Application In Synthesis of H-Trp-OMe.HCl. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: H-Trp-OMe.HCl, is researched, Molecular C12H15ClN2O2, CAS is 7524-52-9, about Examination of sulfonamide-based inhibitors of MMP3 using the conditioned media of invasive glioma cells. Author is Poole, Alisha T.; Sitko, Christopher A.; Le, Caitlin; Naus, Christian C.; Hill, Bryan M.; Bushnell, Eric A. C.; Chen, Vincent C..
Glioblastoma multiforme (GBM) is the deadliest and the most common primary malignant brain tumor. The median survival for patients with GBM is around one year due to the nature of glioma cells to diffusely invade that make the complete surgical resection of tumors difficult. Based upon the connexin43 (Cx43) model of glioma migration we have developed a computational framework to evaluate MMP inhibition in materials relevant to GBM. Using the ilomastat Leu-Trp backbone, we have synthesized novel sulfonamides and monitored the performance of these compounds in conditioned media expressing MMP3. From the results discussed herein we demonstrate the performance of sulfonamide based MMPIs included AP-3, AP-6, and AP-7.
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Reference:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem