Product Details of 707-61-9. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 4-Methyl-1-phenyl-2,3-dihydro-1H-phosphole 1-oxide, is researched, Molecular C11H13OP, CAS is 707-61-9, about Preparation and characterization of novel 4-bromo-3,4-dimethyl-1-phenyl-2-phospholene 1-oxide and the analogous phosphorus heterocycles or phospha sugars. Author is Yamada, Manabu; Yamashita, Mitsuji; Suyama, Takuya; Yamashita, Junko; Asai, Kazuhide; Niimi, Taishi; Ozaki, Nobuhisa; Fujie, Michio; Maddali, Kasthuraiah; Nakamura, Satoki; Ohnishi, Kazunori.
4-Bromo-3,4-dimethyl-1-phenyl-2-phospholene 1-oxide (3c) was 1st synthesized from 3,4-dimethyl-1-phenyl-2-phospholene 1-oxide (2c) by a bromo-radical substitution reaction occurred at C-4 position by N-bromosuccinimide and 2,2′-azobisisobutyronitrile. The novel phospha sugar analog 3c exerted high anti-proliferative effect on U937 cells evaluated by MTT in vitro methods and was much more efficient than that of Gleevec, which is known as a mol. targeting chemotherapeutical agent. The substitution of 2-phospholenes at C-3 and C-4 position with Me groups as well as 4-bromo substituent suggests a good anti-proliferative effect.
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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem