Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 455-70-9, is researched, SMILESS is COC(=O)C1=CC(F)=CN=C1, Molecular C7H6FNO2Journal, Article, Chemical Communications (Cambridge, United Kingdom) called A predictive model for additions to N-alkyl pyridiniums, Author is Knight, Brian J.; Tolchin, Zachary A.; Smith, Joel M., the main research direction is pyridine Grignard methyl triflate regioselective dearomative addition; dihydropyridine preparation.Product Details of 455-70-9.
Disclosed in this communication is a thorough study on the dearomative addition of organomagnesium nucleophiles to N-alkyl pyridinium electrophiles. The regiochem. outcomes have observable and predictable trends associated with the substituent patterns on the pyridinium electrophile. Often, the substituent effects can be either additive, giving high selectivities, or ablative, giving competing outcomes. Addnl., the nature of the organometallic nucleophilic component was also investigated for its role in the regioselective outcome. The effects of either reactive component are important to both the overall reactivity and site of nucleophilic addition The utility of these observed trends is demonstrated in a concise, dearomative synthesis of a tricyclic compound shown to have insecticidal activity.
This literature about this compound(455-70-9)Product Details of 455-70-9has given us a lot of inspiration, and I hope that the research on this compound(Methyl 5-fluoro-3-pyridinecarboxylate) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem