The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic, and theoretical assessments of solvent structures and their interactions with reaction intermediates and transition states. 57-50-1, Name is Sucrose, SMILES is O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@H]1O[C@@]2(CO)[C@H]([C@@H]([C@@H](CO)O2)O)O, in an article , author is Wu, CD, once mentioned of 57-50-1, SDS of cas: 57-50-1.
We report here that N-2-aryl-3-(isoxazolylsulfamoyl)-2-thiophenecarboxamides are potent and selective small molecule ETA receptor antagonists. The aryl group was subjected to extensive structural modification. With monosubstitution, the para position was most useful in increasing potency, with methyl being preferred. With disubstitution, 2,4-disubstitution further enhanced activity with methyl or cyano groups being preferred at the 2-position. In this series, a benzo-[d][1,3]dioxole group is equivalent to a 4-methyl group in in vitro activity and afforded the compounds with both in vivo activity and moderate half-lives.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 57-50-1. COA of Formula: https://www.ambeed.com/products/57-50-1.html.
Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem