In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Incorporation of the pentafluorosulfanyl group through common synthetic transformations, published in 2021-04-30, which mentions a compound: 7524-52-9, mainly applied to amino acid pentafluorosulfanyl synthesis synthon; amide coupling reaction mechanism reductive amination; Click chem azide alkyne cycloaddition copper catalyst, Related Products of 7524-52-9.
The incorporation of SF5 group into model amino acids has been achieved using com. available synthons substituted with this group. This work investigates the influence of the -SF5 group on a variety of common synthetic transformations utilized in fields of bioconjugation and drug development, namely, amide coupling, reductive amination, diazo-coupling, and CuAAC “”Click”” reactions. The influence of the novel substituent on the success of these common transformations is presented, and alternative approaches for those which proved unsatisfactory are proposed herein.
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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem