Asymmetric synthesis of (2’R,4’R) and (2’S,4’S)-1,3-dioxolanyl triazole C-nucleosides was written by Qu, Fucheng;Hong, Joon H.;Du, Jinfa;Newton, M. Gary;Chu, Chung K.. And the article was included in Tetrahedron in 1999.HPLC of Formula: 114746-70-2 This article mentions the following:
In view of biol. activities of both 1,3-dioxolanyl nucleosides and C-nucleosides, D- and L-1,3-dioxolanyl C-nucleosides have been synthesized as potential antiviral and/or anticancer agents. Asym. synthesis of four new optically pure D- and L-1,3-dioxolanyl triazole C-nucleosides has been accomplished via key intermediates 5-[(1R/S)-glycol-1-yl]-3-ethoxycarbonyl-1-benzyl-1H-1,2,4-triazole starting from D- and L-2,3-O-isopropylidene glyceraldehyde. The stereochem. assignments of synthesized compounds were unambiguously made based on NMR studies as well as X-ray crystallog. studies. The synthesized nucleosides have been evaluated against HIV and hepatitis B virus, however, no significant antiviral activity was observed In the experiment, the researchers used many compounds, for example, (R)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid (cas: 114746-70-2HPLC of Formula: 114746-70-2).
(R)-2,2-Dimethyl-1,3-dioxolane-4-carboxylic acid (cas: 114746-70-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.HPLC of Formula: 114746-70-2
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem