Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Methyl 5-fluoro-3-pyridinecarboxylate, is researched, Molecular C7H6FNO2, CAS is 455-70-9, about A general synthesis of substituted fluorenones and azafluorenones.Safety of Methyl 5-fluoro-3-pyridinecarboxylate.
Twenty-one variously substituted fluorenones and azafluorenones I (X, X1, X2 = CH, N; R, R1 = H, alkyl, halo, etc.) were prepared The key ring-forming step was photochem. Pschorr cyclization of 2-diazoniodiaryl ketones II (same R, R1, X-X2) under direct, (bpy)3Ru(II)- (bpy = 2,2′-bipyridine), or (bpy)3Ru(II)-Cu(II)-photosensitized conditions. Where selectivities were possible in the ring closure, the isomer ratios obtained were in accord with an intermediate aryl radical.
As far as I know, this compound(455-70-9)Safety of Methyl 5-fluoro-3-pyridinecarboxylate can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem