So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Frydrych, Jan; Slaveetinska, Lenka Postova; Draccinsky, Martin; Janeba, Zlatko researched the compound: 2-Bromomethyl-1,3-dioxolane( cas:4360-63-8 ).Application of 4360-63-8.They published the article 《Efficient synthesis of α-branched purine-based acyclic nucleosides: scopes and limitations of the method》 about this compound( cas:4360-63-8 ) in Molecules. Keywords: acyclonucleoside preparation; nitrogen heterocycle acetal anhydride alkylation; acyclonucleosides; hemiaminal ether; multi-component reaction; purine. We’ll tell you more about this compound (cas:4360-63-8).
An efficient route to acylated acyclic nucleosides containing a branched hemiaminal ether moiety was reported via three-component alkylation of N-heterocycle (purine nucleobase) with acetal (cyclic or acyclic, variously branched) and anhydride (preferentially acetic anhydride). The procedure employed cheap and easily available acetals, acetic anhydride, and trimethylsilyl trifluoromethanesulfonate (TMSOTf). The multi-component reaction was carried out in acetonitrile at room temperature for 15 min and provides moderate to high yields (up to 88%) of diverse acyclonucleosides branched at the aliphatic side chain. The procedure exhibited a broad substrate scope of N-heterocycles and acetals, and, in the case of purine derivatives, also excellent regioselectivity, giving almost exclusively N-9 isomers.
Although many compounds look similar to this compound(4360-63-8)Application of 4360-63-8, numerous studies have shown that this compound(SMILES:BrCC1OCCO1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem