On June 13, 2019, Verhoeven, Jonas; Verniest, Guido Alfons F.; Thuring, Johannes Wilhelmus John F.; Wu, Tongfei; Pande, Vineet; Meerpoel, Lieven; Brehmer, Dirk; Sun, Weimei; Denmark, Scott E. published a patent.Quality Control of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole The title of the patent was Preparation of spirobicyclic nucleoside analogs as PRMT5 enzyme inhibitors. And the patent contained the following:
Spirobicyclic analogs I, wherein R1 and R2 are independently H, acyl; X is H; Y is O, CH2, CF2; Q1 is substituted C; Q2 is N or substituted C; R3a is H, halo, substituted amine, alkyl, alkenyl, cycloalkyl, OH, O-alkyl; L is CH2, O-CH2, CH2-O, O; R5 is Ph, aryl, monocyclic heterocycle, bicyclic heterocycle; and in case L is O or O-CH2, R5 can also represent H; were prepared and used as PRMT5 inhibitors. Thus, spirobicyclic nucleoside II was prepared as PRMT5 enzyme inhibitor and antitumor agent. The experimental process involved the reaction of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole(cas: 38838-06-1).Quality Control of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole
The Article related to spirobicyclic nucleoside preparation prmt5 inhibitor methyltransferase protein arginine antitumor, Carbohydrates: Nucleosides and Nucleotides, Cobalamins, Riboflavin and other aspects.Quality Control of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem