The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Chloropyridin-3-amine(SMILESS: NC1=CC(=CN=C1)Cl,cas:22353-34-0) is researched.Electric Literature of C34H22NO2P. The article 《Discovery of Cytochrome P450 4F11 Activated Inhibitors of Stearoyl Coenzyme A Desaturase》 in relation to this compound, is published in Journal of Medicinal Chemistry. Let’s take a look at the latest research on this compound (cas:22353-34-0).
Stearoyl-CoA desaturase (SCD) catalyzes the first step in the conversion of saturated fatty acids to unsaturated fatty acids. Unsaturated fatty acids are required for membrane integrity and for cell proliferation. For these reasons, inhibitors of SCD represent potential treatments for cancer. However, systemically active SCD inhibitors result in skin toxicity, which presents an obstacle to their development. We recently described a series of oxalic acid diamides that are converted into active SCD inhibitors within a subset of cancers by CYP4F11-mediated metabolism Herein, we describe the optimization of the oxalic acid diamides and related N-acyl ureas and an anal. of the structure-activity relationships related to metabolic activation and SCD inhibition.
In addition to the literature in the link below, there is a lot of literature about this compound(5-Chloropyridin-3-amine)Reference of 5-Chloropyridin-3-amine, illustrating the importance and wide applicability of this compound(22353-34-0).
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem