New research progress on 54623-25-5 in 2021. Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. In an article, author is Kokosza, Kamil, once mentioned the application of 54623-25-5, Name: 2,3,5-Tri-O-benzyl-D-ribose, Name is 2,3,5-Tri-O-benzyl-D-ribose, molecular formula is C26H28O5, molecular weight is 420.4975, MDL number is MFCD03425640, category is dioxole. Now introduce a scientific discovery about this category.
NOVEL 5-ARYLCARBAMOYL-2-METHYLISOXAZOLIDIN-3-YL-3-PHOSPHONATES AS NUCLEOTIDE ANALOGUES
A series of 5-substituted 3-phosphonylated isoxazolidines have been obtained via cycloaddition of N-methyl-C-(diethoxyphosphoryl)nitrone with N-heteroaromatic acrylamides. Good trans/cis diastereoselectivities (d.e. 58-76%) of isomeric (3-diethoxyphosphoryl)isoxazolidines were observed. cis- and trans-Isoxazolidine phosphonates were evaluated for their antiviral activity against a broad range of DNA and RNA viruses but were found inactive. Their cytostatic activity toward L1210, CEM, and HeLa cells was also established, and compounds cis-12r and trans-11r having a 2,2-difluorobenzo[d][1,3]dioxole moiety slightly inhibited proliferation of HeLa cells at IC50 values of 186 and 179 mu M, respectively.
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Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem