A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, COA of Formula: C6H12O7, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 526-95-4, Name is Gluconic Acid (contains Gluconolactone), molecular formula is C6H12O7. In an article, author is Nijenhuis, Cynthia M.,once mentioned of 526-95-4.
Metabolite profiling of C-14-omacetaxine mepesuccinate in plasma and excreta of cancer patients
1. Omacetaxine mepesuccinate (hereafter referred to as omacetaxine) is a protein translation inhibitor approved by the US Food and Drug Administration for adult patients with chronic myeloid leukemia with resistance and/or intolerance to two or more tyrosine kinase inhibitors. 2. The objective was to investigate the metabolite profile of omacetaxine in plasma, urine and faeces samples collected up to 72h after a single 1.25-mg/m(2) subcutaneous dose of C-14-omacetaxine in cancer patients. 3. High-performance liquid chromatography mass spectrometry (MS) (high resolution) in combination with off-line radioactivity detection was used for metabolite identification. 4. In total, six metabolites of omacetaxine were detected. The reactions represented were mepesuccinate ester hydrolysis, methyl ester hydrolysis, pyrocatechol conversion from the 1,3-dioxole ring. Unchanged omacetaxine was the most prominent omacetaxine-related compound in plasma. In urine, unchanged omacetaxine was also dominant, together with 4′-DMHHT. In feces very little unchanged omacetaxine was found and the pyrocatechol metabolite of omacetaxine, M534 and 4′-desmethyl homoharringtonine (4′-DMHHT) was the most abundant metabolites. 5. Omacetaxine was extensively metabolized, with subsequent renal and hepatic elimination of the metabolites. The low levels of the metabolites found in plasma indicate that the metabolites are unlikely to contribute materially to the efficacy and/or toxicity of omacetaxine.
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Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem