Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide, is researched, Molecular C11H13OP, CAS is 707-61-9, about Synthesis of some 1-aryl-2,3-dibromophospholanes as novel anti-cancer agents.Related Products of 707-61-9.
Novel phosphorus heterocyclic compounds, 3-methyl-1-(3-bromophenyl as well as some 3-substituted phenyl)-2-phospholene 1-oxides, were synthesized from 1-phenyl-2-phospholene 1-oxide via 3-methyl-1-(3-nitrophenyl)-2-phospholene 1-oxide. 1-(4-Bromophenyl)-2-phospholene was prepared by Grignard coupling reaction of 1-chloro-3-methyl-2-phospholene 1-oxide with 4-bromophenylmagnesium bromide. 2,3-Dibromo-3-methyl-1-arylphospholane 1-oxides were prepared by the addition reaction of bromine to the C=C double bond of 2-phospholenes. The substituent effect of the Ph group of the 1-aryl-phospholanes on the observed anti-proliferative effect against U937 leukemia cell lines evaluated by MTT in vitro methods showed that 2,3-dibromo-3-methyl-1-(4-bromophenyl)phospholane was the most active among 1-arylphospholanes. These novel dibromophosphorus heterocyclic derivatives exhibit much higher anticancer activity than Gleevec (mol. targeting chemotherapeutic agent) against U937 cells.
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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem