Rh(III)-Catalyzed Tandem Reaction Access to (Quinazolin-2-yl)methanone Derivatives from 2,1-Benzisoxazoles and α-Azido Ketones was written by Liu, Shan;Wang, An-Jing;Li, Min;Zhang, Jing;Yin, Guo-Dong;Shu, Wen-Ming;Yu, Wei-Chu. And the article was included in Journal of Organic Chemistry in 2022.Safety of 1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone This article mentions the following:
A Rh(III)-catalyzed tandem reaction for the synthesis of (quinazolin-2-yl)methanone derivatives was been explored from 2,1-benzisoxazoles and α-azido ketones. The transformation involved Rh(III)-catalyzed denitrogenation of α-azido ketones, aza-[4 + 2] cycloaddition, ring opening, and dehydration aromatization processes. Notably, the aza-[4 + 2] cycloaddition of an imine rhodium complex intermediate with 2,1-benzisoxazoles was key to this reaction. In the experiment, the researchers used many compounds, for example, 1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2Safety of 1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone).
1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone (cas: 28657-75-2) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.Safety of 1-(6-Aminobenzo[d][1,3]dioxol-5-yl)ethanone
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem