Safety of 2-Bromomethyl-1,3-dioxolane. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-Bromomethyl-1,3-dioxolane, is researched, Molecular C4H7BrO2, CAS is 4360-63-8, about Assembly of multicyclic isoquinoline scaffolds from pyridines: formal total synthesis of fredericamycin A. Author is Wang, Fang-Xin; Yan, Jia-Lei; Liu, Zhixin; Zhu, Tingshun; Liu, Yingguo; Ren, Shi-Chao; Lv, Wen-Xin; Jin, Zhichao; Chi, Yonggui Robin.
The construction of an isoquinoline skeleton typically starts with benzene derivatives as substrates with the assistance of acids or transition metals. Disclosed here is a concise approach to prepare isoquinoline analogs by starting with pyridines to react with β-ethoxy α,β-unsaturated carbonyl compounds under basic conditions. Multiple substitution patterns and a relatively large number of functional groups (including those sensitive to acidic conditions) can be tolerated the method. In particular, protocol allows for efficient access to tricyclic isoquinolines found in hundreds of natural products with interesting bioactivities. The efficiency and operational simplicity of introducing structural complexity into the isoquinoline frameworks can likely enable the collective synthesis of a large set of natural products. Here show that fredericamycin A could be obtained via a short route by using isoquinoline synthesis as a key step.
I hope my short article helps more people learn about this compound(2-Bromomethyl-1,3-dioxolane)Safety of 2-Bromomethyl-1,3-dioxolane. Apart from the compound(4360-63-8), you can read my other articles to know other related compounds.
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem