So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Wang, Haiqi; Song, Hongjian researched the compound: H-Trp-OMe.HCl( cas:7524-52-9 ).Quality Control of H-Trp-OMe.HCl.They published the article 《Synthesis of Four Optical Isomers of Antiviral Agent NK0209 and Determination of Their Configurations and Activities against a Plant Virus》 about this compound( cas:7524-52-9 ) in Journal of Agricultural and Food Chemistry. Keywords: NK0209 isomer preparation antiviral tobacco mosaic virus antiviral; NK0209; antiviral activity; isomers; spatial configuration; synthesis. We’ll tell you more about this compound (cas:7524-52-9).
Previously, we reported for the first time that harmala alkaloids harmine and tetrahydroharmine exhibit activity against plant viruses, and we developed an analog, designated NK0209, that efficiently prevents and controls plant virus diseases. Here, to investigate the influence of the spatial configuration of NK0209 on its antiviral activities, we synthesized its four optical isomers, determined their configurations, and evaluated their activities against tobacco mosaic virus. All four isomers were significantly more active than ningnanmycin, which is one of the most successful com. antiviral agents, with in vivo inactivation, cure, and protection rates of 57.3±1.9%, 54.2±3.3%, 55.0±4.1% at 500μg/mL. Furthermore, anal. of structure-activity relationships demonstrated for the first time that the spatial conformation of NK0209 is an important determinant of its antiviral activity, and our results provide information about the possible optimum configuration for interaction of this mol. with its target protein.
After consulting a lot of data, we found that this compound(7524-52-9)Quality Control of H-Trp-OMe.HCl can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem