A study of deketalization of rigid β-aminoketones was written by Kim, Jack C.;Lee, Yong Tae;Yoon, Ung Chan;Cho, In Seop;Moon, Sung Hwan;Han, Sun Hong. And the article was included in Taehan Hwahakhoe Chi in 1988.SDS of cas: 3418-21-1 This article mentions the following:
The causes of failure in the deketalization of rigid β-aminoketals were sep. investigated by examining the deketalization of ketals I (R = NH2, N+Me3, NHAc), and by examining the deketalization of non-rigid β-aminoketal 2-amino-1-ethylenedioxyacetophenone (II) and non-rigid aliphatic acetals R1CH(OMe)2 (III, R1 = NMe2, CH2NH2). While I (R = NH2, N+Me3) were not hydrolyzed in the various acidic conditions, I (R = NHAc) was easily deketalized. These results indicate the importance of electrostatic repulsion in the dicationic intermediates as a factor in the failure of deketalization. The easy deketalization of compounds II and III indicate that the structural characters of rigid β-aminoketals are also important factors in the hydrolysis of β-aminoketals. In the experiment, the researchers used many compounds, for example, 2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1SDS of cas: 3418-21-1).
2-(Bromomethyl)-2-phenyl-1,3-dioxolane (cas: 3418-21-1) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. 1,3-Benzodioxole can be synthesized from catechol with disubstituted halomethanes.SDS of cas: 3418-21-1
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem