Academic researchers, R&D teams, teachers, students, policy makers and the media all rely on us to share knowledge that is reliable, accurate and cutting-edge. 526-95-4, Name is Gluconic Acid (contains Gluconolactone), SMILES is O[C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)C(O)=O, in an article , author is Xu, Zhou, once mentioned of 526-95-4, Recommanded Product: 526-95-4.
An epoxidized safrole, 5-(oxiran-2-ylmethyl)-benzo[d][1,3] dioxole (OYBD), was synthesized and employed to modify collagen for improving its antibacterial activity. The interaction between collagen and OYBD, and the structure/properties of the modified collagen were investigated in detail. The results indicated that the OYBD-modified collagen showed a higher de-nature temperature (Td, 90.2 degrees C), improved hydrophobic properties (contact angle from 84.2 degrees to 89.1 degrees) and enhanced tensile strength (6.2-11.0%) without destroying its triple helix structure. From observation of scanning electron microscopy (SEM), a higher density of intertwining morphology and a more stable network structure were observed, which was consistent with improved tensile strength and reduced breaking extension stress. The antibacterial test and LIVE/DEAD Baclight bacterial viability assay illustrated that the modified collagen exhibited excellent antibacterial activity to both Gram-negative and Gram-positive bacteria. Furthermore, the OYBD-modified collagen still exhibited cytocompatibility, supporting human fibroblast proliferation, which holds a great potential for developing antibacterial collagen-based biomaterials.
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Reference:
1,3-Benzodioxole – Wikipedia,
,Dioxole | C3H4O2 – PubChem