Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 4360-63-8, is researched, Molecular C4H7BrO2, about Transition-Metal-Free Deconstructive Lactamization of Piperidines, the main research direction is piperidine regioselective Baeyer Villiger oxidation decarboxylative intramol translactamization green; pyrrolidinone one pot preparation; Baeyer-Villiger oxidation; deconstructive functionalization; nitrogen heterocycles; piperidines; pyrrolidinones.Reference of 2-Bromomethyl-1,3-dioxolane.
One of the major challenges in organic synthesis is the activation or deconstructive functionalization of unreactive C(sp3)-C(sp3) bonds, which requires using transition or precious metal catalysts. We present here an alternative: the deconstructive lactamization of piperidines without using transition metal catalysts. To this end, we use 3-alkoxyamino-2-piperidones, which were prepared from piperidines through a dual C(sp3)-H oxidation, as transitory intermediates. Exptl. and theor. studies confirm that this unprecedented lactamization occurs in a tandem manner involving an oxidative deamination of 3-alkoxyamino-2-piperidones to 3-keto-2-piperidones, followed by a regioselective Baeyer-Villiger oxidation to give N-carboxyanhydride intermediates, which finally undergo a spontaneous and concerted decarboxylative intramol. translactamization.
Here is just a brief introduction to this compound(4360-63-8)Reference of 2-Bromomethyl-1,3-dioxolane, more information about the compound(2-Bromomethyl-1,3-dioxolane) is in the article, you can click the link below.
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem