On November 30, 2003, Abdel-Rahman, Adel A.-H.; Abdel-Megied, Ahmed E.-S.; Goda, Adel E.-S.; Zeid, Ibrahim F.; El Ashry, El Sayed H. published an article.Recommanded Product: (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole The title of the article was Synthesis and Anti-HBV Activity of Thiouracils Linked via S and N-1 to the 5-Position of Methyl β-D-Ribofuranoside. And the article contained the following:
Reverse nucleoside derivatives of 2-(methylsulfanyl)uracils, e.g. I (RR = CMe2), were prepared by treating of the sodium salt of 2-(methylsulfanyl)uracils with Me 2,3-O-isopropylidene-5-O-p-toluenesulfonyl-β-D-ribofuranoside. The alkylation of 2-thiouracils with Me 5-deoxy-5-iodo-2,3-O-isopropylidene-D-ribofuranoside afforded the corresponding S-ribofuranoside derivatives which were deprotected to give nucleoside analogs, e.g. II (R = H). The Anti-HBV activity of selected compounds was studied. I (R = H) was found to be active against HBV replication with IC50 = 90 μM and CC50 > 100 μM. The experimental process involved the reaction of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole(cas: 38838-06-1).Recommanded Product: (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole
The Article related to nucleoside analog synthesis antiviral hbv human, Carbohydrates: Nucleosides and Nucleotides, Cobalamins, Riboflavin and other aspects.Recommanded Product: (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem