Lithiation reactions catalyzed by linear and cross-linked arene-based polymers. Generation of functionalized organolithium compounds was written by Candela, P.;Gomez, C.;Yus, M.. And the article was included in Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii) in 2004.Computed Properties of C7H13ClO2 This article mentions the following:
Lithiation of various substrates, such as chlorinated acetals (e.g. 2-(4-chlorobutyl)-1,3-dioxolane), α-chloro ether, dichloro derivatives, benzo-fused heterocycles (e.g. isobenzofuran), and allyl and benzyl derivatives, with excess Li powder in the presence of a catalytic amount of soluble linear or insoluble cross-linked arene (naphthalene or biphenyl)-based polyolefins, yields the expected organolithium intermediates. The latter react with electrophiles (e.g. Et2CO) either in two steps or under Barbier-type reaction conditions to afford the corresponding adducts. The catalyst is easily recuperated by filtration at the end of the process, and the procedure can be regarded as a reasonable alternative to the use of free arenes as electron carrier in lithiation reactions. In the experiment, the researchers used many compounds, for example, 2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0Computed Properties of C7H13ClO2).
2-(4-Chlorobutyl)-1,3-dioxolane (cas: 118336-86-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Computed Properties of C7H13ClO2
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem