Shan, Gang published the artcileC-H Bond Activation for the Synthesis of Heterocyclic Atropisomers Yields Hedgehog Pathway Inhibitors, Recommanded Product: (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, the publication is Angewandte Chemie, International Edition (2018), 57(43), 14250-14254, database is CAplus and MEDLINE.
In the presence of a nonracemic cyclopentenopyridine rhodium complex, O-(arylpentynyl) arylhydroxamates such as I underwent enantioselective C-H activation and cyclization reactions mediated by dibenzoyl peroxide and CsOAc in 2-chloroethanol/1,2-dichloroethane to yield atropisomeric arylisoquinolinones such as II in 45-95% yields and in 78:22-96:4 er. Five of the arylisoquinolinone products (including II) inhibited the Hedgehog pathway in human cells; one of the compounds tested inhibited the Hedgehog pathway but did not displace labeled cyclopamine from Smoothened, implying that at least one of the arylisoquinolinones does not inhibit the Hedgehog pathway through binding to Smoothened.
Angewandte Chemie, International Edition published new progress about 503538-69-0. 503538-69-0 belongs to dioxole, auxiliary class (Atropisomeric Bisphosphine Ligands, name is (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole, and the molecular formula is C18H34N4O5S, Recommanded Product: (R)-5,5′-Bis(diphenylphosphino)-2,2,2′,2′-tetrafluoro-4,4′-bi-1,3-benzodioxole.
Referemce:
https://en.wikipedia.org/wiki/1,3-Benzodioxole,
Dioxole | C3H4O2 – PubChem