Application of 7524-52-9. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: H-Trp-OMe.HCl, is researched, Molecular C12H15ClN2O2, CAS is 7524-52-9, about Au(I)-Catalyzed Domino Cyclization of 1,6-Diynes Incorporated with Indole. Author is Chen, Guzhou; Liu, Peng-Yu; Zou, Huanhuan; Hu, Jiadong; Fang, Xiaowu; Xu, Dongyang; He, Yu-Peng; Wei, Hongbo; Xie, Weiqing.
Herein a Au(I)-catalyzed domino cyclization of 1,6-diynes incorporated with indole was disclosed. This protocol enabled the diastereoselective buildup of indole-fused azabicyclo[3.3.1]nonanes from linear precursors. D. functional theory calculations showed that the reaction proceeded via an unprecedented cascade dearomatization/rearomatization/dearomatization process. Independent gradient model anal. revealed that a noncovalent attractive interaction between the distal alkyne and the Au/proximal complex was responsible for the chemoselectivity of the first spirocyclization step.
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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem