Tarasova, O. A.; Nedolya, N. A.; Albanov, A. I.; Trofimov, B. A. published the article 《Unexpected Formation of Thiophene in the Pyrrole Synthesis from Methoxyallene and Methyl Isothiocyanate》. Keywords: lithiated methoxyallene methyl isothiocyanate bromomethyl dioxolane copper cyclization; dioxolanylmethyl methoxythiophenamine preparation.They researched the compound: 2-Bromomethyl-1,3-dioxolane( cas:4360-63-8 ).HPLC of Formula: 4360-63-8. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:4360-63-8) here.
The sequential reaction of lithiated methoxyallene, Me isothiocyanate, and 2-(bromomethyl)-1,3-dioxolane in the presence of CuBr yields a 2,3-disubstituted thiophene instead of the expected pyrrole. The process was accomplished in one preparative stage and involved intramol. cyclization of the in situ-generated lithium allenylimidothioate and N-alkylation of the resulting lithium thienylamide. Varying the reaction conditions did not affect its route: in all cases, the only product was N-(1,3-dioxolan-2-ylmethyl)-3-methoxy-N-methylthiophen-2-amine.
Compound(4360-63-8)HPLC of Formula: 4360-63-8 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(2-Bromomethyl-1,3-dioxolane), if you are interested, you can check out my other related articles.
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem