Chemical composition and biological activity of the volatile oils of Hyptis spicigera against Trypanosoma brucei brucei, (Tbb) found in Northern Nigeria was written by Ladan, Z.;Amupitan, J. O.;Oyewale, O. A.;Okonkwo, E. M.;Ladan, E. O.;Odjobo, B.;Habila, N.. And the article was included in African Journal of Pure and Applied Chemistry in 2011.COA of Formula: C8H14O2 This article mentions the following:
The hydrodistillation of the fresh leaves of Hyptis spicigera gave a colorless volatile oil with yield of 0.65%. The volatile oil gave forty compounds on the basis of gas chromatog.-mass spectroscopy (GC-MS) with low composition of cineole (4.11%) and caryophyllene (2.61%) while α-pinene (12.16%) β-pinene (9.47%) and α-phellandrene (10.19%) were predominant compounds The biol. activity of the volatile oils was evaluated in vitro for activity against Trypanosoma brucei brucei (Tbb) and was found to possess anti-trypanosoma activity in vitro in a dose dependent pattern at 0.5 μg/mL in 6 min. This activity showed the volatile oils from H. spicigera leaves to be a potential trypanocide. In the experiment, the researchers used many compounds, for example, 1,4-Dioxaspiro[4.5]decane (cas: 177-10-6COA of Formula: C8H14O2).
1,4-Dioxaspiro[4.5]decane (cas: 177-10-6) belongs to dioxole derivatives. Dioxoles, particularly fluorinated dioxoles, are used as co-monomers to make polymers that find use in forming protective coatings for chemical resistance. Dioxole functionalized metal-organic frameworks have also been recently reported.COA of Formula: C8H14O2
Referemce:
1,3-Benzodioxole – Wikipedia,
Dioxole | C3H4O2 – PubChem