The effect of nutmeg essential oil constituents on Novikoff hepatoma cell viability and communication through Cx43 gap junctions was written by Mickus, Rokas;Janciuke, Gintare;Raskevicius, Vytautas;Mikalayeva, Valeryia;Matulyte, Inga;Marksa, Mindaugas;Maciunas, Kestutis;Bernatoniene, Jurga;Skeberdis, Vytenis Arvydas. And the article was included in Biomedicine & Pharmacotherapy in 2021.Category: dioxole This article mentions the following:
Essential oils from plants are a potential source of mols. having anti-inflammatory, anticancer, cardiotropic, and other activities. However, most of these effects lack mechanistic explanations and structure-activity relationship testing. In the present study, we: (1) identified the nutmeg essential oil (NEO) composition; (2) using mol. docking, we determined the putative regulatory binding sites on the connexin 43 (Cx43) that is responsible for gap junction-dependent intercellular communication (GJIC) in the majority of tissues; (3) examined the effect of NEO and its three constituents – sabinene, α-pinene, and α-copaene – on GJ conductance and gating in Novikoff cells expressing endogenous Cx43; and (4) verified whether NEO effects on GJIC correlated with its action on Novikoff cell viability, proliferation, and colony formation capability. Our results revealed NEO and its constituents as potent and efficient Cx43 GJ inhibitors acting by slow gating mechanism. In addition, NEO reduced Novikoff hepatoma cell viability, proliferation, and colony formation capability; however, this was achieved at higher doses and was unrelated to its effects on GJIC. In the experiment, the researchers used many compounds, for example, 6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0Category: dioxole).
6-Allyl-4-methoxybenzo[d][1,3]dioxole (cas: 607-91-0) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.Category: dioxole
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem