Hanessian, S.; Lavallee, P. published an article in 1976, the title of the article was Direct replacement of primary hydroxyl groups by halogen.Name: (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole And the article contains the following content:
Approx. 1:1 Ph3P and N-halosuccinimide (halo = Br, Cl, iodo) in DMF gave selective halogenation of primary OH groups in polyols. Thus, addition of Ph3P to Me 2,3-O-isopropylidene-β-D-ribofuranoside and N-iodosuccinimide in DMF yielded 71% Me 5-deoxy-5-iodo-2,3-O-isopropylidene-β-D-ribofuranoside. Similarly prepared were Me 2,3,4-tri-O-acetyl-6-bromo-6-deoxy-α-D-glucopyranoside, 5′-bromo-5′-deoxy-2′,3′-O-isopropylideneuridine, and 6-bromo-6-deoxy-α,α-trehalose heptoacetate. The experimental process involved the reaction of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole(cas: 38838-06-1).Name: (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole
The Article related to hydroxyl group halogenation selective, glycoside selective halogenation, nucleoside selective halogenation, Carbohydrates: Glycosides and other aspects.Name: (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem