On April 30, 2007, Braga, Fernanda Gambogi; Coimbra, Elaine Soares; Matos, Magnum de Oliveira; Lino Carmo, Arturene Maria; Cancio, Marisa Damato; da Silva, Adilson David published an article.Application of 38838-06-1 The title of the article was Synthesis and biological evaluation of some 6-substituted purines. And the article contained the following:
We report herein the synthesis and the in vitro antileishmanial evaluation of a series of 6-substituted purines. The most active compounds against Leishmania amazonensis promastigotes were 6-(3′-chloropropylthio)purine [I; R = CH2CH2CH2Cl; (D.A. Benson, I. Karsch-Mizrachi, D.J. Lipman, J. Ostell, B.A. Rapp, D.L. Wheeler, Genbank. Nucleic Acids Res. 28 (2000) 15-18; E.V. Aleksandrova, P.M.I.E. Valashek, J. Med. Pharm. Chem. 35 (2001) 172-173)], 6-(3′-(thioethylamine)propylthio)purine [I; R = CH2CH2CH2SCH2CH2NH2], 6-(α-aceticacidthio)purine [I; R = CH2CO2H] and 6-(6′-deoxy-1′-O-methyl-β-D-ribofuranose)purine [I; R = R’] with an IC50 = 50, 50, 39 and 29 μM, resp. The experimental process involved the reaction of (3aS,4S,6R,6aR)-4-(Iodomethyl)-6-methoxy-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole(cas: 38838-06-1).Application of 38838-06-1
The Article related to purine alkylthio preparation antileishmanial, cytotoxicity leishmania alkylthiopurine derivative, Biomolecules and Their Synthetic Analogs: Others, Including Purines, Pyrimidine Nucleic Acid Bases, Flavins, Lignans and other aspects.Application of 38838-06-1
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem