144690-92-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Triphenyl methyl olmesartan, cas is 144690-92-6,the Dioxole compound, it is a common compound, a new synthetic route is introduced below.
Example 8; Olmesartan medoxomil (V); Water (10 g) was added to a solution of the starting substance (III; 20 g) in acetone (50 ml), and the mixture was heated to a mild boil for 14 h. After the reaction was completed, the mixture was cooled to 0 0C, and the formed trityl alcohol was sucked off. After concentration, a crude product was obtained, which was extracted with ethyl acetate (70 ml). After evaporating the extract and crystallizing from acetone, 10.6 g (76 %) of the product with an HPLC purity of 97.0 % was obtained. Recrystallization from ethyl methyl ketone gave 10.2 g (73 %) of the product with an HPLC purity of 99.3 %; m.p. 175-177 C.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Triphenyl methyl olmesartan, 144690-92-6
Reference£º
Patent; ZENTIVA, A.S.; WO2007/48361; (2007); A1;,
1,3-Benzodioxole – Wikipedia
Dioxole | C3H4O2 – PubChem