycin B. This tactic was instrumental for the preparation of the building blocks and formation of the macrocyclic ring via ring closing alkyne metathesis. To make the end game successful, however, it proved necessary to cleave the C-silyl protecting group off; it was at this stage that the exceptional sensitivity of the target became fully apparent. In the experiment, the researchers used many compounds, for example, (R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8SDS of cas: 15186-48-8).

(R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.SDS of cas: 15186-48-8

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Copper-Catalyzed One-Pot Synthesis of Pyrrolo[1,2-a]quinoxaline Derivatives from 1-(2-Aminophenyl)-pyrroles and Aldehydes was written by Krishna, Thalishetti;Reddy, Thatikonda Narendar;Laxminarayana, Eppakayala;Kalita, Dipak. And the article was included in ChemistrySelect in 2019.COA of Formula: C6H10O3 This article mentions the following:

A facile and highly efficient copper-catalyzed strategy has been developed for the synthesis of pyrrolo[1,2-a]quinoxalines from 1-(2-aminophenyl)-pyrroles and aldehydes at room temperature This reaction proceeds via imine formation, cyclisation, and oxidation in one-pot. This strategy provides a facile and rapid access to pyrrolo[1,2-a]quinoxalines in good to high yields under mild conditions. This process has several advantages, such as simple reaction procedure, readily available starting materials, low catalyst loading, easy product isolation, broad substrate scope, high functional group tolerance, and gram-scale synthesis. In the experiment, the researchers used many compounds, for example, (R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8COA of Formula: C6H10O3).

(R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.COA of Formula: C6H10O3

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem

Synthesis and Structure-Activity Relationship Studies of Anti-Inflammatory Epoxyisoprostane Analogues was written by Wolleb, Helene;Ogawa, Seiji;Schneider, Michael;Shemet, Andrej;Muri, Jonathan;Kopf, Manfred;Carreira, Erick M.. And the article was included in Organic Letters in 2018.Recommanded Product: 15186-48-8 This article mentions the following:

The lactone derivative of the epoxyisoprostane EC is a highly effective inhibitor of the secretion of the proinflammatory cytokine IL-6. Herein, a modular synthesis of analogs, e.g. I, is described, allowing flexible variations of the cyclic side chain of the parent lactone. A structure-activity relationship study identified a lactam analog that retains the high activity. Furthermore, the exocyclic allylic alc. was shown to be crucial for the observed effect. In the experiment, the researchers used many compounds, for example, (R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8Recommanded Product: 15186-48-8).

(R)-2,2-Dimethyl-1,3-dioxolane-4-carbaldehyde (cas: 15186-48-8) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Recommanded Product: 15186-48-8

Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem