Braun, Manfred published the artcilePalladium-catalyzed diastereoselective and enantioselective allylic alkylations of ketone enolates, HPLC of Formula: 503538-69-0, the publication is Advanced Synthesis & Catalysis (2008), 350(2), 303-314, database is CAplus.
Lithium and magnesium enolates of cyclohexanone undergo palladium-catalyzed allylic alkylations under mild conditions. Diastereoselectivity and enantioselectivity are observed when the diphenyl- and dimethyl-substituted allylic substrates are reacted with cyclohexanone or Et mesityl ketone. The lithium enolates of cyclohexanone, cyclopentanone and α-tetralone lead to the alkylations products in an enantioselective manner. Axially chiral biphenyl- and binaphthyl-bisphosphanes provide high enantioselectivity and/or diastereoselectivity. In the case of the lithium enolates, the presence of lithium chloride is also crucial to reactivity and stereoselectivity. The stereochem. outcome of the allylic alkylation of cyclohexanone and acetophenone has been investigated by the palladium-catalyzed reaction of their lithium enolates with the cis/trans isomeric alkenes. It turns out that the preformed, non-stabilized enolates attack π-allyl-palladium complexes generated in situ from the face opposite to the noble metal thus following the stereochem. pathway of soft, stabilized carbanions.
Advanced Synthesis & Catalysis published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C38H24F4O4P2, HPLC of Formula: 503538-69-0.
Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem