Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 7524-52-9, is researched, SMILESS is N[C@@H](CC1=CNC2=CC=CC=C12)C(OC)=O.[H]Cl, Molecular C12H15ClN2O2Preprint, ChemRxiv called Chemical synthesis of (+)-brevianamide A supports a Diels-Alderase-free biosynthesis, Author is Godfrey, Robert C.; Green, Nicholas J.; Nichol, Gary S.; Lawrence, Andrew L., the main research direction is brevianamide A synthesis Diels Alder reaction.Safety of H-Trp-OMe.HCl.
The fungal-derived bicyclo[2.2.2]diazaoctane alkaloids are of significant interest to the scientific community for their potent and varied biol. activities. Within this large and diverse family of natural products the insecticidal metabolite (+)-brevianamide A is particularly noteworthy for its synthetic intractability and inexplicable biogenesis. Despite five decades of research, this alkaloid has never succumbed to chem. synthesis. It has been suggested that a proposed Diels-Alder reaction in the biosynthesis of (+)-brevianamide A requires a Diels-Alderase enzyme. We herein report the first chem. synthesis of (+)-brevianamide A (7 steps, 8.0% overall yield, 750 mg scale), which provides compelling evidence in support of a Diels-Alderase-free biosynthesis; a significant departure from the established biosynthesis of related alkaloids.
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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem