Synthesis and cardiotonic activity of a series of substituted 4-alkyl-2(1H)-quinazolinones was written by Bandurco, Victor T.;Schwender, Charles F.;Bell, Stanley C.;Combs, Donald W.;Kanojia, Ramesh M.;Levine, Seymour D.;Mulvey, Dennis M.;Appollina, Mary A.;Reed, Marianne S.. And the article was included in Journal of Medicinal Chemistry in 1987.Reference of 28657-75-2 This article mentions the following:
The synthesis, cardiac fraction III cyclic nucleotide phosphodiesterase (PDE-III) inhibition, and pos. inotropic activity of a series of 2(1H)-quinazolinones are reported. A general synthesis of the series involves the cyclization of 2-aminoacetophenones with KOCN in AcOH. Modifications at the 4-position of the quinazoline nucleus are best achieved by forming the intermediate N1-acyl-N3-phenylurea from the appropriate substituted PhNCO and amide. Polyphosphoric acid effects cyclizaiton to the quinazoline product. Generally the structure-activity relationships for the series parallel the 5-point model previously published for PDE-III inhibition. The most active analog of the series is 5,6-dimethoxy-4-methyl-2(1H)-quinazolinone (I) (ORF 16,600), which has ca. twice the i.v. potency of amrinone and is being developed as an oral cardiotonic. In the experiment, the researchers used many compounds, for example, 1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2Reference of 28657-75-2).
1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Reference of 28657-75-2
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem