The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: H-Trp-OMe.HCl( cas:7524-52-9 ) is researched.Quality Control of H-Trp-OMe.HCl.Martinez-Mingo, Mario; Rodriguez, Nuria; Gomez Arrayas, Ramon; Carretero, Juan C. published the article 《Access to Benzazepinones by Pd-Catalyzed Remote C-H Carbonylation of γ-Arylpropylamine Derivatives》 about this compound( cas:7524-52-9 ) in Organic Letters. Keywords: benzazepinone preparation palladium catalyst gamma arylpropylamine carbonylation. Let’s learn more about this compound (cas:7524-52-9).
A general method for the construction of seven-membered rings through Pd-catalyzed C(sp2)-H carbonylation at the remote ε-position of γ-arylpropylamine derivatives, including chiral α-amino acids, was developed using Mo(CO)6 as the CO source, furnishing richly functionalized benzo[c]azepin-1-one derivatives The readily removable N-SO2Py protecting/directing group provides high levels of chemo-, regio- and diastereoselectivity. Furthermore, this method is amenable to the postsynthetic modification of complex mols. such as small peptides.
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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem