37830-90-3, 4,5-Dimethyl-1,3-dioxol-2-one is a Dioxole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Add 50.0 g of 4,5-dimethyl-1,3-dioxol-2-one to a 1 L four-necked flask.530 g of dichloromethane, stirred and dissolved, and heated to reflux, when the internal temperature is not lower than 40 ¡ã C,A mixture of 65 g (1.1 equivalents) of sulfonyl chloride and 132 g of dichloromethane was added dropwise.The internal temperature of the control is not lower than 40 ¡ãC, and the mixture is kept warm for 2 hours after the dropwise addition.The temperature was then raised to 85 ¡ã C while distilling off the dichloromethane. When it reaches 85 ¡ã C, it is rearranged for 2 to 3 hours.At room temperature, crude DMDO-Cl was obtained with a GC purity of 85percent to 90percent.Add 30 ml of isopropanol to the above crude product, stir and cool to -10 ¡ã C ~ -5 ¡ã C,Crystallization 0 ~ 1h, suction filtration, rinse with isopropanol down to -5 ¡ã C,Obtained white crystals 53.3g (yield 81.9percent, GC purity 99.3percent)
37830-90-3 4,5-Dimethyl-1,3-dioxol-2-one 142210, aDioxole compound, is more and more widely used in various.
Reference£º
Patent; Zhejiang Huahai Pharmaceutical Co., Ltd.; Wang Jiquan; Li Guoxiang; Xiong Xueqiang; (6 pag.)CN103864748; (2019); B;,
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