Category: 106-91-2

106-91-2, Name is Oxiran-2-ylmethyl methacrylate, molecular formula is C7H10O3, SDS of cas: 106-91-2, belongs to dioxoles compound, is a common compound. In a patnet, author is Deng, Chongyang, once mentioned the new application about 106-91-2.

A Novel Small Molecule, (E)-5-(2,4-di-tert-butyl-6-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)-5 ‘-methyl-7,7 ‘-dimethoxy-4,4 ‘-bibenzo[d][1,3]dioxole-5,5 ‘-dicarboxylate (7k), Alleviates the Development of D-Galactosamine/Lipopolysaccharide-Induced Acute Liver Failure by Inhibiting Macrophage Infiltration and Regulating Cytokine Expression

Acute liver failure (ALF) is a relatively rare liver disorder that leads to the massive death of hepatocytes. Our previous study reported that a novel small-molecule agent, (E)-5-(2,4-di-tert-butyl-6-((2,4-dioxothiazolidin-5-ylidene)methyl)phenyl)-5-methyl-7,7′-dimethoxy-4,4′-bibenzo[d][1,3]dioxole-5,5’-dicarboxylate (7k), possessed potent anti-inflammatory activity. In the present study, we further evaluated the therapeutic effects of 7k on lipopolysaccharide (LPS)-induced ALF and investigated the mechanisms of action. Our results demonstrated that 7k inhibited the migration of RAW264.7 macrophages, blocked the activity of nuclear factor-kappa B protein, and dose-dependently down-regulated the production of interleukin (IL)-1 beta, tumor necrosis factor-alpha, and IL-6 as well as their corresponding mRNAs in RAW264.7 cells. Oral administration of 7k at a dose of 50 mg/kg significantly suppressed the serum level of enzyme activity and prevented the damage of liver tissue in D-galactosamine/LPS-induced ALF. Treatment with 7k also remarkably blocked the increase in the number of CD11b(+)- and CD68(+)-positive cells in the liver, and in vivo nuclear factor-kappa B activity, known to regulate inflammatory responses in many cell types, was effectively inhibited. The serum concentrations and hepatic mRNA expression of proinflammatory cytokines tumor necrosis factor-alpha, IL-1 beta, and IL-6 were markedly downregulated in mice by the treatment of 7k. In summary, 7k alleviated the development and progression of D-galactosamine/LPS-induced ALF by inhibiting macrophage infiltration and regulating the expression of cytokines.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 106-91-2. The above is the message from the blog manager. SDS of cas: 106-91-2.

Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 106-91-2, Name is Oxiran-2-ylmethyl methacrylate, SMILES is CC(C(OCC1OC1)=O)=C, in an article , author is Murotani, Eisuke, once mentioned of 106-91-2, Name: Oxiran-2-ylmethyl methacrylate.

Synthesis and polymerization of a novel perfluorinated monomer

Perfluoro(5-methylene-2,2-dimethyl-1,3-dioxolane) (1) was synthesized by utilizing a direct fluorination reaction. Compound 1 was an entirely novel monomer with difluoromethylene at position 5 on the dioxolane ring as an unprecedented polymerization site. It successfully polymerized with tetrafluoroethylene to afford copolymers, which had T-g values in the range of 60-90 degrees C. The content of monomer 1 in the obtained polymers was less than 20 mol%, which seemed insufficient for giving various unique properties to polymers. However, each polymer was expected to be a superior material because of their advanced thermal stability. Comparison with copolymers of 2,2-bis(trifluoromethyl)-4,5-difluoro-1,3-dioxole and tetrafluoroethylene is also discussed. (C) 2007 Elsevier B.V. All rights reserved.

Interested yet? Read on for other articles about 106-91-2, you can contact me at any time and look forward to more communication. Name: Oxiran-2-ylmethyl methacrylate.

Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

Let¡¯s face it, organic chemistry can seem difficult to learn, SDS of cas: 106-91-2, Especially from a beginner¡¯s point of view. Like 106-91-2, Name is Oxiran-2-ylmethyl methacrylate, molecular formula is dioxoles, belongs to dioxoles compound. In a document, author is Yeung, Sing Yee, introducing its new discovery.

Antiproliferative activity of the Antrodia camphorata secondary metabolite 4, 7-dimethoxy-5-methylbenzo [d] [1,3] dioxole and analogues

Both the traditional Chinese medicinal fungus, Antrodia camphorata, and its secondary metabolite, 4,7-dimethoxy-5-methylbenzo[d] [1,3]dioxole, have been reported to possess promising anticancer activity. In this work the natural product and analogues bearing more polar substituents were synthesised and assessed for antiproliferative activity in the NCI-60 screen. Although each compound inhibited the growth of some cell lines at 10 mu M, none had sufficient activity to warrant further investigation.

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Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 106-91-2, Name is Oxiran-2-ylmethyl methacrylate, SMILES is CC(C(OCC1OC1)=O)=C, belongs to dioxoles compound. In a document, author is Zezula, J, introduce the new discover, Product Details of 106-91-2.

Intramolecular Diels-Alder cycloadditions of cis-cyclohexadienediols derived enzymatically from (2-azidoethyl)benzene. Construction of highly functionalized bridged isoquinoline synthons

(3aR,7aS)-4-(2-Azidoethyl)-2,2-dimethyl-3a,7a-dihydrobenzo[1,3]dioxole (22) was converted in two steps to trienes 23 and 24, which upon heating underwent intramolecular Diels-Alder reactions to give mixtures of isomeric 11,11-dimethyl-5-oxo-10,12-dioxa-4-azatetracyclo[6.5.2.0(1.6).0(9,13)]pentadec-14-ene-7-carboxylates 25, 26 and 27, 28, respectively. These products were separated and identified. For comparison, intermolecular Diels-Alder cycloaddition of diene 22 with maleic anhydride was carried out. Products of this reaction, 1-(2-azidoethyl)-4,4-dimethyl-3,5,10-trioxatetracyclo[5.5.2.0(2,6).0(8,12)]tetradec-13-ene-9,11-diones (29 and 30) were converted to methyl ester analogues of 31 and 32 in a two-step sequence. The stereochemical outcome of these cycloadditions is discussed as well as their possible utilization in organic synthesis, especially in total synthesis of some alkaloids.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 106-91-2 is helpful to your research. Product Details of 106-91-2.

Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

Electric Literature of 106-91-2, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 106-91-2, Name is Oxiran-2-ylmethyl methacrylate, SMILES is CC(C(OCC1OC1)=O)=C, belongs to dioxoles compound. In a article, author is Cheng, Wei, introduce new discover of the category.

1-(1,3-Benzodioxol-5-yl)butan-1-one

In the molecule of the title compound, C11H12O3, the dioxole ring adopts an envelope conformation. In the crystal structure, weak intermolecular C-H center dot center dot center dot O hydrogen bonds link the molecules into chains.

Electric Literature of 106-91-2, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 106-91-2.

Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Safety of Oxiran-2-ylmethyl methacrylate, 106-91-2, Name is Oxiran-2-ylmethyl methacrylate, molecular formula is C7H10O3, belongs to dioxoles compound. In a document, author is Kennedy, GL, introduce the new discover.

Inhalation toxicity of Dioxole and Dioxolane compounds in the rat

Four chemicals (Dioxole 418, Dioxolane 418, Dioxolane 416 and Dioxolane 456) which are used as stabilizers in highresolution image were tested or both their acute and repeated inhalation toxicity in the rat using nose-only exposures. Acute studies determined the lethal concentrations following a single 4-hour exposure, repeated exposure inhalation studies determined the potency and target tissue(s) following 6-hour/day exposures, 5 days/week for 2 weeks. Each of the chemicals was at least mildly toxic acutely with approximate lethal concentrations of > 1,500 ppm for Dioxole 418, 1,300 ppm for Dioxolane 418, 1,700 ppm for Dioxolane 416, and 4,300 ppm for Dioxolane 456. No specific unusual clinical signs of response were seen in the rats exposed acutely. Repeated exposures with Dioxole 418 and Dioxolane 418 resulted in no evidence of toxicity with NOAEL’s being 440 and 500 ppm respectively (the highest concentrations tested). Repeated exposures to 250 ppm Dioxolane 456 were not tolerated with mortalities observed after exposure. Severe bone marrow hypoplasia along with reductions in platelet and neutrophil counts were observed at this concentration with less severe hemopoietic changes seen also at 10 and 51 ppm. The no-effect level for Dioxolane 456 was determined to be 10 ppm in female rats and I ppm in males. The same hemopoietic effects were seen with Dioxolane 416 at exposures of 53 ppm or greater in males but not in females exposed to 53 ppm Dioxolane 416. Hepatocellular hypertrophy and depression of serum alkaline phosphatase activity were seen in male rats exposed to 500 but not 53 ppm Dioxolane 416. Testicular degeneration was also seen in rats exposed to 500 ppm Dioxolane 416. The NOAEL was 5 ppm for the chemical.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 106-91-2. Safety of Oxiran-2-ylmethyl methacrylate.

Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem