Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 122111-11-9, Name is ((2R,3R)-3-(Benzoyloxy)-4,4-difluoro-5-((methylsulfonyl)oxy)tetrahydrofuran-2-yl)methyl benzoate, SMILES is O=C(OC[C@H]1OC(OS(=O)(C)=O)C(F)(F)[C@@H]1OC(C2=CC=CC=C2)=O)C3=CC=CC=C3, belongs to dioxoles compound. In a document, author is Wu, Liqiang, introduce the new discover, Product Details of 122111-11-9.
Synthesis and anti-proliferative activity evaluation of novel benzo[d] [1,3] dioxoles-fused 1,4-thiazepines
Benzo[d][1,3]dioxoles 1,4-thiazepines remarkable antitumor activities, benzo[d][1,3]dioxoles-fused 1,4thiazepines, which combine two biologically active heterocyclic cores, are expected to be of pharmacological interest, We therefore envisaged that integrating 1,4-thiazepine and benzo[d][1,3]dioxole moieties in one molecular platform could potentially produce novel compounds with significant synergistic antitumor properties. A series of novel benzo[d][1,3]dioxoles-fused 1,4-thiazepines, designed via molecular hybridization approach, were synthesized in very good yields using one-pot condensation of 3,4-methylenedioxyaniline, aldehydes, and alpha-mercaptocarboxylic acids under solvent-free condition. The anti-proliferative activities of all the synthesized compounds were assessed on two different human cancer cell lines (Esophageal squamous cell carcinoma Ec9706 and Eca109), and the results showed that compound 4e showed the best anti-tumor activity with IC50 values of 8.23 mu M and 16.22 mu M against Ec9706 and Eca109 cell lines, respectively, which was 2-3 times more potent than 5-Fluorouracil (IC50 = 23.26 mu M and 30.25 mu M against Ec9706 and Eca109 respectively). These novel benzo[d][1,3] dioxoles fused with bioactive heterocyclic skeletons may find their pharmaceutical applications after further investigations. (C) 2017 Elsevier Masson SAS. All rights reserved.
The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 122111-11-9 is helpful to your research. Product Details of 122111-11-9.
Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem