So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Khalili Foumeshi, Maryam; Ziyaei Halimehjani, Azim; Alaei, Ali; Klepetarova, Blanka; Beier, Petr researched the compound: H-Trp-OMe.HCl( cas:7524-52-9 ).Application of 7524-52-9.They published the article 《Tandem Alkylation/Michael Addition Reaction of Dithiocarbamic Acids with Alkyl γ-Bromocrotonates: Access to Functionalized 1,3-Thiazolidine-2-thiones》 about this compound( cas:7524-52-9 ) in Synthesis. Keywords: primary amine carbon disulfiide alkyl bromocrotonate alkylation Michael addition; thiazolidinethione preparation. We’ll tell you more about this compound (cas:7524-52-9).
Thiazolidine-2-thiones were prepared via a novel multicomponent reaction of primary amines (amino acids), carbon disulfide, and γ-bromocrotonates. The reaction proceeded via a domino alkylation/intramol. Michael addition to provide the corresponding thiazolidine-2-thiones in high to excellent yields. By using diamines in this protocol, bis(thiazolidine-2-thiones) derivatives were synthesized. The synthetic utility of the adducts was demonstrated by hydrolysis, amidation, and oxidation reactions.
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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem