A Comparative Human Health Risk Assessment of p-Dichlorobenzene-Based Toilet Rimblock Products Versus Fragrance/Surfactant-Based Alternatives was written by Aronson, Dallas B.;Bosch, Stephen;Gray, D. Anthony;Howard, Philip H.;Guiney, Patrick D.. And the article was included in Journal of Toxicology and Environmental Health in 2007.Synthetic Route of C8H14O4 The following contents are mentioned in the article:
Consumer human health risks from using 1 of 2 types of toilet rimblock products, a p-dichlorobenzene-based rimblock or 2 newer fragrance/surfactant-based alternatives, were assessed. Rimblock products, designed for consumer use worldwide, function by releasing volatile compounds into indoor air with subsequent exposure presumed to be mainly via inhalation. Using the THERdbASE exposure model and exptl. determined emission data, indoor air concentrations and daily intake values were determined for both types of rimblock products. Modeled exposure concentrations from a representative p-dichlorobenzene rimblock product were 1 order of magnitude higher than those from the alternative rimblock products due to its nearly pure composition and high sublimation rate. Lifetime exposure to p-dichlorobenzene or the subset of fragrance components with available reference dose values was not expected to lead to non-cancer-based adverse health effects based on exposure concentrations estimated using the THERdbASE model. A similar comparison of cancer-based effects was not possible since insufficient data were available for the fragrance components. This study involved multiple reactions and reactants, such as Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1Synthetic Route of C8H14O4).
Ethyl 2-(2-methyl-1,3-dioxolan-2-yl)acetate (cas: 6413-10-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Although benzodioxole is not particularly important, many related compounds containing the methylenedioxyphenyl group are bioactive, and thus are found in pesticides and pharmaceuticals.Synthetic Route of C8H14O4
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem